Regenesis

How Synthetic Biology Will Reinvent Nature and Ourselves
Author: George M. Church,Ed Regis
Publisher: Basic Books
ISBN: 0465038654
Category: Science
Page: 304
View: 2002

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“Bold and provocative… Regenesis tells of recent advances that may soon yield endless supplies of renewable energy, increased longevity and the return of long-extinct species.”—New Scientist In Regenesis, Harvard biologist George Church and science writer Ed Regis explore the possibilities—and perils—of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies—far from the out-of-control nightmare depicted in science fiction—have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

Regenesis

How Synthetic Biology Will Reinvent Nature and Ourselves
Author: George M. Church,Ed Regis
Publisher: Hachette UK
ISBN: 0465038654
Category: Science
Page: 304
View: 3872

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“Bold and provocative… Regenesis tells of recent advances that may soon yield endless supplies of renewable energy, increased longevity and the return of long-extinct species.”—New Scientist In Regenesis, Harvard biologist George Church and science writer Ed Regis explore the possibilities—and perils—of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies—far from the out-of-control nightmare depicted in science fiction—have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

Life at the Speed of Light

From the Double Helix to the Dawn of Digital Life
Author: J. Craig Venter
Publisher: Penguin
ISBN: 0143125907
Category: Science
Page: 224
View: 2555

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The author of A Life Decoded explains how his team's achievement with sequencing the human genome has launched an important age of biological research, revealing a growing potential for enabling humans to adapt and evolve for long-term survival and environmental improvement.

Synthetic Biology and Morality

Artificial Life and the Bounds of Nature
Author: Gregory E. Kaebnick,Thomas H. Murray
Publisher: MIT Press
ISBN: 0262519593
Category: Philosophy
Page: 214
View: 4801

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A range of views on the morality of synthetic biology and its place in public policy and political discourse.

What is Life?

Investigating the Nature of Life in the Age of Synthetic Biology
Author: Edward Regis
Publisher: Oxford University Press, USA
ISBN: 0195383419
Category: Science
Page: 198
View: 5178

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Erwin Schrödinger's 1944 classic What Is Life? is a small book that occupies a large place among the great written works of the twentieth century. It is said that it helped launch the modern revolution in biology and genetics, and inspired a generation of scientists, including Watson and Crick, to explore the riddle of life itself. Now, more than sixty years later, science writer Ed Regis offers an intriguing look at where this quest stands today. Regis ranges widely here, illuminating many diverse efforts to solve one of science's great mysteries. He examines the genesis of Schrödinger's great book--which first debuted as three public lectures in Dublin--and details the fantastic reception his ideas received, both in Europe and America. Regis also introduces us to the work of a remarkable group of scientists who are attempting literally to create life from scratch, starting with molecular components that they hope to assemble into the world's first synthetic living cell. The book also examines how scientists have unlocked the "three secrets of life," describes the key role played by ATP ("the ultimate driving force of all life"), and outlines the many attempts to explain how life first arose on earth, a puzzle that has given birth to a wide range of theories (which Francis Crick dismissed as "too much speculation running after too few facts"), from the primordial sandwich theory, to the theory that life arose in clay, in deep-sea vents, or in oily bubbles at the seashore, right up to Freeman Dyson's "theory of double origins." Written in a lively and accessible style, and bringing together a wide range of cutting-edge research, What is Life? makes an illuminating contribution to this ancient and ever-fascinating debate.

Synthetic

How Life Got Made
Author: Sophia Roosth
Publisher: University of Chicago Press
ISBN: 022644046X
Category: Science
Page: 256
View: 2153

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In the final years of the twentieth century, emigres from mechanical and electrical engineering and computer science resolved that if the aim of biology was to understand life, then making life would yield better theories than experimentation. Sophia Roosth, a cultural anthropologist, takes us into the world of these self-named synthetic biologists who, she shows, advocate not experiment but manufacture, not reduction but construction, not analysis but synthesis. Roosth reveals how synthetic biologists make new living things in order to understand better how life works. What we see through her careful questioning is that the biological features, theories, and limits they fasten upon are determined circularly by their own experimental tactics. This is a story of broad interest, because the active, interested making of the synthetic biologists is endemic to the sciences of our time."

