The Networking of Chaperones by Co-chaperones

Control of Cellular Protein Homeostasis
Author: Gregory Lloyd Blatch,Adrienne Lesley Edkins
Publisher: Springer
ISBN: 3319117319
Category: Medical
Page: 276
View: 3455

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Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets. The book will be a resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.

Regulation of Heat Shock Protein Responses


Author: Alexzander A A Asea,Punit Kaur
Publisher: Springer
ISBN: 3319747150
Category: Medical
Page: 472
View: 5325

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This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I - HSP and Stress Responses; Section II - Chaperone Functions of HSP; Section III - HSP in Human Diseases; Section IV - Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.

The Hsp70 Molecular Chaperone Machines


Author: Matthias P. Mayer,Pierre Goloubinoff
Publisher: Frontiers Media SA
ISBN: 2889451259
Category:
Page: N.A
View: 4699

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Members of the HSP70 family form a central hub of the molecular chaperone network, controlling protein homeostasis in prokaryotes and in the ATP-containing compartments of the eukaryotic cells. The heat-inducible form HSPA1A (HSP70), its constitutive cytosolic cognate HSPA8 (Hsc70), its endoplasmic reticulum form HSPA5 (BiP), and its mitochondrial form HSPA9 (Mortalin), as well as the more distantly related HSPHs (HSP110s), make up 1-2 % of the total mass of proteins in human cells. They use the energy of ATP-hydrolysis to prevent and forcefully revert the process of protein misfolding and aggregation during and following various stresses, presumably by working as unfoldases to lift aberrant conformers out of kinetic traps. As such, HSP70s, in cooperation with their J-domain co-chaperones and nucleotide exchange factors (NEFs) and co-disaggregases, form an efficient network of cellular defenses against the accumulation of cytotoxic misfolded protein conformers, which may cause degenerative diseases such as Parkinson's and Alzheimer's disease, diabetes, and aging in general. In addition to their function in repair of stress-induced damage, HSP70s fulfill many housekeeping functions, including assisting the de novo folding and maturation of proteins, driving the translocation of protein precursors across narrow membrane pores into organelles, and by controlling the oligomeric state of key regulator protein complexes involved in signal transduction and vesicular trafficking. For reasons not well understood, HSP70s are also found on the surface of some animal cells, in particular cancer cells where they may serve as specific targets for cancer immunotherapy. Here, we gathered seven mini reviews, each presenting a complementary aspect of HSP70’s structure and function in bacteria and eukaryotes, under physiological and stressful conditions. These articles highlight how, the various members of this conserved family of molecular chaperones, assisted by their various J-domain and NEF cochaperones and co-disaggregases, harness ATP hydrolysis to perform a great diversity of life-sustaining cellular functions using a similar molecular mechanism.

The Molecular Chaperones Interaction Networks in Protein Folding and Degradation


Author: Walid A. Houry
Publisher: Springer
ISBN: 1493911309
Category: Science
Page: 485
View: 5995

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Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime. Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions. Chaperones can also assist in the unfolding and degradation of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion. In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones. In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks. Finally, there is now a growing interest in the role of molecular chaperones in diseases. This book will provide a comprehensive analysis of the structure and function of the diverse systems of molecular chaperones and their role in cell stress responses and in diseases from a global network perspective. ​

Lehrbuch der Biochemie


Author: Donald Voet,Judith G. Voet,Annette Beck-Sickinger,Charlotte W. Pratt
Publisher: VCH
ISBN: 9783527326679
Category: Biochemistry
Page: 1253
View: 1225

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Ein echter Voet: Leicht verständliche chemische Grundlagen, brillante Strukturbilder und eine durchgehende Erklärung biochemischer Phänomene aus den zu Grunde liegenden molekularen Mechanismen - das sind die Markenzeichen des "Voet". Wer mit diesem Buch lernt, erfährt nicht nur das "Was?", sondern immer auch das "Warum?". Zahlreiche Exkurse in die Molekularbiologie, die Biomedizin und in andere verwandte Wissenschaften stellen fachübergreifende Bezüge her und führen gleichzeitig in aktuelle Fragestellungen aus der biochemischen Forschung ein. Neu in der zweiten Auflage: Ein zusätzliches Kapitel über biologische Signaltransduktion. Hier werden die wichtigsten Signalwege besprochen: Hormonelle Steuerung, Tyrosinkinasen, G-Proteine, und der Phosphoinositolweg. Über 100 neue hochaufgelöste Protein- und Nucleinsäurestrukturen samt den daraus abgeleiteten Erkenntnissen zu molekularen Mechanismen. Viele neue Molekularstrukturen, u. a. Chaperoninkomplexe, SNARE-Komplex, spannungsabhängige Ionenkanäle, ABC-Transporter, G-Proteine, Cytochrom c-Oxidase, ATP Synthase, Pyruvatdehydrogenasekomplex, RNA Polymerase II, RNAse P, kleine und große ribosomale Untereinheit. Neue Exkurse stellen 21 berühmte Biochemiker und ihre bahnbrechenden Entdeckungen vor, darunter Linus Pauling, Otto Warburg, Hans Krebs, Max Perutz, Arthur Kornberg. Aktuelle Forschungsschwerpunkte mit direktem Bezug zur Biochemie werden vorgestellt; u. a. Genomsequenzierung, Systembiologie, Metabolomik, Proteindatenbanken, Epigenetik, Biofi lme, Prionenkrankheiten, RNA-Interferenz, pharmazeutische Wirkstoffentwicklung, Vesikeltransport, Apoptose, "Riboswitches". 450 Übungsaufgaben mit Lösungen im Anhang stehen zur Lernkontrolle zur Verfügung, darunter mehr als 150 neue. Die Multimedia-Unterstützung ist jetzt mit rund 250 Animationen und interaktiven Übungen noch umfangreicher und über das Internet jederzeit frei zugänglich. Stimmen zur ersten Auflage: "Der Titel der Originalausgabe ... Fundamentals of Biochemistry ist verräterisch. Es ist ein Grundlagenlehrbuch, das sich primär an Studenten aller Fachrichtungen richtet, die einführende Vorlesungen der Biochemie hören. Das Schwergewicht liegt hier weniger auf enzyklopädischer Detailfülle als auf Prinzipien und deren Verständnis. Der Voet/Voet/Pratt ist "Didaktik pur"! Chemie in unserer Zeit "Das Buch ist sehr ausführlich, aber trotzdem gut strukturiert geschrieben... Zudem fließen oft aktuelle Forschungsbereiche ein, so dass es sehr angenehm ist mit dem Lehrbuch der Biochemie zu arbeiten und zu lernen." uni-online

