The Making of a Fly

The Genetics of Animal Design
Author: P. A. Lawrence
Publisher: Wiley-Blackwell
ISBN: 9780632030484
Category: Science
Page: 240
View: 7359

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Understanding how a multicellular animal develops from a single cell (the fertilized egg) poses one of the greatest challenges in biology today. Development from egg to adult involves the sequential expression of virtually the whole of an organism's genetic instructions both in the mother as she lays down developmental cues in the egg, and in the embryo itself. Most of our present information on the role of genes in development comes from the invertebrate fruit fly, Drosophila. The two authors of this text (amongst the foremost authorities in the world) follow the developmental process from fertilization through the primitive structural development of the body plan of the fly after cleavage into the differentiation of the variety of tissues, organs and body parts that together define the fly. The developmental processes are fully explained throughout the text in the modern language of molecular biology and genetics. This text represents the vital synthesis of the subject that many have been waiting for and it will enable many specific courses in developmental biology and molecular genetics to focus on it. It will appeali to 2nd and 3rd year students in these disciplines as well as in biochemistry, neurobiology and zoology. It will also have widespread appeal among researchers. Authored by one of the foremost authorities in the world. A unique synthesis of the developmental cycle of Drosophila - our major source of information on the role of genes in development. Designed to provide the basis of new courses in developmental biology and molecular genetics at senior undergraduate level. A lucid explanation in the modern language of the science.

The Evolutionary Biology of Flies


Author: David K. Yeates,Brian M. Wiegmann
Publisher: Columbia University Press
ISBN: 0231127006
Category: Science
Page: 430
View: 7356

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Classical Japanese: A Grammar is a comprehensive, and practical guide to classical Japanese. Extensive notes and historical explanations make this volume useful as both a reference for advanced students and a textbook for beginning students. The volume, which explains how classical Japanese is related to modern Japanese, includes detailed explanations of basic grammar, including helpful, easy-to-use tables of grammatical forms; annotated excerpts from classical premodern texts. Classical Japanese: A Grammar - Exercise Answers and Tables (ISBN: 978-0-231-13530-6) is now available for purchase as a separate volume.

Molekulare Zellbiologie


Author: Arnold Berk,David Baltimore,Harvey Lodish,James Darnell,Paul Matsudaira,S. Lawrence Zipursky
Publisher: Walter de Gruyter
ISBN: 3110810573
Category: Science
Page: 1491
View: 5091

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Insect Molecular Genetics

An Introduction to Principles and Applications
Author: Marjorie A. Hoy
Publisher: Academic Press
ISBN: 0240821319
Category: Science
Page: 838
View: 7677

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Insect Molecular Genetics, Third Edition, summarizes and synthesizes two rather disparate disciplines—entomology and molecular genetics. This volume provides an introduction to the techniques and literature of molecular genetics; defines terminology; and reviews concepts, principles, and applications of these powerful tools. The world of insect molecular genetics, once dominated by Drosophila, has become much more diverse, especially with the sequencing of multiple arthropod genomes (from spider mites to mosquitoes). This introduction includes discussion of honey bees, mosquitoes, flour beetles, silk moths, fruit flies, aphids, house flies, kissing bugs, cicadas, butterflies, tsetse flies and armyworms. This book serves as both a foundational text and a review of a rapidly growing literature. With fully revised and updated chapters, the third edition will be a valuable addition to the personal libraries of entomologists, geneticists, and molecular biologists. Up-to-date references to important review articles, websites, and seminal citations in the disciplines Well crafted and instructive illustrations integral to explaining the techniques of molecular genetics Glossary of terms to help beginners learn the vocabulary of molecular biology

Philosophy of Experimental Biology


Author: Marcel Weber
Publisher: Cambridge University Press
ISBN: 9781139453912
Category: Science
Page: N.A
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Philosophy of Experimental Biology explores some central philosophical issues concerning scientific research in experimental biology, including genetics, biochemistry, molecular biology, developmental biology, neurobiology, and microbiology. It seeks to make sense of the explanatory strategies, concepts, ways of reasoning, approaches to discovery and problem solving, tools, models and experimental systems deployed by scientific life science researchers and also integrates developments in historical scholarship, in particular the New Experimentalism. It concludes that historical explanations of scientific change that are based on local laboratory practice need to be supplemented with an account of the epistemic norms and standards that are operative in science. This book should be of interest to philosophers and historians of science as well as to scientists.