Synthetic Biology

A Lab Manual
Author: Josefine Liljeruhm,Erik Gullberg,Anthony C Forster
Publisher: World Scientific
ISBN: 9814579564
Category: Science
Page: 204
View: 8739

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Synthetic Biology: A Lab Manual is the first manual for laboratory work in the new and rapidly expanding field of synthetic biology. Aimed at non-specialists, it details protocols central to synthetic biology in both education and research. In addition, it provides all the information that teachers and students from high schools and tertiary institutions need for a colorful lab course in bacterial synthetic biology using chromoproteins and designer antisense RNAs. As a bonus, practical material is provided for students of the annual international Genetically Engineered Machine (iGEM) competition. The manual is based upon a highly successful course at Sweden's Uppsala University and is coauthored by one of the pioneers of synthetic biology and two bioengineering postgraduate students. An inspiring foreword is written by another pioneer in the field, Harvard's George Church: “Synthetic biology is to early recombinant DNA as a genome is to a gene. Is there anything that SynBio will not impact? There was no doubt that the field of SynBio needed ‘A Lab Manual’ such as the one that you now hold in your hands.” Read about the interview with the authors! Contents:Introduction:What is Synthetic Biology, Exactly?The iGEM OutbreakA Synthetic Biology Lab ManualGenes, Chromoproteins and Antisense RNAs:E. coli DNA: Chromosomes, Plasmids and Copy NumberCoupling of Transcription and Translation in BacteriaPromoter and Terminator for TranscriptionRibosome Binding Site (RBS)Codon BiasChromoproteinsSmall Regulatory RNAs (sRNAs)Lab Rooms and Equipment:The Physical Lab SpacesEquipmentSafety is Priority #1:FiresChemicalsBiological Safety and DisposalDangerous EquipmentLab Course Projects:Time and ResourcesProject Overview and Learning ObjectivesThe Lab NotebookLab Section 1. Preparation of Chemical Solutions and Agar PlatesLab Section 2. Coloring Bacteria by Adding a Promoter to a Chromoprotein GeneLab Section 3: Rational Engineering of Chromoprotein Expression LevelLab Section 4. Other ExperimentsThe “Dreaded” ExamProtocols:IntroductionProtocol 1. Preparation of Solutions and Agar PlatesProtocol 2. Overnight Cultures with Antibiotics, and Glycerol StocksProtocol 3. BioBrick™ 3A Assembly and Gel AnalysisProtocol 4. Agarose Gel ElectrophoresisProtocol 5. Preparation of Competent E. coli Cells Using CaCl2Protocol 6. Transformation of CaCl2-Competent E. coli CellsProtocol 7. Bacterial Re-Streaking TechniquesProtocol 8. Lysis of E. coli Cells with LysozymeProtocol 9. Polymerase Chain Reaction (PCR)Protocol 10. Inverse PCR MutagenesisProtocol 11. Colony PCRProtocol 12. Gibson AssemblyAdvanced Methods:Flow Cytometry and Cell SortingRecombination in Plasmids and the ChromosomeElectrocompetent CellsThe International Genetically Engineered Machine (iGEM) Competition:How to Start an iGEM TeamUppsala iGEM 2011 — Show Color with ColorUppsala iGEM 2012 — Resistance is FutileUppsala iGEM 2013 — Lactonutritious — It's DeliciousAppendices Readership: Students and researchers in biotechnology, cell/molecular biology and genetics. Keywords:Synthetic Biology;Genetic Engineering;DNA Cloning;Polymerase Chain Reaction;Molecular Biology;Laboratory;Biobrick;Chromoprotein;Manual;CourseReviews: It provides an introductory workflow for common techniques and would be of definite use to educators wanting to bring synthetic biology into the classroom or for motivated undergraduate students with the desire to start thir own iGEM team.” Synthetic Biology See Full Review

Synthetic Aesthetics

Investigating Synthetic Biology's Designs on Nature
Author: Alexandra Daisy Ginsberg,Jane Calvert,Pablo Schyfter,Alistair Elfick,Drew Endy
Publisher: MIT Press
ISBN: 026201999X
Category: Medical
Page: 376
View: 804

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As synthetic biology transforms living matter into a medium for making, what is the role of design and its associated values?

Biopunk

Solving Biotech's Biggest Problems in Kitchens and Garages
Author: Marcus Wohlsen
Publisher: N.A
ISBN: 1617230073
Category: Science
Page: 250
View: 5471

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Examines the growing community of scientists working outside of the traditional corporate and academic environments to make biotechnology tools broadly available in order to fuel an explosion of innovation in genetic modification.

