Solid-Phase Extraction

Principles, Techniques, and Applications
Author: Nigel J.K. Simpson
Publisher: CRC Press
ISBN: 9781420056242
Category: Science
Page: 528
View: 7170

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Demonstrating the relationship of the basic theory of solid-phase extraction (SPE) to chromatography, this comprehensive reference illustrates how SPE techniques significantly contribute to the preparation of samples for a wide variety of analytical techniques. It provides step-by-step details on the applications of SPE to environmental matrices, broad-spectrum drug screening, veterinary drug abuse, pharmaceutical drug development, biological samples, and high-throughput screening. Written by world-renowned experts in the field, the book contains helpful reference charts, tables of solvent properties, selectivities, molecular acid/base properties, and more.

Solid-Phase Extraction

Principles and Practice
Author: E. M. Thurman,M. S. Mills
Publisher: Wiley-Interscience
ISBN: N.A
Category: Science
Page: 372
View: 8037

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Divided into three main parts, the book begins with a clear explanation of basic SPE conceptsincluding theory, chemistry, and mechanisms of interaction as well as methods development, troubleshooting, and optimization. The next section presents an in-depth look at SPE applications, with separate chapters devoted to clinical, environmental, and natural product chemistry. Numerous examples drawn from each of these three areas illustrate SPE in action in the real world, successfully bridging the gap between principles and practice. The final section of this book discusses the latest SPE technology, with detailed coverage of the automation process, solid-phase extraction disks, and innovations such as solid-phase microextraction and small-volume solid-phase extraction. Suggested reading and references are included throughout, providing a useful springboard for further research and study. Whether you are new to SPE or are looking to keep abreast of the newest developments in SPE methods and uses, Solid-Phase Extraction gives you instant access to the information you needan essential companion for chemists of all types who use SPE in their work. Complete coverage of SPE concepts and applicationsat your fingertips Solid-Phase Extraction (SPE) equips chemists in any field with an incomparable one-stop source of up-to-date information on SPE. With sections devoted to fundamental principles, applications, and new technology, it is both comprehensive and easy to use the ideal working reference on this important subject. Presents a straightforward examination of SPE theory, methods development, chemistry, and mechanisms of interaction Provides detailed coverage of SPE applications in clinical, environmental, and natural product chemistry Features practical examples illustrating a range of real-world SPE uses Prepares chemists to make informed decisions on sorbent selection Covers the latest SPE technology, with valuable insights on automation and new sample preparation methods Offers suggestions for further reading, Internet resources, and product guides

Solid-Phase Extraction

Principles and Practice
Author: E. M. Thurman,M. S. Mills
Publisher: Wiley-Interscience
ISBN: N.A
Category: Science
Page: 372
View: 1995

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Divided into three main parts, the book begins with a clear explanation of basic SPE conceptsincluding theory, chemistry, and mechanisms of interaction as well as methods development, troubleshooting, and optimization. The next section presents an in-depth look at SPE applications, with separate chapters devoted to clinical, environmental, and natural product chemistry. Numerous examples drawn from each of these three areas illustrate SPE in action in the real world, successfully bridging the gap between principles and practice. The final section of this book discusses the latest SPE technology, with detailed coverage of the automation process, solid-phase extraction disks, and innovations such as solid-phase microextraction and small-volume solid-phase extraction. Suggested reading and references are included throughout, providing a useful springboard for further research and study. Whether you are new to SPE or are looking to keep abreast of the newest developments in SPE methods and uses, Solid-Phase Extraction gives you instant access to the information you needan essential companion for chemists of all types who use SPE in their work. Complete coverage of SPE concepts and applicationsat your fingertips Solid-Phase Extraction (SPE) equips chemists in any field with an incomparable one-stop source of up-to-date information on SPE. With sections devoted to fundamental principles, applications, and new technology, it is both comprehensive and easy to use the ideal working reference on this important subject. Presents a straightforward examination of SPE theory, methods development, chemistry, and mechanisms of interaction Provides detailed coverage of SPE applications in clinical, environmental, and natural product chemistry Features practical examples illustrating a range of real-world SPE uses Prepares chemists to make informed decisions on sorbent selection Covers the latest SPE technology, with valuable insights on automation and new sample preparation methods Offers suggestions for further reading, Internet resources, and product guides

