Statistical Methods for Hospital Monitoring with R


Author: Anthony Morton,Kerrie L. Mengersen,Geoffrey Playford,Michael Whitby
Publisher: John Wiley & Sons
ISBN: 1118639170
Category: Medical
Page: 432
View: 8403

Continue Reading →

Hospitals monitoring is becoming more complex and is increasing both because staff want their data analysed and because of increasing mandated surveillance. This book provides a suite of functions in R, enabling scientists and data analysts working in infection management and quality improvement departments in hospitals, to analyse their often non-independent data which is frequently in the form of trended, over-dispersed and sometimes auto-correlated time series; this is often difficult to analyse using standard office software. This book provides much-needed guidance on data analysis using R for the growing number of scientists in hospital departments who are responsible for producing reports, and who may have limited statistical expertise. This book explores data analysis using R and is aimed at scientists in hospital departments who are responsible for producing reports, and who are involved in improving safety. Professionals working in the healthcare quality and safety community will also find this book of interest Statistical Methods for Hospital Monitoring with R: Provides functions to perform quality improvement and infection management data analysis. Explores the characteristics of complex systems, such as self-organisation and emergent behaviour, along with their implications for such activities as root-cause analysis and the Pareto principle that seek few key causes of adverse events. Provides a summary of key non-statistical aspects of hospital safety and easy to use functions. Provides R scripts in an accompanying web site enabling analyses to be performed by the reader http://www.wiley.com/go/hospital_monitoring Covers issues that will be of increasing importance in the future, such as, generalised additive models, and complex systems, networks and power laws.

Statistical Methods for Evaluating Safety in Medical Product Development


Author: A. Lawrence Gould
Publisher: John Wiley & Sons
ISBN: 1118763106
Category: Medical
Page: 392
View: 8340

Continue Reading →

This book gives professionals in clinical research valuable information on the challenging issues of the design, execution, and management of clinical trials, and how to resolve these issues effectively. It also provides understanding and practical guidance on the application of contemporary statistical methods to contemporary issues in safety evaluation during medical product development. Each chapter provides sufficient detail to the reader to undertake the design and analysis of experiments at various stages of product development, including comprehensive references to the relevant literature. Provides a guide to statistical methods and application in medical product development Assists readers in undertaking design and analysis of experiments at various stages of product development Features case studies throughout the book, as well as, SAS and R code

Modern Industrial Statistics

with applications in R, MINITAB and JMP
Author: Ron S. Kenett,Shelemyahu Zacks,Daniele Amberti
Publisher: John Wiley & Sons
ISBN: 1118763696
Category: Mathematics
Page: 592
View: 9965

Continue Reading →

Fully revised and updated, this book combines a theoretical background with examples and references to R, MINITAB and JMP, enabling practitioners to find state-of-the-art material on both foundation and implementation tools to support their work. Topics addressed include computer-intensive data analysis, acceptance sampling, univariate and multivariate statistical process control, design of experiments, quality by design, and reliability using classical and Bayesian methods. The book can be used for workshops or courses on acceptance sampling, statistical process control, design of experiments, and reliability. Graduate and post-graduate students in the areas of statistical quality and engineering, as well as industrial statisticians, researchers and practitioners in these fields will all benefit from the comprehensive combination of theoretical and practical information provided in this single volume. Modern Industrial Statistics: With applications in R, MINITAB and JMP: Combines a practical approach with theoretical foundations and computational support. Provides examples in R using a dedicated package called MISTAT, and also refers to MINITAB and JMP. Includes exercises at the end of each chapter to aid learning and test knowledge. Provides over 40 data sets representing real-life case studies. Is complemented by a comprehensive website providing an introduction to R, and installations of JMP scripts and MINITAB macros, including effective tutorials with introductory material: www.wiley.com/go/modern_industrial_statistics.