Towards a Theory of Development


Author: Alessandro Minelli,Thomas Pradeu
Publisher: OUP Oxford
ISBN: 0191651184
Category: Science
Page: 320
View: 2162

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Is it possible to explain and predict the development of living things? What is development? Articulate answers to these seemingly innocuous questions are far from straightforward. To date, no systematic, targeted effort has been made to construct a unifying theory of development. This novel work offers a unique exploration of the foundations of ontogeny by asking how the development of living things should be understood. It explores the key concepts of developmental biology, asks whether general principles of development can be discovered, and examines the role of models and theories. The two editors (one a biologist with long interest in the theoretical aspects of his discipline, the other a philosopher of science who has mainly worked on biological systems) have assembled a team of leading contributors who are representative of the scientific and philosophical community within which a diversity of thoughts are growing, and out of which a theory of development may eventually emerge. They analyse a wealth of approaches to concepts, models and theories of development, such as gene regulatory networks, accounts based on systems biology and on physics of soft matter, the different articulations of evolution and development, symbiont-induced development, as well as the widely discussed concepts of positional information and morphogenetic field, the idea of a 'programme' of development and its critiques, and the long-standing opposition between preformationist and epigenetic conceptions of development. Towards a Theory of Development is primarily aimed at students and researchers in the fields of 'evo-devo', developmental biology, theoretical biology, systems biology, biophysics, and the philosophy of science.

Anschauung denken

Zum Ansatz einer Morphologie des Unmittelbaren
Author: Olaf Breidbach,Federico Vercellone
Publisher: Wilhelm Fink Verlag
ISBN: 3770552490
Category: Aesthetics, Modern
Page: 182
View: 1849

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Bilder schauen wir an, unser Anschauen scheint durch diese Bilder geführt. In der immer stärker anwachsenden Flut solcher Bilder scheint unser Denken mehr und mehr durch dieses Anschauen bestimmt. Dabei offeriert diese Flut meist nur ein Spiel mit bekannten Formen, die variiert und in vielleicht verblüffender Weise präsentiert werden. Oft sind es dabei aber nur Illustrationen, die einen bekannten Gedanken untersetzen. Wo die Bilder aber in Neuland führen, wo sie uns etwas entdecken lassen, ist die Situation anders. Das Bild – und dies interessiert im vorliegenden Band – hat aber seine eigene Logik. Diese Logik ist nicht einfach die, die wir mit dem Bild illustrieren. Es formt sich nach den uns eigenen Anschauungen und leitet uns dann auch in unserem Denken über die Dinge. In ihm meinen wir denn auch Neues entdecken zu können, auf etwas verwiesen zu sein, was wir uns eben nicht schon immer gedacht haben. Wie kommen wir aber eigentlich an solch Neues, wie können wir etwas erkennen, von dem wir noch keinen Begriff haben? Werden wir im Denken solcher Neuigkeiten durch die Anschauung geführt? Greifen wir hier vor das aus, was wir schon begriffen haben? Wenn dies so ist, müssen wir Anschauungen zu denken lernen. Anschauungen zu denken, heißt dann aber nicht einfach zu illustrieren, was wir begriffen haben. Anschauung zu denken, heißt, vor den Begriff zu schauen. Das vorliegende Buch sucht hier nach ersten Antworten.