Chemical Analysis of Food: Techniques and Applications


Author: Yolanda Picó
Publisher: Academic Press
ISBN: 0123848636
Category: Science
Page: 812
View: 5874

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Chemical Analysis of Food: Techniques and Applications reviews new technology and challenges in food analysis from multiple perspectives: a review of novel technologies being used in food analysis, an in-depth analysis of several specific approaches, and an examination of the most innovative applications and future trends. This book won a 2012 PROSE Award Honorable Mention in Chemistry and Physics from the Association of American Publishers. The book is structured in two parts: the first describes the role of the latest developments in analytical and bio-analytical techniques and the second reviews the most innovative applications and issues in food analysis. Each chapter is written by experts on the subject and is extensively referenced in order to serve as an effective resource for more detailed information. The techniques discussed range from the non-invasive and non-destructive, such as infrared spectroscopy and ultrasound, to emerging areas such as nanotechnology, biosensors and electronic noses and tongues. Important tools for problem-solving in chemical and biological analysis are discussed in detail. Winner of a PROSE Award 2012, Book: Honorable Mention in Physical Sciences and Mathematics - Chemistry and Physics from the American Association of Publishers Provides researchers with a single source for up-to-date information in food analysis Single go-to reference for emerging techniques and technologies Over 20 renowned international contributors Broad coverage of many important techniques makes this reference useful for a range of food scientists

Sample Preparation Techniques in Analytical Chemistry


Author: Somenath Mitra
Publisher: John Wiley & Sons
ISBN: 9780471457824
Category: Science
Page: 488
View: 1595

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The importance of accurate sample preparation techniques cannot beoverstated--meticulous sample preparation is essential. Oftenoverlooked, it is the midway point where the analytes from thesample matrix are transformed so they are suitable for analysis.Even the best analytical techniques cannot rectify problemsgenerated by sloppy sample pretreatment. Devoted entirely to teaching and reinforcing these necessarypretreatment steps, Sample Preparation Techniques in AnalyticalChemistry addresses diverse aspects of this important measurementstep. These include: * State-of-the-art extraction techniques for organic and inorganicanalytes * Sample preparation in biological measurements * Sample pretreatment in microscopy * Surface enhancement as a sample preparation tool in Raman and IRspectroscopy * Sample concentration and clean-up methods * Quality control steps Designed to serve as a text in an undergraduate or graduate levelcurriculum, Sample Preparation Techniques in Analytical Chemistryalso provides an invaluable reference tool for analytical chemistsin the chemical, biological, pharmaceutical, environmental, andmaterials sciences.

Quantitative Dünnschichtchromatographie

Eine Anleitung für Praktiker
Author: Bernd Spangenberg
Publisher: Springer-Verlag
ISBN: 3642551025
Category: Science
Page: 462
View: 2886

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Die Dünnschichtchromatographie (DC) ist besonders in der pharmazeutischen Analytik und der Lebensmittelanalytik eine häufig durchgeführte Trenntechnik. Während es eine umfangreiche Literatur zum qualitativen Nachweis chemischer Substanzen mittels DC gibt, liegt der Fokus in diesem Buch bei der quantitativen Analyse.

Handbook of Isolation and Characterization of Impurities in Pharmaceuticals


Author: Satinder Ahuja,Karen Mills Alsante
Publisher: Academic Press
ISBN: 9780120449828
Category: Medical
Page: 414
View: 2750

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The United States Food and Drug Administration (FDA) and other regulatory bodies around the world require that impurities in drug substance and drug product levels recommended by the International Conference on Harmonisation (ICH) be isolated and characterized. Identifying process-related impurities and degradation products also helps us to understand the production of impurities and assists in defining degradation mechanisms. When this process is performed at an early stage, there is ample time to address various aspects of drug development to prevent or control the production of impurities and degradation products well before the regulatory filing and thus assure production of a high-quality drug product. This book, therefore, has been designed to meet the need for a reference text on the complex process of isolation and characterization of process-related (synthesis and formulation) impurities and degradation products to meet critical requlatory requirements. It's objective is to provide guidance on isolating and characterizing impurities of pharmaceuticals such as drug candidates, drug substances, and drug products. The book outlines impurity identification processes and will be a key resource document for impurity analysis, isolation/synthesis, and characterization. - Provides valuable information on isolation and characterization of impurities. - Gives a regulatory perspective on the subject. - Describes various considerations involved in meeting regulatory requirements. - Discusses various sources of impurities and degredation products.