Crossover Designs

Testing, Estimation, and Sample Size
Author: Kung-Jong Lui
Publisher: John Wiley & Sons
ISBN: 1119114691
Category: Medical
Page: 248
View: 8075

Continue Reading →

A comprehensive and practical resource for analyses of crossover designs For ethical reasons, it is vital to keep the number of patients in a clinical trial as low as possible. As evidenced by extensive research publications, crossover design can be a useful and powerful tool to reduce the number of patients needed for a parallel group design in studying treatments for non-curable chronic diseases. This book introduces commonly-used and well-established statistical tests and estimators in epidemiology that can easily be applied to hypothesis testing and estimation of the relative treatment effect for various types of data scale in crossover designs. Models with distribution-free random effects are assumed and hence most approaches considered here are semi-parametric. The book provides clinicians and biostatisticians with the exact test procedures and exact interval estimators, which are applicable even when the number of patients in a crossover trial is small. Systematic discussion on sample size determination is also included, which will be a valuable resource for researchers involved in crossover trial design. Key features: Provides exact test procedures and interval estimators, which are especially of use in small-sample cases. Presents most test procedures and interval estimators in closed-forms, enabling readers to calculate them by use of a pocket calculator or commonly-used statistical packages. Each chapter is self-contained, allowing the book to be used a reference resource. Uses real-life examples to illustrate the practical use of test procedures and estimators Provides extensive exercises to help readers appreciate the underlying theory, learn other relevant test procedures and understand how to calculate the required sample size. Crossover Designs: Testing, Estimation and Sample Size will be a useful resource for researchers from biostatistics, as well as pharmaceutical and clinical sciences. It can also be used as a textbook or reference for graduate students studying clinical experiments.

Applied Mixed Models in Medicine


Author: Helen Brown,Robin Prescott
Publisher: John Wiley & Sons
ISBN: 1118778243
Category: Medical
Page: 536
View: 7137

Continue Reading →

A fully updated edition of this key text on mixed models, focusing on applications in medical research The application of mixed models is an increasingly popular way of analysing medical data, particularly in the pharmaceutical industry. A mixed model allows the incorporation of both fixed and random variables within a statistical analysis, enabling efficient inferences and more information to be gained from the data. There have been many recent advances in mixed modelling, particularly regarding the software and applications. This third edition of Brown and Prescott’s groundbreaking text provides an update on the latest developments, and includes guidance on the use of current SAS techniques across a wide range of applications. Presents an overview of the theory and applications of mixed models in medical research, including the latest developments and new sections on incomplete block designs and the analysis of bilateral data. Easily accessible to practitioners in any area where mixed models are used, including medical statisticians and economists. Includes numerous examples using real data from medical and health research, and epidemiology, illustrated with SAS code and output. Features the new version of SAS, including new graphics for model diagnostics and the procedure PROC MCMC. Supported by a website featuring computer code, data sets, and further material. This third edition will appeal to applied statisticians working in medical research and the pharmaceutical industry, as well as teachers and students of statistics courses in mixed models. The book will also be of great value to a broad range of scientists, particularly those working in the medical and pharmaceutical areas.

Statistical Methods for Healthcare Performance Monitoring


Author: Alex Bottle,Paul Aylin
Publisher: CRC Press
ISBN: 1482246104
Category: Mathematics
Page: 269
View: 9029

Continue Reading →

Healthcare is important to everyone, yet large variations in its quality have been well documented both between and within many countries. With demand and expenditure rising, it’s more crucial than ever to know how well the healthcare system and all its components – from staff member to regional network – are performing. This requires data, which inevitably differ in form and quality. It also requires statistical methods, the output of which needs to be presented so that it can be understood by whoever needs it to make decisions. Statistical Methods for Healthcare Performance Monitoring covers measuring quality, types of data, risk adjustment, defining good and bad performance, statistical monitoring, presenting the results to different audiences and evaluating the monitoring system itself. Using examples from around the world, it brings all the issues and perspectives together in a largely non-technical way for clinicians, managers and methodologists. Statistical Methods for Healthcare Performance Monitoring is aimed at statisticians and researchers who need to know how to measure and compare performance, health service regulators, health service managers with responsibilities for monitoring performance, and quality improvement scientists, including those involved in clinical audits.

Statistical Methods for Survival Trial Design

With Applications to Cancer Clinical Trials Using R
Author: Jianrong Wu
Publisher: CRC Press
ISBN: 0429892934
Category: Mathematics
Page: 257
View: 9850

Continue Reading →

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint. Traditional cancer trial designs with time-to-event endpoints are often limited to the exponential model or proportional hazards model. In practice, however, those model assumptions may not be satisfied for long-term survival trials. This book is the first to cover comprehensively the many newly developed methodologies for survival trial design, including trial design under the Weibull survival models; extensions of the sample size calculations under the proportional hazard models; and trial design under mixture cure models, complex survival models, Cox regression models, and competing-risk models. A general sequential procedure based on the sequential conditional probability ratio test is also implemented for survival trial monitoring. All methodologies are presented with sufficient detail for interested researchers or graduate students.

