Transition Metals in the Synthesis of Complex Organic Molecules


Author: Louis S. Hegedus
Publisher: University Science Books
ISBN: 9781891389047
Category: Science
Page: 337
View: 8845

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This second edition offers easy access to the field of organotransition metal chemistry. The book covers the basics of transition metal chemistry, giving a practical introduction to organotransition reaction mechanisms.

Transition Metals in the Synthesis of Complex Organic Molecules


Author: Louis S. Hegedus,Bjorn Soderberg
Publisher: Univ Science Books
ISBN: N.A
Category: Science
Page: 459
View: 9747

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This texts offers a clear and systematic approach to the formation, manipulation, and reactivity of organometallic complexes. It presents the organic chemistry of transition metals by class of metal complex, with many examples of applications in the synthesis of complex natural products and pharmaceuticals.

Advances in Transition-Metal Mediated Heterocyclic Synthesis


Author: Daniel Sole,Israel Fernandez
Publisher: Academic Press
ISBN: 0128116528
Category: Science
Page: 366
View: 4367

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Advances in Transition-Metal Mediated Heterocyclic Synthesis provides an overview of recent catalytic reactions involving transition metals to produce heterocyclic compounds. The book is organized according to the type of transformation used to achieve the synthesis of the heterocyclic systems (mainly aza- and oxa-heterocycles). As such, it covers recent applications on the synthesis of heterocycles, also describing the details of the novel transformations in a didactic manner to motivate readers in search of new catalytic processes. The editors have included state-of-the-art strategies, including transition-metal reactions involving unsaturated systems (reactions of allenes, new gold(I)-catalyzed reactions, and Prins reaction). Chapters highlight the versatility of organopalladium chemistry dealing with carbonylative transformations, C-H activation reactions, coupling processes, and the control of the ambiphilic character of organopalladium species. Finally, the book discusses new reactions leading to heterocycles based on C-H activation processes catalyzed by other metals (Rh, Ru, Co). Written by an outstanding team of authors who are leading experts in organometallic chemistry and organic synthesis, this book is a valuable resource not only for chemists mainly focused on synthesis, but also for those interested in reaction mechanisms involving transition metals. Helpfully organized by transformation type to stimulate the search for new synthetic processes Completely illustrated and written by global experts Includes thoughtfully selected strategies chosen by the editors to exemplify the state-of-the-art of the subject, including transition-metal reactions involving unsaturated systems, organopalladium chemistry, and metal-catalyzed C-H activation

Organic synthesis workbook


Author: Jan-Arne Gewert
Publisher: Wiley-VCH Verlag GmbH
ISBN: 9783527301874
Category: Science
Page: 274
View: 7463

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From the Foreword written by Erick M. Carreira: "... The Organic Synthesis Workbook is an ideal compilation of state-of-the art modern syntheses which wonderfully showcases the latest advances in synthetic chemistry in combination with fundamentals in a question-and-answer format. The structure of the book is such that the reader can appreciate the intricacies of strategic planning, reagent tailoring, and structural analysis within the context of the individual synthetic targets. In providing highlights of synthesis from a wider range of natural products classes (alkaloids, terpenes, macrolides) the reader is given a tour through a broad range of reaction chemistry and concepts. Moreover, because in its scope the authors have ignored international borders, the book effectively parlays the global aspect of current research in the exciting field of organic synthesis... The Organic Synthesis Workbook promises to be to the current generation of graduate students, and even "students-for-life", what Ireland's and Alonso's books were to those of us who were graduate students in the 80's [Alsono: The Art of Problem Solving in Organic Chemistry, Ireland: Organic Synthesis]. The authors have wonderfully captured the thrill, the enjoyment, and the intellectual rigor that is so characteristic of modern synthetic organic chemistry."