Analytical Solid-Phase Extraction


Author: James S. Fritz
Publisher: Wiley-VCH
ISBN: 9780471246671
Category: Science
Page: 224
View: 3552

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New trends in solid-phase extraction for analytical use-a practical introduction. Owing to its low cost, ease of use, and nonpolluting means of preparing samples for analysis, solid-phase extraction (SPE) is fast overtaking traditional liquid-liquid methods in clinical, pharmaceutical, agricultural, and industrial applications. This book describes what analytical scientists and technicians need to know about this emerging procedure: how it works, how to choose from available techniques, how to utilize it effectively in the laboratory. Along with the historical perspective and fundamental principles, this practical book reviews the latest literature on solid-phase materials, equipment, and applications-including EPA-endorsed techniques. Special features include: * Coverage of separation and uptake methods. * Promising developments in the use of membrane disks. * The advantages of using polymeric resins over silica materials. * Mechanism and use of ion-exchange materials for SPE. * A remarkably complete chapter on the extraction of metal ions. * Groundbreaking research in the miniaturized SPE technique. Readers seeking additional information on SPE procedures may wish to consult: SOLID-PHASE EXTRACTION, Principles and Practice, E. M. Thurman and M. S. Mills 1998 (0-471-61422-X) 384 pp. SOLID-PHASE MICROEXTRACTION Theory and Practice Janusz Pawliszyn 1997 (0-471-19034-9) 264 pp.

Forensic and Clinical Applications of Solid Phase Extraction


Author: Michael J. Telepchak
Publisher: Springer Science & Business Media
ISBN: 1592592929
Category: Medical
Page: 370
View: 6148

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This complete laboratory reference manual explains the principles behind solid phase extraction (SPE) and provides readily reproducible protocols for solving extraction problems in forensic and clinical chemistry. Numerous actual chromatograms, based on original research and diverse applications, demonstrate the technique and the results that can be achieved. Extensive appendices allow fast access to frequently needed information on reagents, the preparation of solutions and buffers, milliequivalent and millimode calculations, buffers and pKa for SPE, and a complete RapidTrace® technical manual. Each proven protocol is described in step-by-step detail and contains an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and on avoiding known pitfalls.

Internal Reflection and ATR Spectroscopy


Author: Milan Milosevic
Publisher: John Wiley & Sons
ISBN: 0470278323
Category: Science
Page: 239
View: 7462

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Attenuated Total Reflection (ATR) Spectroscopy is now the most frequently used sampling technique for infrared spectroscopy. This book fully explains the theory and practice of this method. Offers introduction and history of ATR before discussing theoretical aspects Includes informative illustrations and theoretical calculations Discusses many advanced aspects of ATR, such as depth profiling or orientation studies, and particular features of reflectance

High Throughput Bioanalytical Sample Preparation

Methods and Automation Strategies
Author: David A. Wells
Publisher: Elsevier Science
ISBN: 9780444510297
Category: Science
Page: 610
View: 2844

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Several chapters introduce and discuss microplates, accessory products and automation devices. Particular strategies for efficient use of automation within a bioanalytical laboratory are also presented. The subject material then reviews protein precipitation, liquid-liquid extraction, solid-phase extraction and various on-line sample preparation approaches. The book concludes with information on recent advances in sample preparation, such as solid-phase extraction in a card format and higher density extraction plates. Important objectives that can be accomplished when the strategies presented in this book are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods; return on investment in automation for sample preparation; and improved knowledge and expertise of laboratory staff.-

Analytical Microextraction Techniques


Author: M. Valcárcel,S. Cárdenas,R. Lucena
Publisher: Bentham Science Publishers
ISBN: 1681083795
Category: Science
Page: 425
View: 1729

