Statistical Methods for Hospital Monitoring with R


Author: Anthony Morton,Kerrie L. Mengersen,Geoffrey Playford,Michael Whitby
Publisher: John Wiley & Sons
ISBN: 1118639170
Category: Medical
Page: 432
View: 5055

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Hospitals monitoring is becoming more complex and is increasingboth because staff want their data analysed and because ofincreasing mandated surveillance. This book provides a suiteof functions in R, enabling scientists and data analysts working ininfection management and quality improvement departments inhospitals, to analyse their often non-independent data which isfrequently in the form of trended, over-dispersed and sometimesauto-correlated time series; this is often difficult to analyseusing standard office software. This book provides much-needed guidance on data analysis using Rfor the growing number of scientists in hospital departments whoare responsible for producing reports, and who may have limitedstatistical expertise. This book explores data analysis using R and is aimed atscientists in hospital departments who are responsible forproducing reports, and who are involved in improving safety.Professionals working in the healthcare quality and safetycommunity will also find this book of interest Statistical Methods for Hospital Monitoring with R: Provides functions to perform quality improvement and infectionmanagement data analysis. Explores the characteristics of complex systems, such asself-organisation and emergent behaviour, along with theirimplications for such activities as root-cause analysis and thePareto principle that seek few key causes of adverse events. Provides a summary of key non-statistical aspects of hospitalsafety and easy to use functions. Provides R scripts in an accompanying web site enablinganalyses to be performed by the reader ahref="http://www.wiley.com/go/hospital_monitoring"http://www.wiley.com/go/hospital_monitoring/a Covers issues that will be of increasing importance in thefuture, such as, generalised additive models, and complex systems,networks and power laws.

Statistical Methods for Evaluating Safety in Medical Product Development


Author: A. Lawrence Gould
Publisher: John Wiley & Sons
ISBN: 1118763106
Category: Medical
Page: 392
View: 1843

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This book gives professionals in clinical research valuable information on the challenging issues of the design, execution, and management of clinical trials, and how to resolve these issues effectively. It also provides understanding and practical guidance on the application of contemporary statistical methods to contemporary issues in safety evaluation during medical product development. Each chapter provides sufficient detail to the reader to undertake the design and analysis of experiments at various stages of product development, including comprehensive references to the relevant literature. Provides a guide to statistical methods and application in medical product development Assists readers in undertaking design and analysis of experiments at various stages of product development Features case studies throughout the book, as well as, SAS and R code

Data Monitoring Committees in Clinical Trials

A Practical Perspective
Author: Susan S. Ellenberg,Thomas R. Fleming,David L. DeMets
Publisher: Wiley
ISBN: 1119512654
Category: Medical
Page: 496
View: 820

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­The authoritative guide for Data Monitoring Committees—fully revised and updated The number of clinical trials sponsored by government agencies and pharmaceutical companies has grown in recent years, prompting an increased need for interim monitoring of data on safety and efficacy. Data Monitoring Committees (DMCs) are an essential component of many clinical trials, safeguarding trial participants and protecting the credibility and validity of the study. Data Monitoring Committees in Clinical Trials: A Practical Perspective, 2nd Edition offers practical advice for those managing and conducting clinical trials and serving on Data Monitoring Committees, providing a practical overview of the establishment, purpose, and responsibilities of these committees. Examination of topics such as the composition and independence of DMCs, statistical, philosophical and ethical considerations, and determining when a DMC is needed, presents readers with a comprehensive foundational knowledge of clinical trial oversight. Providing recent examples to illustrate DMC principles, this fully-updated guide reflects current developments and practices in clinical trial oversight and offers expanded coverage of emerging issues and challenges in the field. This new second edition covers the most current information on DMC policies, issues in monitoring trials using new designs, and recent trial publications relevant to DMC decision-making. • Presents practical advice for those managing and conducting clinical trials and serving on Data Monitoring Committees • Illustrates the types of challenging issues Data Monitoring Committees face in practical situations • Provides updated and expanded coverage of topics including regulatory and funding agency guidelines and trial designs and their associated demands and limitations • Includes a new chapter addressing legal issues that affect DMC members and discusses general litigation concerns relevant to clinical research • Expands treatment of current journal publications addressing DMC issues Data Monitoring Committees in Clinical Trials: A Practical Perspective, 2nd Edition is a must-have text for anyone engaged in DMC activities as well as trial sponsors, clinical trial researchers, regulatory and bioethics professionals, and those associated with clinical trials in academic, government and industry settings.