High-Resolution NMR Techniques in Organic Chemistry


Author: Timothy D.W. Claridge
Publisher: Elsevier
ISBN: 008099993X
Category: Science
Page: 552
View: 2145

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High-Resolution NMR Techniques in Organic Chemistry, Third Edition describes the most important NMR spectroscopy techniques for the structure elucidation of organic molecules and the investigation of their behaviour in solution. Appropriate for advanced undergraduate and graduate students, research chemists and NMR facility managers, this thorough revision covers practical aspects of NMR techniques and instrumentation, data collection, and spectrum interpretation. It describes all major classes of one- and two-dimensional NMR experiments including homonuclear and heteronuclear correlations, the nuclear Overhauser effect, diffusion measurements, and techniques for studying protein–ligand interactions. A trusted authority on this critical expertise, High-Resolution NMR Techniques in Organic Chemistry, Third Edition is an essential resource for every chemist and NMR spectroscopist.

Recent Advances in Hydride Chemistry


Author: Maurizio Peruzzini,Rinaldo Poli
Publisher: Elsevier
ISBN: 9780080540337
Category: Science
Page: 578
View: 3583

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This book has been conceived to collect the most important recent advances in all areas of hydride chemistry research, including chemical reactivity, instrumental investigation, theory, and applications in the areas of catalysis, biochemistry and materials science. Many of the chapters have been written by the plenary lecturers of the EURO-Hydrides 2000 conference, but other leading scientists in this field have also been invited to contribute. The first part of the book focuses on the chemistry and catalysis of transition metal hydrides. Another block of chapters illustrates the most recent advances in the application of instrumental techniques to the study of the properties and reactivity of hydride compounds. The final part of the book illustrates the relevance of metal-hydrogen bonds in biochemistry and materials science. All of the chapters of this book have been evaluated by independent reviewers.

Direct Synthesis of Metal Complexes


Author: B.I. Kharisov
Publisher: Elsevier
ISBN: 0128110627
Category: Science
Page: 468
View: 6568

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Direct Synthesis of Metal Complexes provides in-depth coverage of the direct synthesis of coordination and organometallic compounds. The work is primarily organized by methods, but also covers highly relevant complexes, such as metal-polymer coordination compounds. This updated reference discusses recent developments in cryosynthesis, electrosynthesis, and tribosynthesis (popular as it doesn’t require organic solvents), with special attention paid to ‘greener’ methodologies and approaches. Additionally, the book describes physical methods of zero-valent metal interaction with organic matter, including sputtering, ultrasonic treatment and synthesis in ionic liquids. The book presents completely new content as a follow-up to the 1999 Elsevier Science publication Direct Synthesis of Coordination and Organometallic Compounds that was edited by Dr. Garnovskii and Dr. Kharisov. Covers current methods and techniques of metal interactions with organic media leading to metal chelates, adducts, di- and polymetallic complexes, metal-containing macrocycles, supported coordination compounds (i.e., metal complexes on carbon nanotubes), and more Describes reactivities of distinct forms of elemental metals (powders, sheets, nanoparticles (including a host of less-common metal nanostructures) with organic phase (liquid, solid and gaseous) and water Includes experimental procedures, with examples of direct synthesis, at the end of each chapter

Molecular Biology of the Cell


Author: Bruce Alberts
Publisher: Garland Science
ISBN: 1317563743
Category: Science
Page: 1464
View: 3012

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As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.

Transition Metals in Total Synthesis


Author: Peter J. Harrington
Publisher: Wiley-Interscience
ISBN: N.A
Category: Science
Page: 484
View: 9118

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Examines the use of transition metal complexes as reagents for the synthesis of complex organic molecules. Presented here are total syntheses whose efficiency depends upon the unique reactivity patterns of organometallic complexes. For each total synthesis, the biological activity of the molecule is presented, followed by discussion of the principles of the organometallic processes involved.