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Sample treatment has been the focus of intensive research in the last 20 years since it still remains a bottleneck in precise analytical procedures. The low concentration of the target analytes, the large amount of potential interfering agents and the incompatibility of the sample matrix with the instrumental techniques are the main reasons for these bottlenecks. In most of these methods, sample treatment is an unavoidable step and it has a clear influence on the quality (sensitivity, selectivity, and accuracy) of the final analytical results. While the usefulness of microextraction techniques has been established, their complete acceptance in analytical laboratories (including official methods of analysis) depends on their successful automation and integration with conventional analytical instrumentation. Analytical Microextraction Techniques presents comprehensive information about several analytical methods that are useful in the laboratory. These include: sorptive microextraction, solid and liquid phase microextraction, packed sorbent microextraction, miniaturized dispersive solid-phase extraction, thin film and nanoparticle based techniques, and membrane-based techniques. This is a vital reference on microextraction and sample preparation techniques for applied chemistry students, analytical chemists and laboratory technicians.

Chromatography

fundamentals and applications of chromatography and related differential migration methods
Author: Erich Heftmann
Publisher: Elsevier Science Ltd
ISBN: N.A
Category: Science
Page: 1156
View: 2108

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Chromatography has emerged as the most important and versatile analytical method. The book is not only an updated version of Heftmann's classical text, but it covers areas of future importance, such as microfluidics and computer resources. Under his experienced guidance, authorities in each field have contributed their practical experience to an integrated treatment of modern micro analysis. In Part A the theoretical basis of individual separation methods is explained and the technical aspects are illustrated. It includes the theory of gas and liquid chromatography as well as specific chromatographic techniques, such as size-exclusion, planar, ion, and affinity chromatography as well as various electrokinetic separation techniques. Microfluidics are covered fotr the first time and useful sources of analytical instruments are listed and evaluated. Part B brings the traditional field of application up to date. These include amino acids and proteins, nucleic acids and their constituents, lipid, and carbohydrates. Special chapters are devoted to the most important areas of application: drug and environmental analysis. Forensic and phytochemical applications are covered for the first time. Together with an overview of computer resources, the subject index allows novices as well as experts to obtain rapid and authoritative guidance to analytical problems, such as choice of methods and optimization of techniques and instrumentation.

Trace Environmental Quantitative Analysis

Principles, Techniques and Applications, Second Edition
Author: Paul R. Loconto
Publisher: CRC Press
ISBN: 1420030566
Category: Technology & Engineering
Page: 744
View: 2100

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Trace Environmental Quantitative Analysis: Principles, Techniques, and Applications, Second Edition offers clear and relevant explanations of the principles and practice of selected analytical instrumentation involved in trace environmental quantitative analysis (TEQA). The author updates each chapter to reflect the latest improvements in TEQA that have resulted in greater levels of sensitivity. The book begins with an overview of regulatory and EPA methods, followed by quantitative data reduction and interpretation of analytical results, sample preparation, and analytical instrumentation. Among the more than two-dozen new topics are the underlying principles of GC-MS, GC-MS-MS, LC-MS, and ICP-MS, column chromatographic cleanup, gel permeation chromatography, applications to biological sample matrices, and matrix solid-phase dispersion. The chapter on sample preparation now includes more alternatives to liquid-liquid extraction, highlighting Solid Phase Microextraction (SPME), and Stir Bar Sorptive Extraction (SBSE). The final chapter contains laboratory-tested experiments to practice the techniques appearing in the text. Appendices include a convenient glossary, applications to drinking water, computer programs for TEQA, instrument designs, and useful Internet links for practicing environmental analytical chemists. Featuring personal insight into the theory and practice of trace analysis from a bench analytical chemist, the second edition of Trace Environmental Quantitative Analysis takes readers from the fundamental principles to state-of-the-art methods of TEQA currently used in leading laboratories.