BioBuilder

Synthetic Biology in the Lab
Author: Natalie Kuldell PhD.,Rachel Bernstein,Karen Ingram,Kathryn M Hart
Publisher: "O'Reilly Media, Inc."
ISBN: 1491907533
Category: Science
Page: 238
View: 1675

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Today’s synthetic biologists are in the early stages of engineering living cells to help treat diseases, sense toxic compounds in the environment, and produce valuable drugs. With this manual, you can be part of it. Based on the BioBuilder curriculum, this valuable book provides open-access, modular, hands-on lessons in synthetic biology for secondary and post-secondary classrooms and laboratories. It also serves as an introduction to the field for science and engineering enthusiasts. Developed at MIT in collaboration with award-winning high school teachers, BioBuilder teaches the foundational ideas of the emerging synthetic biology field, as well as key aspects of biological engineering that researchers are exploring in labs throughout the world. These lessons will empower teachers and students to explore and be part of solving persistent real-world challenges. Learn the fundamentals of biodesign and DNA engineering Explore important ethical issues raised by examples of synthetic biology Investigate the BioBuilder labs that probe the design-build-test cycle Test synthetic living systems designed and built by engineers Measure several variants of an enzyme-generating genetic circuit Model "bacterial photography" that changes a strain’s light sensitivity Build living systems to produce purple or green pigment Optimize baker’s yeast to produce ?-carotene

Biology Is Technology


Author: Robert H. Carlson
Publisher: Harvard University Press
ISBN: 0674053621
Category: Science
Page: 288
View: 5493

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In Biology Is Technology, author Robert Carlson offers a uniquely informed perspective on the endeavors that contribute to current progress in the science of biological systems and the technology used to manipulate them.

The Ones


Author: Daniel Sweren-Becker
Publisher: Imprint
ISBN: 125008315X
Category: Young Adult Fiction
Page: 320
View: 7029

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We are not all created equal. Seventeen-year-old Cody and her boyfriend, James, were two of the lucky ones randomly selected before birth to receive genetic engineering. Known as the Ones, this one percent of the population is healthy, beautiful, and talented...and to some that's not fair. Mounting fear and jealousy of the Ones’ success leads to the creation of the Equality Movement, which quickly gains enough political traction to demote Cody, James, and others like them to second-class citizens. Cody knows even before the brick smashes through her window that it's going to be bad. As their school, the American government, and even family and friends turn against them, Cody begins to believe they have no other choice but to protect their own. She draws closer to a group of radical Ones led by the passionate and fevered Kai, and James begins to question just how far she is willing to go for the cause... Themes of justice, discrimination and terrorism mix with actual science to create a frightening version of our near future in Daniel Sweren-Becker's pulse-pounding thriller. An Imprint Book

Synthetic Biology — A Primer

Revised Edition
Author: N.A
Publisher: World Scientific
ISBN: 1783268816
Category: Science
Page: 196
View: 2859

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Synthetic Biology — A Primer (Revised Edition) presents an updated overview of the field of synthetic biology and the foundational concepts on which it is built. This revised edition includes new literature references, working and updated URL links, plus some new figures and text where progress in the field has been made. The book introduces readers to fundamental concepts in molecular biology and engineering and then explores the two major themes for synthetic biology, namely 'bottom-up' and 'top-down' engineering approaches. 'Top-down' engineering uses a conceptual framework of systematic design and engineering principles focused around the Design-Build-Test cycle and mathematical modelling. The 'bottom-up' approach involves the design and building of synthetic protocells using basic chemical and biochemical building blocks from scratch exploring the fundamental basis of living systems. Examples of cutting-edge applications designed using synthetic biology principles are presented, including: the production of novel, microbial synthesis of pharmaceuticals and fine chemicalsthe design and implementation of biosensors to detect infections and environmental waste. The book also describes the Internationally Genetically Engineered Machine (iGEM) competition, which brings together students and young researchers from around the world to carry out summer projects in synthetic biology. Finally, the primer includes a chapter on the ethical, legal and societal issues surrounding synthetic biology, illustrating the integration of social sciences into synthetic biology research. Final year undergraduates, postgraduates and established researchers interested in learning about the interdisciplinary field of synthetic biology will benefit from this up-to-date primer on synthetic biology. Contents:List of ContributorsPrefaceIntroduction to BiologyBasic Concepts in Engineering BiologyFoundational TechnologiesMinimal Cells and Synthetic LifeParts, Devices and SystemsModelling Synthetic Biology SystemsApplications of Designed Biological SystemsiGEMThe Societal Impact of Synthetic BiologyAppendices:Proforma of Common Laboratory TechniquesGlossaryIndex Readership: Students, professionals, researchers in biotechnology and bioengineering. Keywords:Synthetic Biology;Engineering Principles;Biosociety;Biological Engineering;BiotechnologyKey Features:The book is written in a way that is accessible to students and researchers from different disciplinesThe authors are part of the internationally recognised Centre for Synthetic Biology and Innovation and are among the leaders in this field