Henry's Clinical Diagnosis and Management by Laboratory Methods E-Book


Author: Richard A. McPherson,Matthew R. Pincus
Publisher: Elsevier Health Sciences
ISBN: 1455726842
Category: Medical
Page: 1568
View: 7861

Continue Reading →

Recognized as the definitive book in laboratory medicine since 1908, Henry’s Clinical Diagnosis and Management by Laboratory Methods, edited by Richard A. McPherson, MD and Matthew R. Pincus, MD, PhD, is a comprehensive, multidisciplinary pathology reference that gives you state-of-the-art guidance on lab test selection and interpretation of results. Revisions throughout keep you current on the latest topics in the field, such as biochemical markers of bone metabolism, clinical enzymology, pharmacogenomics, and more! A user-friendly full-color layout puts all the latest, most essential knowledge at your fingertips. Update your understanding of the scientific foundation and clinical application of today's complete range of laboratory tests. Get optimal test results with guidance on error detection, correction, and prevention as well as cost-effective test selection. Reference the information you need quickly and easily thanks to a full-color layout, many new color illustrations and visual aids, and an organization by organ system. Master all the latest approaches in clinical laboratory medicine with new and updated coverage of: the chemical basis for analyte assays and common interferences; lipids and dyslipoproteinemia; markers in the blood for cardiac injury evaluation and related stroke disorders; coagulation testing for antiplatelet drugs such as aspirin and clopidogrel; biochemical markers of bone metabolism; clinical enzymology; hematology and transfusion medicine; medical microbiology; body fluid analysis; and many other rapidly evolving frontiers in the field. Effectively monitor the pace of drug clearing in patients undergoing pharmacogenomic treatments with a new chapter on this groundbreaking new area. Apply the latest best practices in clinical laboratory management with special chapters on organization, work flow, quality control, interpretation of results, informatics, financial management, and establishing a molecular diagnostics laboratory. Confidently prepare for the upcoming recertification exams for clinical pathologists set to begin in 2016.

Intravascular Infusion Systems

Principles and Practice
Author: R. Ausman
Publisher: Springer Science & Business Media
ISBN: 9401163413
Category: Medical
Page: 208
View: 9367

Continue Reading →

This book has been written for use by health professionals, typically physicians, nurses, and pharmacists, who have a constant relationship with intravascular infusions. It is intended to provide information where appropriate and guidance when possible for the safe and effective use of parenteral fluids. For several years medical practitioners viewed 'i.v. fluids' rather casu ally. In as much as the solutions themselves seemed innocuous, these medications did not enjoy the respect given to more potent pharmaceuti cals. Intravenous fluid systems were commodities; purchase and use decisions for whole hospitals were placed in the domain of business office personnel. Any tendency toward cessation of 'in hospital manufacture' of solutions was driven by the adverse economics of costly equipment replacement rather than a desire to improve the quality of the product being administered to the patient. An event in 1971 which changed this environment involved an epidemic of patient infections which were related to a specific solution system. Almost immediately there was an enhanced involvement of health care people who assumed responsibility for i.v. fluids and their use. This intensity of interest has not diminished. A few years ago publication of this book would not have been possible because there was no audience for it. No one was interested. Now there are many people who want to know and want to become involved. It is my hope those who read this book will not be disappointed.

Health Surveys and Related Studies


Author: M. Alderson,R. Dowie
Publisher: Elsevier
ISBN: 1483285502
Category: Social Science
Page: 356
View: 1754

Continue Reading →

This review describes the statistics of health care derived from non-routine sources. The chapter on need describes local and national population studies and general morbidity surveys as well as covering a range of specific problem studies. Statistics reflecting unmet demand are described as they relate to the various stages of medical care from primary medical to patient care. Resources are described in statistics of facilities as well as the various classes of manpower employed, and the uses of services chapter covers all community and hospital services. Studies which evaluate medical care are divided into those which reflect accessibility and acceptability as well as outcome of care and satisfaction of patients, families and staff. An introduction contains a discussion on the application of statistics and the concluding chapter looks towards a future unified health information system.