Modern Industrial Statistics

with applications in R, MINITAB and JMP
Author: Ron S. Kenett,Shelemyahu Zacks,Daniele Amberti
Publisher: John Wiley & Sons
ISBN: 1118763696
Category: Mathematics
Page: 592
View: 2063

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Fully revised and updated, this book combines a theoretical background with examples and references to R, MINITAB and JMP, enabling practitioners to find state-of-the-art material on both foundation and implementation tools to support their work. Topics addressed include computer-intensive data analysis, acceptance sampling, univariate and multivariate statistical process control, design of experiments, quality by design, and reliability using classical and Bayesian methods. The book can be used for workshops or courses on acceptance sampling, statistical process control, design of experiments, and reliability. Graduate and post-graduate students in the areas of statistical quality and engineering, as well as industrial statisticians, researchers and practitioners in these fields will all benefit from the comprehensive combination of theoretical and practical information provided in this single volume. Modern Industrial Statistics: With applications in R, MINITAB and JMP: Combines a practical approach with theoretical foundations and computational support. Provides examples in R using a dedicated package called MISTAT, and also refers to MINITAB and JMP. Includes exercises at the end of each chapter to aid learning and test knowledge. Provides over 40 data sets representing real-life case studies. Is complemented by a comprehensive website providing an introduction to R, and installations of JMP scripts and MINITAB macros, including effective tutorials with introductory material: www.wiley.com/go/modern_industrial_statistics.

Applied Mixed Models in Medicine


Author: Helen Brown,Robin Prescott
Publisher: John Wiley & Sons
ISBN: 1118778243
Category: Medical
Page: 536
View: 768

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A fully updated edition of this key text on mixed models,focusing on applications in medical research The application of mixed models is an increasingly popular wayof analysing medical data, particularly in the pharmaceuticalindustry. A mixed model allows the incorporation of both fixed andrandom variables within a statistical analysis, enabling efficientinferences and more information to be gained from the data. Therehave been many recent advances in mixed modelling, particularlyregarding the software and applications. This third edition ofBrown and Prescott’s groundbreaking text provides an updateon the latest developments, and includes guidance on the use ofcurrent SAS techniques across a wide range of applications. Presents an overview of the theory and applications of mixedmodels in medical research, including the latest developments andnew sections on incomplete block designs and the analysis ofbilateral data. Easily accessible to practitioners in any area where mixedmodels are used, including medical statisticians andeconomists. Includes numerous examples using real data from medical andhealth research, and epidemiology, illustrated with SAS code andoutput. Features the new version of SAS, including new graphics formodel diagnostics and the procedure PROC MCMC. Supported by a website featuring computer code, data sets, andfurther material. This third edition will appeal to applied statisticians workingin medical research and the pharmaceutical industry, as well asteachers and students of statistics courses in mixed models. Thebook will also be of great value to a broad range of scientists,particularly those working in the medical and pharmaceuticalareas.