Transition Metal Arene P-Complexes in Organic Synthesis and Catalysis


Author: E.P. Kündig,A. Böttcher
Publisher: Springer Science & Business Media
ISBN: 9783540016045
Category: Science
Page: 232
View: 861

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Metal-arene p-complexes show a rich and varied chemistry. The metal adds a third dimension to the planar aromatic compounds and coordination of a metal to an arene thus not only altering the reactivity of ring-carbons and substituents but also makes possible reactions that lead to chiral non-racemic products. This book, organized in nine chapters and written by leading scientists in the field provides the reader with an up-to-date treatise on the subject organized according to reaction type and use. It covers the wide spectrum of arene activation: from the electrophilic activation of h6-bound areneï⿬ by p-Lewis acid metal complex fragments, to reactions of nucleophilic h2-coordinated arene complexes. The preparation of complexes is detailed, as are the scope, limitations and challenges of reactions in contemporary p-arene metal chemistry with special attention given to asymmetric transformations. The emphasis of the book is on transformations of interest to organic synthesis and on the use of the complexes as catalysts or as chiral ligands. The book is written for academic and industrial researchers in organic, organometallic, and inorganic chemistry as well as for advanced chemistry students

Transition-Metal-Mediated Aromatic Ring Construction


Author: Ken Tanaka
Publisher: John Wiley & Sons
ISBN: 111862999X
Category: Science
Page: 830
View: 5519

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State-of-the-science methods, synthetic routes, and strategies to construct aromatic rings The development of new reactions for the synthesis of aromatic compounds is a highly active research area in organic synthesis, providing new functional organic materials, functional reagents, and biologically active compounds. Recently, significant advances in transition-metal-mediated reactions have enabled the efficient and practical construction of new aromatic rings with useful properties and applications. This book draws together and reviews all the latest discoveries and methods in transition-metal-mediated reactions, offering readers promising new routes to design and construct complex aromatic compounds. Integrating metal catalysis with aromatic compound synthesis, Transition-Metal-Mediated Aromatic Ring Construction offers a practical guide to the methods, synthetic routes, and strategies for constructing aromatic compounds. The book's five parts examine: [2+2+2], [2+2+1], and related cycloaddition reactions [4+2], [3+2], and related cycloaddition reactions Electrocyclization reactions Coupling and addition reactions Other important transformations, including methathesis reactions and skeletal rearrangement reactions Edited by Ken Tanaka, an internationally recognized expert in the field of transition-metal catalysis, the book features authors who are leading pioneers and researchers in synthetic reactions. Their contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience developing new aromatic compounds. All chapters end with a summary and outlook, setting forth new avenues of research and forecasting new discoveries. There are also references at the end of each chapter, guiding readers to important original research reports and reviews. In summary, Transition-Metal-Mediated Aromatic Ring Construction offers synthetic chemists a promising new avenue for the development of important new aromatic compounds with a broad range of applications.

Applications of Transition Metal Catalysis in Drug Discovery and Development

An Industrial Perspective
Author: Matthew L. Crawley,Barry M. Trost
Publisher: John Wiley & Sons
ISBN: 1118309839
Category: Science
Page: 384
View: 1213

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This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.

Introduction to Strategies for Organic Synthesis


Author: Laurie S. Starkey
Publisher: John Wiley & Sons
ISBN: 1119347238
Category: Science
Page: 432
View: 7007

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Bridging the Gap Between Organic Chemistry Fundamentals and Advanced Synthesis Problems Introduction to Strategies of Organic Synthesis bridges the knowledge gap between sophomore-level organic chemistry and senior-level or graduate-level synthesis to help students more easily adjust to a synthetic chemistry mindset. Beginning with a thorough review of reagents, functional groups, and their reactions, this book prepares students to progress into advanced synthetic strategies. Major reactions are presented from a mechanistic perspective and then again from a synthetic chemist’s point of view to help students shift their thought patterns and teach them how to imagine the series of reactions needed to reach a desired target molecule. Success in organic synthesis requires not only familiarity with common reagents and functional group interconversions, but also a deep understanding of functional group behavior and reactivity. This book provides clear explanations of such reactivities and explicitly teaches students how to make logical disconnections of a target molecule. This new Second Edition of Introduction to Strategies for Organic Synthesis: Reviews fundamental organic chemistry concepts including functional group transformations, reagents, stereochemistry, and mechanisms Explores advanced topics including protective groups, synthetic equivalents, and transition-metal mediated coupling reactions Helps students envision forward reactions and backwards disconnections as a matter of routine Gives students confidence in performing retrosynthetic analyses of target molecules Includes fully-worked examples, literature-based problems, and over 450 chapter problems with detailed solutions Provides clear explanations in easy-to-follow, student-friendly language Focuses on the strategies of organic synthesis rather than a catalogue of reactions and modern reagents The prospect of organic synthesis can be daunting at the outset, but this book serves as a useful stepping stone to refresh existing knowledge of organic chemistry while introducing the general strategies of synthesis. Useful as both a textbook and a bench reference, this text provides value to graduate and advanced undergraduate students alike.