Understanding Nursing Research

Building an Evidence-Based Practice
Author: Susan K. Grove,Jennifer R. Gray,Nancy Burns
Publisher: Elsevier Health Sciences
ISBN: 0323293328
Category: Medical
Page: 544
View: 9697

Continue Reading →

As the bestselling nursing research text, Understanding Nursing Research: Building an Evidence-Based Practice, 6th Edition offers unique insights into understanding, appraising, and applying published research to evidence-based practice. It is known for its authoritative content, time-tested systematic approach, and unique research example format newly redesigned for the sixth edition to better demonstrate how the steps of the research process relate to evidence-based nursing. "This would be excellent for student nurses, nurses new to research or any nurse with an interest in research." Reviewed by: Helen Reeves, St Giles Walsall Hospice on behalf of Nursing Times, December 2015 Authoritative content is written by two of the true pioneers in nursing research, who offer unique, first-hand insights into the field. Research examples provide practice in working with published studies, with many of the examples including Critical Appraisal and Implications for Practice sections. Clear, step-by-step organization introduces the research process and demonstrates how this systematic framework relates to evidence-based practice. Strong emphasis on evidence-based practice helps you develop skills in studying and appraising published research, so you are prepared for your role in working with research evidence. Critical Appraisal Guidelines boxes provide step-by-step guidance in appraising published research studies. Emphasis on critical appraisal versus critique reflects contemporary usage in nursing research and evidence-based practice. Balanced coverage of qualitative research prepares you to approach research questions and clinical questions with an unbiased view of the researcher's methodology. Presentation of two different appraisal processes covers both the traditional in-depth critical appraisal process that prepares you for graduate-level work in research, and the concise, practice-focused research appraisal process that equips you for quick and accurate evaluation of the applicability of research findings to clinical practice. NEW! Redesigned research example format includes research examples have been thoroughly redesigned with a clear hierarchy of subcategories. NEW! Improved focus on need-to-know content and greater use of bulleting, creative illustrations, and tables, employs a more consistent, streamlined approach from chapter to chapter. NEW! Updated research examples ensure you are learning through the most clinically relevant topics and studies. NEW! Detailed directions on how to critically appraise research syntheses — such as systematic reviews, meta-analyses, meta-syntheses, and mixed-methods systematic reviews — increase your understanding of the types of research syntheses conducted in nursing and how to determine the quality of these syntheses and the relevance of their findings for practice. NEW! A unique emphasis on QSEN, aided by the input of a QSEN consultant, increases the book’s relevance to national curriculum standards and promotes the safe practice of nursing by using the most current research. NEW! Chapter on the Enhanced Literature Review provides guidelines for structure of reviews written for different purposes. NEW! More practically focused chapter on Outcomes Research better addresses the trending topic of outcomes research. NEW! Expanded coverage of mixed-methods research and translational research responds to the growing emphasis on these research emphases. NEW! Expanded coverage of cultural competency and cultural validity

BMJ

British Medical Journal
Author: N.A
Publisher: N.A
ISBN: N.A
Category: Medicine
Page: N.A
View: 3961

Continue Reading →

Clinical Pharmacology


Author: Morris J. Brown,Pankaj Sharma,Peter N. Bennett
Publisher: Elsevier Health Sciences
ISBN: 0702051136
Category: Medical
Page: 640
View: 9569

Continue Reading →

A thorough knowledge of pharmacological and therapeutic principles is vital if drugs are to be used safely and effectively for increasingly informed patients. Those who clearly understand how drugs get into the body, how they produce their effects, what happens to them in the body, and how evidence of their therapeutic effect is assessed, will choose drugs more skilfully, and use them more safely and successfully than those who do not. Now in a fully revised 11th edition, Clinical Pharmacology is essential reading for undergraduate medical students, junior doctors and anyone concerned with evidence-based drug therapy. Introductory first three sections cover general principle of clinical pharmacology; five subsequent sections cover drug treatment of disease organised by body system. Retains approachable style set by the original author, Professor Laurence. Emphasis throughout is on evidence-based and safe drug prescribing. Indian Advisory Board will ensure content reflects the needs of the devloping world.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics - E-Book


Author: Carl A. Burtis,Edward R. Ashwood,David E. Bruns
Publisher: Elsevier Health Sciences
ISBN: 1455759422
Category: Medical
Page: 2256
View: 8904

Continue Reading →

As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors, Ann Gronowski, W. Greg Miller, Michael Oellerich, Francois Rousseau, Mitchell Scott, and Karl Voelkerding, lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.