Morphomechanics of Development


Author: Lev V. Beloussov
Publisher: Springer
ISBN: 3319139908
Category: Science
Page: 195
View: 3279

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This book outlines a unified theory of embryonic development, assuming morphogenesis to be a multi-level process including self-organizing steps while also obeying general laws. It is shown how molecular mechanisms generate mechanical forces, which in the long run lead to morphological changes. Questions such as how stress-mediated feedback acts at the cellular and supra-cellular levels and how executive and regulatory mechanisms are mutually dependent are addressed, while aspects of collective cell behavior and the morphogenesis of plants are also discussed. The morphomechanical approach employed in the book is based on the general principles of self-organization theory.

Animal Evolution

Genomes, Fossils, and Trees
Author: Maximilian J. Telford,D. Timothy J. Littlewood
Publisher: Oxford University Press
ISBN: 0199549427
Category: Science
Page: 245
View: 9157

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Describing and understanding the evolution of the diversity of bodyplans is a major goal of evolutionary biology. Taking a modern, integrated approach to this question, a group of leading researchers describe how modern techniques and disciplines have been combined, resulting in a dramatic renaissance in the study of animal evolution.

General and Systematic Pathology E-Book


Author: James C. E. Underwood,Simon S Cross
Publisher: Elsevier Health Sciences
ISBN: 143772874X
Category: Medical
Page: 860
View: 968

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This highly acclaimed textbook is written specifically for students of medicine and related health science subjects. It progresses from a review of general pathology principles and disease mechanisms through detailed discussions of the pathologic entities associated with each organ system. Nearly 700 full-color photographs and pathology slides bring the content to life. The fifth edition features extensive updates throughout to reflect the latest discoveries in cellular and molecular pathology, and offers a web site that presents self-assessment material and illustrated clinical case studies. Contents perfectly matches needs on medical students. Very clinical approach matches integrated courses. Extensive International Advisory Board validates contents. Each organ system chapter begins with a brief review of normal structure and function, emphasizing aspects that are important to an understanding of the subsequently discussed disease processes. Offers a superb collection of clinical photographs, histopathology images, and graphics, approximately 700 in all, that richly depict the appearance of both healthy and diseased tissues. New co-editor, Dr Simon Cross. Structure of chapters revised to make the book much easier to use during courses that are problem- or case-based. Several new contributors and re-written chapters. Expanded International Advisory Board.

Behavioral Genetics of the Fly (Drosophila Melanogaster)


Author: Josh Dubnau
Publisher: Cambridge University Press
ISBN: 1139952196
Category: Science
Page: N.A
View: 5021

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The common fruit fly - Drosophila melanogaster - has been the subject of genetics research since the early twentieth century. The complete genomic sequence of Drosophila was published in 2000 and it is still the model organism par excellence for the experimental study of biological phenomena and processes. It is also by far the best model for studying gene function in mammals, including humans. Presenting state-of-the-art studies on the behaviour of Drosophila, this volume discusses normal and pathological models of neurobehavioral disorders and encompasses the specialised methods that have been used, from anatomical, histological, immunohistological and neurophysiological to genomic, genetic and behavioural assays. A comprehensive and thorough reference, this volume is a valuable resource for students and researchers alike across several disciplines of life sciences, including behavioral genetics, neurogenetics, behavioral neuroscience, molecular biology, evolutionary biology and population biology.

The Art of Genes : How Organisms Make Themselves

How Organisms Make Themselves
Author: Enrico Coen
Publisher: Oxford University Press, UK
ISBN: 0191587672
Category: Science
Page: 396
View: 5638

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How is a fertilized egg able to turn itself into an adult? Through a highly original synthesis of science and art, this book vividly describes the recent revolution in our understanding of how plants and animals develop, and the fresh insights this gives us into the nature of evolution and human creativity. - ;How is a tiny fertilised egg able to turn itself into a human being? How can an acorn transform itself into an oak tree? Through a highly original synthesis of science and art, this book vividly describes the recent revolution in our understanding of how plants and animals develop. Drawing on a wide range of material -- from flowers growing petals instead of sex organs, and flies that develop an extra pair of wings, to works by Leonardo and Magritte -- it explains the language and meaning of genes, in an entertaining way that is both accurate and accessible to the general reader. It shows how an organism develops through an interactive dialogue in which there is no clear separation between plan and execution, much as an artist might paint a picture. By explaining how this process has arisen, the book arrives at fresh and exciting insights into the nature of evolution, development and human creativity. -