Compiler

Prinzipien, Techniken und Werkzeuge
Author: Alfred V. Aho
Publisher: Pearson Deutschland GmbH
ISBN: 9783827370976
Category: Compiler
Page: 1253
View: 9686

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Sampling and Sample Preparation for Field and Laboratory

Fundamentals and New Directions in Sample Preparation
Author: Janusz Pawliszyn
Publisher: Elsevier
ISBN: 9780444505118
Category: Science
Page: 1131
View: 2808

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This title is the first comprehensive book on sampling and modern sample preparation techniques and has several main objectives: to facilitate recognition of sample preparation as both an integral part of the analytical process; to present a fundamental basis and unified theoretical approach for the professional development of sample preparation; to emphasize new developments in sample preparation technology; and to highlight the future impact of sample preparation on new directions in analytical science, particularly automation, miniaturization and field implementation. Until recently, there has been relatively little scientific interest in sampling and sample preparation, however this situation is presently changing as sampling and sample preparation become integral parts of the analytical process with their own unique challenges and research opportunities. Sampling and Sample Preparation for Field and Laboratory is an essential resource for all analytical chemists, and in particular those involved in method development. Not only does it cover the fundamental aspects of extraction, it also covers applications in various matrices and includes sampling strategies and equipment and how these can be integrated into the analytical process for maximum efficiency.

Essentials of Botanical Extraction

Principles and Applications
Author: Subhash C. Mandal,Vivekananda Mandal,Anup Kumar Das
Publisher: Academic Press
ISBN: 0128025638
Category: Science
Page: 220
View: 4005

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Essentials of Botanical Extraction: Principles and Applications provides a unique, single source of valuable information on the various botanical extraction methods available, from conventional to the use of green and modern extraction technologies including ultrasounds, microwaves, pressurized liquids, and supercritical fluids. Most extracts obtained from botanicals are often poorly characterized with unidentified active or inactive constituents. A wise selection of an extraction strategy is vital to drug discovery from medicinal plants as extraction forms the basic first step in medicinal plant research. This book also explores the mathematical hypotheses and innovations in botanical extractions and analyzes different post extraction operations so that dependency on serendipity is reduced and the same be converted into programmed drug discovery. Reviews the history and current state of natural product drug discovery and development, highlighting successes and current issues Explains the application of chemometric tools in extraction process design and method development Introduces process intensification as applied to the processing of medicinal plant extracts for rapid and cost-effective extraction

Residue Analysis in Food

Principles and Applications
Author: Michael O'Keefe
Publisher: CRC Press
ISBN: 9789057024412
Category: Technology & Engineering
Page: 324
View: 3991

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Residue analysis in food is an essential science in terms of the number of laboratories and analysts involved worldwide and the range of analytical techniques available. This text uniquely combines the principles and applications of the various techniques employed in residue analysis, so as to provide the reader with a thorough understanding and practical demonstration of the science of residue analysis in food. The various techniques employed in residue analysis are described in detail in this book. Each chapter deals with the principles underlying the techniques and illustrates practical applications of the technique through examples from the scientific literature. Written by established scientists working in the areas of technique development and application to residue analysis, the text describes the sequence of the analytical procedure, from sample treatment through to residue determination. Of interest to all scientists in the field of residue analysis and food safety, this text is an essential reference for practising residue analysts and researchers.

Environmental Chemistry for a Sustainable World

Volume 2: Remediation of Air and Water Pollution
Author: Eric Lichtfouse,Jan Schwarzbauer,Didier Robert
Publisher: Springer Science & Business Media
ISBN: 9789400724396
Category: Science
Page: 541
View: 2256

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Environmental chemistry is a fast developing science aimed at deciphering fundamental mechanisms ruling the behaviour of pollutants in ecosystems. Applying this knowledge to current environmental issues leads to the remediation of environmental media, and to new, low energy, low emission, sustainable processes. Chapters review analysis and remediation of pollutants such as greenhouse gases, chiral pharmaceuticals, dyes, chlorinated organics, arsenic, toxic metals and pathogen in air, water, plant and soil. Several highlights include the overlooked impact of air pollutants from buildings for health risk, innovative remediation techniques such as bioreactors for gas treatment, electrochemical cleaning of pharmaceuticals, sequestration on Fe-Mn nodules, phytoremediation and photocatalytical inactivation of microbial pathogens. This book will be a valuable source of information for engineers and students developing novel applied techniques to monitor and clean pollutants in air, wastewater, soils and sediments.