Statistical Methods for Healthcare Performance Monitoring


Author: Alex Bottle,Paul Aylin
Publisher: CRC Press
ISBN: 1482246104
Category: Mathematics
Page: 269
View: 2280

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Healthcare is important to everyone, yet large variations in its quality have been well documented both between and within many countries. With demand and expenditure rising, it’s more crucial than ever to know how well the healthcare system and all its components – from staff member to regional network – are performing. This requires data, which inevitably differ in form and quality. It also requires statistical methods, the output of which needs to be presented so that it can be understood by whoever needs it to make decisions. Statistical Methods for Healthcare Performance Monitoring covers measuring quality, types of data, risk adjustment, defining good and bad performance, statistical monitoring, presenting the results to different audiences and evaluating the monitoring system itself. Using examples from around the world, it brings all the issues and perspectives together in a largely non-technical way for clinicians, managers and methodologists. Statistical Methods for Healthcare Performance Monitoring is aimed at statisticians and researchers who need to know how to measure and compare performance, health service regulators, health service managers with responsibilities for monitoring performance, and quality improvement scientists, including those involved in clinical audits.

Henry's Clinical Diagnosis and Management by Laboratory Methods E-Book


Author: Richard A. McPherson,Matthew R. Pincus
Publisher: Elsevier Health Sciences
ISBN: 1455726842
Category: Medical
Page: 1568
View: 8030

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Recognized as the definitive book in laboratory medicine since 1908, Henry’s Clinical Diagnosis and Management by Laboratory Methods, edited by Richard A. McPherson, MD and Matthew R. Pincus, MD, PhD, is a comprehensive, multidisciplinary pathology reference that gives you state-of-the-art guidance on lab test selection and interpretation of results. Revisions throughout keep you current on the latest topics in the field, such as biochemical markers of bone metabolism, clinical enzymology, pharmacogenomics, and more! A user-friendly full-color layout puts all the latest, most essential knowledge at your fingertips. Update your understanding of the scientific foundation and clinical application of today's complete range of laboratory tests. Get optimal test results with guidance on error detection, correction, and prevention as well as cost-effective test selection. Reference the information you need quickly and easily thanks to a full-color layout, many new color illustrations and visual aids, and an organization by organ system. Master all the latest approaches in clinical laboratory medicine with new and updated coverage of: the chemical basis for analyte assays and common interferences; lipids and dyslipoproteinemia; markers in the blood for cardiac injury evaluation and related stroke disorders; coagulation testing for antiplatelet drugs such as aspirin and clopidogrel; biochemical markers of bone metabolism; clinical enzymology; hematology and transfusion medicine; medical microbiology; body fluid analysis; and many other rapidly evolving frontiers in the field. Effectively monitor the pace of drug clearing in patients undergoing pharmacogenomic treatments with a new chapter on this groundbreaking new area. Apply the latest best practices in clinical laboratory management with special chapters on organization, work flow, quality control, interpretation of results, informatics, financial management, and establishing a molecular diagnostics laboratory. Confidently prepare for the upcoming recertification exams for clinical pathologists set to begin in 2016.

Statistical Methods for Survival Trial Design

With Applications to Cancer Clinical Trials Using R
Author: Jianrong Wu
Publisher: CRC Press
ISBN: 0429892934
Category: Mathematics
Page: 257
View: 1658

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Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint. Traditional cancer trial designs with time-to-event endpoints are often limited to the exponential model or proportional hazards model. In practice, however, those model assumptions may not be satisfied for long-term survival trials. This book is the first to cover comprehensively the many newly developed methodologies for survival trial design, including trial design under the Weibull survival models; extensions of the sample size calculations under the proportional hazard models; and trial design under mixture cure models, complex survival models, Cox regression models, and competing-risk models. A general sequential procedure based on the sequential conditional probability ratio test is also implemented for survival trial monitoring. All methodologies are presented with sufficient detail for interested researchers or graduate students.