Evo Devo

das neue Bild der Evolution
Author: Sean B. Carroll
Publisher: N.A
ISBN: 9783940432155
Category:
Page: 318
View: 3879

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Gene Expression at the Beginning of Animal Development


Author: Melvin L. DePamphilis
Publisher: Elsevier
ISBN: 9780444510488
Category: Medical
Page: 280
View: 8444

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The beginning of life may be a miracle to some, and a mystery to others, but it is certainly one of the most exciting and perhaps controversial fields of scientific investigation in the 21st century. Among the metazoa, life begins when an egg is fertilized by a sperm. The sperm provides a genetic blueprint from the father and perhaps some critical proteins. The egg provides a genetic blueprint from the mother together with a large reservoir of mRNAs and proteins that are required for DNA replication, cell division and the onset of zygotic gene expression. All of the thousands of genes in these two mature gametes are transcriptionally silent and remain so until fertilization. This work focuses on three biological systems, providing the reader with a clear understanding of the current state of affairs, and the ability to identify common principles as well as critical differences that are responsible for beginning the process of animal development. The essays presented will be of practical value to all those who are interested in improving fertilization in vitro, in designing novel methods of contraception, in developing preimplantation genetic diagnosis for various diseases, in cloning animals by transplanting nuclei from adult cells to an enucleated egg, and in the application of embryonic stem cells to curing genetic diseases or replacing damaged tissues. But above all, this volume is offered to those who simply have an insatiable curiosity about life and its beginnings.

Eine kurze Geschichte der Menschheit


Author: Yuval Noah Harari
Publisher: DVA
ISBN: 364110498X
Category: History
Page: 528
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Krone der Schöpfung? Vor 100 000 Jahren war der Homo sapiens noch ein unbedeutendes Tier, das unauffällig in einem abgelegenen Winkel des afrikanischen Kontinents lebte. Unsere Vorfahren teilten sich den Planeten mit mindestens fünf weiteren menschlichen Spezies, und die Rolle, die sie im Ökosystem spielten, war nicht größer als die von Gorillas, Libellen oder Quallen. Vor 70 000 Jahren dann vollzog sich ein mysteriöser und rascher Wandel mit dem Homo sapiens, und es war vor allem die Beschaffenheit seines Gehirns, die ihn zum Herren des Planeten und zum Schrecken des Ökosystems werden ließ. Bis heute hat sich diese Vorherrschaft stetig zugespitzt: Der Mensch hat die Fähigkeit zu schöpferischem und zu zerstörerischem Handeln wie kein anderes Lebewesen. Anschaulich, unterhaltsam und stellenweise hochkomisch zeichnet Yuval Harari die Geschichte des Menschen nach und zeigt alle großen, aber auch alle ambivalenten Momente unserer Menschwerdung.

The Biotech Investor

How to Profit from the Coming Boom in Biotechnology
Author: Tom Abate
Publisher: Times Books
ISBN: 146685121X
Category: Business & Economics
Page: 304
View: 8847

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A sophisticated investor's practical tool kit for analyzing the science, business, opportunities, and risks in the century's most promising industry The world is entering a biotechnology boom-but only informed investors will prosper in the incredibly complex biotech business. Separating the bioengineered wheat from the chaff, San Francisco Chronicle science and technology columnist Tom Abate, one of the top objective authorities on biotech, gives investors the analytical foundation to understand the science, finances, time horizon, and technological and commercial potential of this burgeoning industry. In The Biotech Investor, Abate provides sophisticated business analysis, guidelines for assessing company leadership, easy-to-digest reports from the labs, and indispensable investor tools and metrics. He explains how breaking news, medical conferences, U.S. Food and Drug Administration approvals, and the patent process affect investing strategies. Finally, he looks beyond medicine to review the financial opportunities presented by biotechnology advances in everything from agriculture to jean manufacturing, and shows investors how to identify "coattail" industries such as instrumentation and software development that will benefit from biotech successes. The Biotech Investor is the comprehensive, expert source for successful and intelligent investing in one of the twenty-first century's most promising industries.