Issues in Biomedical Engineering Research and Application: 2011 Edition


Author: N.A
Publisher: ScholarlyEditions
ISBN: 1464964556
Category: Technology & Engineering
Page: 1451
View: 7230

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Issues in Biomedical Engineering Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biomedical Engineering Research and Application. The editors have built Issues in Biomedical Engineering Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biomedical Engineering Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biomedical Engineering Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in Life Sciences: Molecular Biology: 2011 Edition


Author: N.A
Publisher: ScholarlyEditions
ISBN: 1464963495
Category: Science
Page: 3330
View: 4595

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Issues in Life Sciences: Molecular Biology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Life Sciences—Molecular Biology. The editors have built Issues in Life Sciences: Molecular Biology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Life Sciences—Molecular Biology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences: Molecular Biology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in Biological and Life Sciences Research: 2011 Edition


Author: N.A
Publisher: ScholarlyEditions
ISBN: 1464963355
Category: Science
Page: 5106
View: 6710

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Issues in Biological and Life Sciences Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biological and Life Sciences Research. The editors have built Issues in Biological and Life Sciences Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biological and Life Sciences Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biological and Life Sciences Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Cancer: New Insights for the Healthcare Professional: 2011 Edition


Author: N.A
Publisher: ScholarlyEditions
ISBN: 1464900027
Category: Medical
Page: 3937
View: 622

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Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Stoffwechselphysiologie der Pflanzen

Physiologie und Biochemie des Primär- und Sekundärstoffwechsels ; 10 Tabellen
Author: Gerhard Richter
Publisher: Georg Thieme Verlag
ISBN: 9783134420067
Category: Plants
Page: 583
View: 9691

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Issues in Life Sciences: Botany and Plant Biology Research: 2011 Edition


Author: N.A
Publisher: ScholarlyEditions
ISBN: 1464963436
Category: Science
Page: 3674
View: 6448

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Issues in Life Sciences: Botany and Plant Biology Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Life Sciences—Botany and Plant Biology Research. The editors have built Issues in Life Sciences: Botany and Plant Biology Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Life Sciences—Botany and Plant Biology Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences: Botany and Plant Biology Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition


Author: N.A
Publisher: ScholarlyEditions
ISBN: 1464963444
Category: Medical
Page: 4229
View: 9052

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Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Molekulare Zellbiologie


Author: Arnold Berk,David Baltimore,Harvey Lodish,James Darnell,Paul Matsudaira,S. Lawrence Zipursky
Publisher: Walter de Gruyter
ISBN: 3110810573
Category: Science
Page: 1491
View: 7767

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Molekularbiologie der Zelle


Author: Bruce Alberts,Alexander Johnson,Julian Lewis,Martin Raff,Keith Roberts,Peter Walter
Publisher: John Wiley & Sons
ISBN: 3527323848
Category: Cells
Page: 1928
View: 5720

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Seit einem Vierteljahrhundert ist 'Molekularbiologie der Zelle' das führende Lehrbuch im Bereich Zellbiologie. Diese erfolgreiche Tradition wird nun mit der fünften Auflage fortgesetzt, die vollständig überarbeitet und aktualisiert wurde. Mit zahlreichen inhaltlichen Neuerungen stellt sie unser aktuelles, sich rasch weiterentwickelndes Wissens zum zentralen Gegenstand der Biologie dar - der Zelle.

Vitamine und Spurenelemente

Bedarf, Mangel, Hypervitaminosen und Nahrungsergänzung
Author: Hartmut Dunkelberg,Thomas Gebel,Andrea Hartwig
Publisher: John Wiley & Sons
ISBN: 3527653074
Category: Technology & Engineering
Page: 400
View: 9461

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Expertenwissen für jedermann: Diese Auskopplung aus dem "Handbuch der Lebensmitteltoxikologie" beschreibt umfassend und kompetent die für die Ernährung wichtigsten Vitamine und Spurenelemente.

Jäger

Roman
Author: Greg Bear
Publisher: N.A
ISBN: 9783453521940
Category:
Page: 445
View: 6731

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