Health Surveys and Related Studies


Author: M. Alderson,R. Dowie
Publisher: Elsevier
ISBN: 1483285502
Category: Social Science
Page: 356
View: 984

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This review describes the statistics of health care derived from non-routine sources. The chapter on need describes local and national population studies and general morbidity surveys as well as covering a range of specific problem studies. Statistics reflecting unmet demand are described as they relate to the various stages of medical care from primary medical to patient care. Resources are described in statistics of facilities as well as the various classes of manpower employed, and the uses of services chapter covers all community and hospital services. Studies which evaluate medical care are divided into those which reflect accessibility and acceptability as well as outcome of care and satisfaction of patients, families and staff. An introduction contains a discussion on the application of statistics and the concluding chapter looks towards a future unified health information system.

Understanding Nursing Research

Building an Evidence-Based Practice
Author: Susan K. Grove,Jennifer R. Gray,Nancy Burns
Publisher: Elsevier Health Sciences
ISBN: 0323293328
Category: Medical
Page: 544
View: 4390

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As the bestselling nursing research text, Understanding Nursing Research: Building an Evidence-Based Practice, 6th Edition offers unique insights into understanding, appraising, and applying published research to evidence-based practice. It is known for its authoritative content, time-tested systematic approach, and unique research example format newly redesigned for the sixth edition to better demonstrate how the steps of the research process relate to evidence-based nursing. "This would be excellent for student nurses, nurses new to research or any nurse with an interest in research." Reviewed by: Helen Reeves, St Giles Walsall Hospice on behalf of Nursing Times, December 2015 Authoritative content is written by two of the true pioneers in nursing research, who offer unique, first-hand insights into the field. Research examples provide practice in working with published studies, with many of the examples including Critical Appraisal and Implications for Practice sections. Clear, step-by-step organization introduces the research process and demonstrates how this systematic framework relates to evidence-based practice. Strong emphasis on evidence-based practice helps you develop skills in studying and appraising published research, so you are prepared for your role in working with research evidence. Critical Appraisal Guidelines boxes provide step-by-step guidance in appraising published research studies. Emphasis on critical appraisal versus critique reflects contemporary usage in nursing research and evidence-based practice. Balanced coverage of qualitative research prepares you to approach research questions and clinical questions with an unbiased view of the researcher's methodology. Presentation of two different appraisal processes covers both the traditional in-depth critical appraisal process that prepares you for graduate-level work in research, and the concise, practice-focused research appraisal process that equips you for quick and accurate evaluation of the applicability of research findings to clinical practice. NEW! Redesigned research example format includes research examples have been thoroughly redesigned with a clear hierarchy of subcategories. NEW! Improved focus on need-to-know content and greater use of bulleting, creative illustrations, and tables, employs a more consistent, streamlined approach from chapter to chapter. NEW! Updated research examples ensure you are learning through the most clinically relevant topics and studies. NEW! Detailed directions on how to critically appraise research syntheses — such as systematic reviews, meta-analyses, meta-syntheses, and mixed-methods systematic reviews — increase your understanding of the types of research syntheses conducted in nursing and how to determine the quality of these syntheses and the relevance of their findings for practice. NEW! A unique emphasis on QSEN, aided by the input of a QSEN consultant, increases the book’s relevance to national curriculum standards and promotes the safe practice of nursing by using the most current research. NEW! Chapter on the Enhanced Literature Review provides guidelines for structure of reviews written for different purposes. NEW! More practically focused chapter on Outcomes Research better addresses the trending topic of outcomes research. NEW! Expanded coverage of mixed-methods research and translational research responds to the growing emphasis on these research emphases. NEW! Expanded coverage of cultural competency and cultural validity

Clinical Pharmacology


Author: Morris J. Brown,Pankaj Sharma,Peter N. Bennett
Publisher: Elsevier Health Sciences
ISBN: 0702051136
Category: Medical
Page: 640
View: 1980

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A thorough knowledge of pharmacological and therapeutic principles is vital if drugs are to be used safely and effectively for increasingly informed patients. Those who clearly understand how drugs get into the body, how they produce their effects, what happens to them in the body, and how evidence of their therapeutic effect is assessed, will choose drugs more skilfully, and use them more safely and successfully than those who do not. Now in a fully revised 11th edition, Clinical Pharmacology is essential reading for undergraduate medical students, junior doctors and anyone concerned with evidence-based drug therapy. Introductory first three sections cover general principle of clinical pharmacology; five subsequent sections cover drug treatment of disease organised by body system. Retains approachable style set by the original author, Professor Laurence. Emphasis throughout is on evidence-based and safe drug prescribing. Indian Advisory Board will ensure content reflects the needs of the devloping world.