A Natural History of Families


Author: LS Forbes,Scott Forbes
Publisher: Princeton University Press
ISBN: 9780691094823
Category: Science
Page: 231
View: 4832

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Why do baby sharks, hyenas, and pelicans kill their siblings? Why do beetles and mice commit infanticide? Why are twins and birth defects more common in older human mothers? A Natural History of Families concisely examines what behavioral ecologists have discovered about family dynamics and what these insights might tell us about human biology and behavior. Scott Forbes's engaging account describes an uneasy union among family members in which rivalry for resources often has dramatic and even fatal consequences. In nature, parents invest resources and control the allocation of resources among their offspring to perpetuate their genetic lineage. Those families sometimes function as cooperative units, the nepotistic and loving havens we choose to identify with. In the natural world, however, dysfunctional familial behavior is disarmingly commonplace. While explaining why infanticide, fratricide, and other seemingly antisocial behaviors are necessary, Forbes also uncovers several surprising applications to humans. Here the conflict begins in the moments following conception as embryos struggle to wrest control of pregnancy from the mother, and to wring more nourishment from her than she can spare, thus triggering morning sickness, diabetes, and high blood pressure. Mothers, in return, often spontaneously abort embryos with severe genetic defects, allowing for prenatal quality control of offspring. Using a broad sweep of entertaining examples culled from the world of animals and humans, A Natural History of Families is a lively introduction to the behavioral ecology of the family.

Dein Körper: Das Missing Manual


Author: Matthew MacDonald
Publisher: O'Reilly Germany
ISBN: 3897219646
Category: Health & Fitness
Page: 324
View: 9141

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Wussten Sie, dass Sie Ihre äußere Hautschicht häufiger wechseln als eine Schlange? Oder dass Sie ohne bestimmte Arten von Bakterien anfälliger für Krankheiten und Allergien wären? Auf Basis aktuellster physiologischer und neurophysiologischer Erkenntnisse erklärt Matthew MacDonald präzise, verständlich und unterhaltsam alle wichtigen Körperfunktionen, gibt praktische Tipps, wie Sie Ihre „Hardware“ in Schuss halten, und räumt mit gängigen Vorurteilen auf. Aus dem Inhalt: - Ihre Haut. Warum die erste Verteidigungslinie Ihres Körpers aus toten Zellen besteht, wie Muttermale und Falten entstehen und was Antitranspirants gegen Körpergeruch ausrichten können. - Fett. Weshalb Ihr Körper Fett braucht, wie es gespeichert wird und warum Modediäten nichts bringen. - Ihr Herz. Wie Sie das Herzinfarktrisiko senken und was ein gutes Ausdauertraining ausmacht. - Ihr Verdauungssystem. Aus welchen Abschnitten Ihr gut 9 Meter langer Verdauungstrakt besteht und warum Ballaststoffe dort willkommen sind. - Ihr Immunsystem. Wie Ihr Körper sich gegen Eindringlinge wehrt, welche Bakterien und Viren sich bei Ihnen wohlfühlen und was normale Zellen dazu bringt, sich in Krebszellen zu verwandeln. - Sex und Fortpflanzung. Was männliche und weibliche Geschlechtsorgane auszeichnet sowie alles Wissenswerte über Fruchtbarkeit, weibliche Lust und die männliche Fixierung auf die Größe. - Alter und Tod. Warum wir altern, wie Sie möglichst lange möglichst fit bleiben und wie wir schließlich sterben.