Synthetic Biology

Safety, Security, and Promise
Author: Gigi Gronvall
Publisher: Createspace Independent Publishing Platform
ISBN: 9781539336839
Category:
Page: 198
View: 6506

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Synthetic biology aims to make biology easier to engineer and to program. Thanks to advances in computing power, the ability to make long tracts of DNA, new tools like CRISPR that can be used to edit genomes, and the enthusiasm of young scientists and even amateurs who want to enter the field, synthetic biology is poised to change the future of medicine, agriculture, and manufacturing. Yet, while this new field promises vast opportunities and benefits, there are also risks. There are biosecurity risks that these technologies will be deliberately used for harm; safety risks to people and the environment; ethical and social considerations for how to apply these technologies; and there are risks to the competitiveness of nations that do not invest in these technologies that are likely to spur economic growth. This volume is dedicated to a discussion of what can be done to minimize risks and maximize the benefits of synthetic biology. Praise for Synthetic Biology: Safety, Security, and Promise "There can be no doubt that advances in the life sciences, including new insights and tools provided by synthetic biology, place us in a position to create exciting and novel products and approaches for patients in need. Gigi Gronvall describes that promise but also lays forth critical policy concerns that need to be addressed so that we don't risk safety, security, or the competitiveness of US science." - Margaret Hamburg, MD, Former FDA Commissioner and Foreign Secretary, National Academy of Medicine "Synthetic biology gives us tools that can help tackle global problems that affect humanity-but for that to happen, the risks of bioterror or bio-error need to be dealt with and managed, as well. Gronvall clearly describes the policy challenges that must be addressed and concludes with steps to enhance US leadership and competitiveness in the global bio-economy." - J. Craig Venter, PhD, founder, chairman, and CEO of the J. Craig Venter Institute and co-founder, executive chairman and co-chief scientist of Synthetic Genomics, Inc. "For those of us working in the lab, it is important to embrace conversations with those who aren't - including strategies for biological security, to create new synthetic biology products - with respect for facts about GMO risk/benefit balances, creating a culture of safe lab practices and norms worldwide. Gigi Gronvall dissects such issues at stake in synthetic biology and presents a pragmatic and scientifically responsive path forward for anyone in a position to influence, regulate, decide upon, or benefit from the science to follow." - George Church, PhD, Professor of Genetics Harvard Medical School and Director of PersonalGenomes.org "Synthetic biology presents some of the greatest challenges and opportunities of the 21st Century. Gigi Gronvall navigates a path to follow, to make sure risks are addressed and opportunities are not squandered. It should be read by all concerned about national security." - The Honorable Andrew Weber, head of global partnerships for Metabiota and former Assistant Secretary of Defense for Nuclear, Chemical, and Biological Defense Programs

Evolving Ourselves

Redesigning the Future of Humanity - One Gene at a Time
Author: Juan Enriquez,Steve Gullans
Publisher: Penguin
ISBN: 0143108344
Category: Science
Page: 384
View: 8923

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"Futurist Juan Enriquez and scientist Steve Gullans conduct a sweeping tour of how humans are changing the course of evolution for all species--sometimes intentionally, sometimes not. For example: What if life forms are limited only by the bounds of our imagination? Are designer babies and pets, de-extinction, even entirely newspecies fair game?; As humans, animals, and plants become ever more resistant to disease and aging, what will become the leading causes of death?; Man-machine interfaces may allow humans to live much longer. What will happen when we transfer parts of our 'selves' into clones, into stored cells and machines? Though these harbingers of change are deeply unsettling, the authors argue we are also in an epoch of tremendous opportunity. Future humans, perhaps a more diverse, resilient, gentler, and intelligent species, may become better caretakers of the planet--but only if we make the right choices now."--Provided by publisher.

The Equals


Author: Daniel Sweren-Becker
Publisher: Imprint
ISBN: 1250083176
Category: Young Adult Fiction
Page: 320
View: 943