Principles and Practice of Hospital Medicine


Author: Sylvia McKean,Daniel Dressler,John Ross
Publisher: McGraw Hill Professional
ISBN: 0071603891
Category: Medical
Page: 2310
View: 4209

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"Presented in full color and enhanced by more than 700 illustrations, this authoritative text provides a background in all the important clinical, organizational, and administrative areas now required for the practice of hospital medicine. The goal of the book is provide trainees, junior and senior clinicians, and other professionals with a comprehensive resource that they can use to improve care processes and performance in the hospitals that serve their communities. Each chapter opens with boxed Key Clinical Questions that are addressed in the text and hundreds of tables encapsulate important information. Case studies demonstrate how to apply the concepts covered in the text directly to the hospitalized patient."--amazon.com.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics - E-Book


Author: Carl A. Burtis,Edward R. Ashwood,David E. Bruns
Publisher: Elsevier Health Sciences
ISBN: 1455759422
Category: Medical
Page: 2256
View: 6049

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As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors, Ann Gronowski, W. Greg Miller, Michael Oellerich, Francois Rousseau, Mitchell Scott, and Karl Voelkerding, lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.

Regression

Modelle, Methoden und Anwendungen
Author: Ludwig Fahrmeir,Thomas Kneib,Stefan Lang
Publisher: Springer-Verlag
ISBN: 3642018378
Category: Business & Economics
Page: 502
View: 4660

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In dem Band beschreiben die Autoren erstmals klassische Regressionsansätze und moderne nicht- und semiparametrische Methoden in einer integrierten und anwendungsorientierten Form. Um Lesern die Analyse eigener Fragestellungen zu ermöglichen, demonstrieren sie die praktische Anwendung der Konzepte und Methoden anhand ausführlicher Fallstudien. Geeignet für Studierende der Statistik sowie für Wissenschaftler und Praktiker, zum Beispiel in den Wirtschafts- und Sozialwissenschaften, der Bioinformatik und -statistik, Ökonometrie und Epidemiologie.

Intravascular Infusion Systems

Principles and Practice
Author: R. Ausman
Publisher: Springer Science & Business Media
ISBN: 9401163413
Category: Medical
Page: 208
View: 2974

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This book has been written for use by health professionals, typically physicians, nurses, and pharmacists, who have a constant relationship with intravascular infusions. It is intended to provide information where appropriate and guidance when possible for the safe and effective use of parenteral fluids. For several years medical practitioners viewed 'i.v. fluids' rather casu ally. In as much as the solutions themselves seemed innocuous, these medications did not enjoy the respect given to more potent pharmaceuti cals. Intravenous fluid systems were commodities; purchase and use decisions for whole hospitals were placed in the domain of business office personnel. Any tendency toward cessation of 'in hospital manufacture' of solutions was driven by the adverse economics of costly equipment replacement rather than a desire to improve the quality of the product being administered to the patient. An event in 1971 which changed this environment involved an epidemic of patient infections which were related to a specific solution system. Almost immediately there was an enhanced involvement of health care people who assumed responsibility for i.v. fluids and their use. This intensity of interest has not diminished. A few years ago publication of this book would not have been possible because there was no audience for it. No one was interested. Now there are many people who want to know and want to become involved. It is my hope those who read this book will not be disappointed.

Low-level Radiation

Biological Interactions, Risks and Benefits : a Bibliography
Author: N.A
Publisher: N.A
ISBN: N.A
Category: Radiation
Page: 731
View: 1678

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