Transition Metal Reagents and Catalysts

Innovations in Organic Synthesis
Author: Jiro Tsuji
Publisher: John Wiley & Sons
ISBN: 9780471560272
Category: Science
Page: 477
View: 8766

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Transition Metal Reagents and Catalysts Innovations in OrganicSynthesis Jiro Tsuji Emeritus Professor, Tokyo Institute ofTechnology, Japan Numerous innovative and practical syntheticmethods using transition metal complexes as either catalysts orreagents have been developed over the last 35 years. TransitionMetal Reagents and Catalysts combines the varied applications oftransition metal complexes in a unique and timely book in thisrapidly advancing area of organic synthesis. This text is an easilyunderstandable and enjoyable read for organic chemists who are notyet familiar with organo-transition metal chemistry. TransitionMetal Reagents and Catalysts presents: * Complete coverage of nearly 35 years of transition metal complexchemistry * An in-depth treatment of many innovative syntheticmethodologies * A rational classification of all reactions according tosubstrates and reaction mechanisms * Examples of important applications of transition metal catalysedreactions. A knowledge of organic synthesis using transition metal complexesis a must for all synthetic organic chemists. Written for chemistswho wish to apply novel synthetic methods using transition metalcomplexes to solve problems in organic and pharmaceuticalchemistry, such as synthesis of fine and bulk chemicals and naturalproducts, Transition Metal Reagents and Catalysts is an essentialreference source and an indispensible research companion.

Encyclopedia of Interfacial Chemistry

Surface Science and Electrochemistry
Author: N.A
Publisher: Elsevier
ISBN: 0128098945
Category: Science
Page: 5560
View: 6458

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Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry summarizes current, fundamental knowledge of interfacial chemistry, bringing readers the latest developments. As the chemical and physical properties and processes at solid and liquid interfaces are the scientific basis of so many technologies which enhance our lives and create new opportunities, its important to highlight how these technologies enable the design and optimization of functional materials for heterogeneous and electro-catalysts in food production, pollution control, energy conversion and storage, medical applications requiring biocompatibility, drug delivery, and more. This book provides an interdisciplinary view that lies at the intersection of these three related fields. Presents fundamental knowledge of interfacial chemistry, surface science and electrochemistry and provides cutting-edge research from academics and practitioners across various fields and global regions

Chemistry of Tantalum and Niobium Fluoride Compounds


Author: Anatoly Agulyansky
Publisher: Elsevier
ISBN: 9780080529028
Category: Science
Page: 408
View: 6947

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Electronic, optical, mechanical and medical appliances are just a few examples of modern applications that use tantalum and niobium. In Chemistry of Tantalum and Niobium Fluoride Compounds, the author draws on thirty years' experience to produce the first ever monograph to systemize and summarize the data available on tantalum and niobium fluoride compounds. This comprehensive reference source offers a rich variety of study methodology and is invaluable to researchers examining the chemistry of fluorides, as well as teachers and students in chemistry and metallurgy. * Collects the latest research on the chemistry of complex fluorides and oxyfluorides of Tantalum and Niobium. * Covers both theory and application of Tantalum and Niobium Fluoride Chemistry * Is suitable for tantalum and niobium producers, researchers studying the chemistry of fluorides, as well as teachers and students in chemistry and metallurgy

Stereochemistry of Coordination Compounds


Author: Alexander von Zelewsky
Publisher: John Wiley & Sons
ISBN: 9780471955993
Category: Science
Page: 266
View: 2194

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This well-illustrated and well-referenced book provides a systematic introduction to the modern aspects of the topographical stereochemistry of coordination compounds, which are made up of metal ions surrounded by other non-metal atoms, ions and molecules.