Low-level Radiation

Biological Interactions, Risks and Benefits : a Bibliography
Author: N.A
Publisher: N.A
ISBN: N.A
Category: Radiation
Page: 731
View: 3160

Continue Reading →

Principles and Practice of Hospital Medicine


Author: Sylvia McKean,Daniel Dressler,John Ross
Publisher: McGraw Hill Professional
ISBN: 0071603891
Category: Medical
Page: 2310
View: 6648

Continue Reading →

"Presented in full color and enhanced by more than 700 illustrations, this authoritative text provides a background in all the important clinical, organizational, and administrative areas now required for the practice of hospital medicine. The goal of the book is provide trainees, junior and senior clinicians, and other professionals with a comprehensive resource that they can use to improve care processes and performance in the hospitals that serve their communities. Each chapter opens with boxed Key Clinical Questions that are addressed in the text and hundreds of tables encapsulate important information. Case studies demonstrate how to apply the concepts covered in the text directly to the hospitalized patient."--amazon.com.

Secondary Analysis of Electronic Health Records


Author: MIT Critical Data
Publisher: Springer
ISBN: 3319437429
Category: Medical
Page: 427
View: 6150

Continue Reading →

This book trains the next generation of scientists representing different disciplines to leverage the data generated during routine patient care. It formulates a more complete lexicon of evidence-based recommendations and support shared, ethical decision making by doctors with their patients. Diagnostic and therapeutic technologies continue to evolve rapidly, and both individual practitioners and clinical teams face increasingly complex ethical decisions. Unfortunately, the current state of medical knowledge does not provide the guidance to make the majority of clinical decisions on the basis of evidence. The present research infrastructure is inefficient and frequently produces unreliable results that cannot be replicated. Even randomized controlled trials (RCTs), the traditional gold standards of the research reliability hierarchy, are not without limitations. They can be costly, labor intensive, and slow, and can return results that are seldom generalizable to every patient population. Furthermore, many pertinent but unresolved clinical and medical systems issues do not seem to have attracted the interest of the research enterprise, which has come to focus instead on cellular and molecular investigations and single-agent (e.g., a drug or device) effects. For clinicians, the end result is a bit of a “data desert” when it comes to making decisions. The new research infrastructure proposed in this book will help the medical profession to make ethically sound and well informed decisions for their patients.

The medical research directory


Author: John Wiley & Sons
Publisher: John Wiley & Sons
ISBN: 9780471103356
Category: Medical
Page: 730
View: 6038

Continue Reading →

British medical and nursing research currently being conducted in universities, polytechnics, colleges, government laboratories, hospitals, and elsewhere (excludes certain programs in commercial fields). Arranged under 45 subjects. Each entry gives institution, address, head of department, names of researchers, and subjects of research. Name and subject indexes

Advancing the Human Right to Health


Author: José M. Zuniga,Stephen P. Marks,Lawrence O. Gostin
Publisher: OUP Oxford
ISBN: 0191637645
Category: Medical
Page: 480
View: 3047

Continue Reading →

Advancing the Human Right to Health offers a prospective on the global response to one of the greatest moral, legal, and public health challenges of the 21st century - achieving the human right to health as enshrined in the Universal Declaration of Human Rights (UDHR) and other legal instruments. Featuring writings by global thought-leaders in the world of health human rights, the book brings clarity to many of the complex clinical, ethical, economic, legal, and socio-cultural questions raised by injury, disease, and deeper determinants of health, such as poverty. Much more than a primer on the right to health, this book features an examination of profound inequalities in health, which have resulted in millions of people condemned to unnecessary suffering and hastened deaths. In so doing, it provides a thoughtful account of the right to health's parameters, strategies on ways in which to achieve it, and discussion of why it is so essential in a 21st century context. Country-specific case studies provide context for analysing the right to health and assessing whether, and to what extent, this right has influenced critical decision-making that makes a difference in people's lives. Thematic chapters also look at the specific challenges involved in translating the right to health into action. Advancing the Human Right to Health highlights the urgency to build upon the progress made in securing the right to health for all, offering a timely reminder that all stakeholders must redouble their efforts to advance the human right to health.