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What happens when your own government turns against you? The Equality Team continues to round up and subject The Ones—the 1% of the American population who were genetically engineered in vitro—to a vaccine that will level the playing field. Desperate to save her boyfriend James from this fate, Cody flees into the wild to seek assistance from a shadowy rebel group dedicated to equal rights for the Ones at any cost. But when she grows closer to a radical named Kai, she's brought deeper into the fold, only to realize the group's leader has a secret plan more dangerous than Cody could have imagined—something that could change the course of the Ones' future. In The Equals, themes of justice, discrimination and terrorism mix with actual science to create a frightening version of our near future in Daniel Sweren-Becker's action-packed sequel to The Ones. An Imprint Book Praise for The Ones: "Chilling and frighteningly real, The Ones leads us down a dark rabbit hole of scientific possibilities, fractured morality, and brutal consequences. It forces the question: If perfection becomes a liability, how far are we willing to go in the pursuit of it -- or to stop it?"—Kami Garcia, #1 New York Times bestselling coauthor of Beautiful Creatures and author ofThe Lovely Reckless "Like watching your favorite TV show, The Ones is a thrill ride with a new shock at every turn. You won't believe what happens next, and yet, you should. Because this reality is all too possible." —Melissa de la Cruz, #1 New York Times bestselling author of Isle of the Lost and the forthcoming Something In Between “A gripping and cautionary tale. A thrilling read.” —Brendan Reichs, New York Times-bestselling coauthor of the Virals series. "The basic premise for this captivating tale is much closer to practical concern than many might imagine. It is crucial that we visualize many possible scenarios like this one so that we can humanely respond to (or better yet anticipate) new technologies and the consequences for new babies. We hopefully will not punish the latter for the shortcomings of the former, and books like this will help us all engage with the key issues, technical and moral." —George Church, Professor of Genetics at Harvard Medical School and author of Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves

Rise of the Necrofauna

The Science, Ethics, and Risks of De-extinction
Author: Britt Wray,George McDonald Church
Publisher: N.A
ISBN: 9781771641647
Category: PHILOSOPHY
Page: 293
View: 8740

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A provocative look at the controversial new science of de-extinction and the ethical questions it raises.

Creation

How Science Is Reinventing Life Itself
Author: Adam Rutherford
Publisher: Penguin
ISBN: 1101622628
Category: Science
Page: 288
View: 5634

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What is life? Humans have been asking this question for thou­sands of years. But as technology has advanced and our understanding of biology has deepened, the answer has evolved. For decades, scientists have been exploring the limits of nature by modifying and manipulating DNA, cells and whole organisms to create new ones that could never have existed on their own. In Creation, science writer Adam Rutherford explains how we are now radically exceeding the boundaries of evolution and engineering entirely novel creatures—from goats that produce spider silk in their milk to bacteria that excrete diesel to genetic circuits that identify and destroy cancer cells. As strange as some of these creations may sound, this new, synthetic biology is helping scientists develop radical solutions to some of the world’s most pressing crises—from food shortages to pandemic disease to climate change—and is paving the way for inventions once relegated to science fiction. Meanwhile, these advances are shedding new light on the biggest mystery of all—how did life begin? We know that every creature on Earth came from a single cell, sparked into existence four billion years ago. And as we come closer and closer to understanding the ancient root that connects all living things, we may finally be able to achieve a second genesis—the creation of new life where none existed before. Creation takes us on a journey four billion years in the making—from the very first cell to the ground-breaking biological inventions that will shape the future of our planet.

The Phantom of the Earth


Author: Raeden Zen
Publisher: Lulu Press, Inc
ISBN: 136584238X
Category: Fiction
Page: N.A
View: 7203

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Herbert's DUNE meets Banks' THE PLAYER OF GAMES in THE PHANTOM OF THE EARTH, a spellbinding science fiction epic set deep underground after the fall of civilization on Earth's surface. Here are the five thought-provoking postapocalyptic stories that lovers of science fiction can't stop talking about, gathered together in one volume for the first time. At the center of the conflict lie the Selendias of Piscator, founders of the resistance with an uncanny connection to the zeropoint field; and the Barão Strike Team, three researchers tasked with finding a cure to the Reassortment Strain, the plague that nearly wiped humanity from the Earth. Traveling from the uninhabitable but pristine surface to the habitable but inhospitable underground, this is a story about dedication to dreams, battle for survival, discovery and connection, song and celebration, undoing past misdeeds, and sacrifice for the greater good.

The Synthetic Age

Outdesigning Evolution, Resurrecting Species, and Reengineering Our World
Author: Christopher J. Preston
Publisher: Mit Press
ISBN: 9780262037617
Category: Nature
Page: 224
View: 3017

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Imagining a future in which humans fundamentally reshape the natural world using nanotechnology, synthetic biology, de-extinction, and climate engineering. We have all heard that there are no longer any places left on Earth untouched by humans. The significance of this goes beyond statistics documenting melting glaciers and shrinking species counts. It signals a new geological epoch. In The Synthetic Age, Christopher Preston argues that what is most startling about this coming epoch is not only how much impact humans have had but, more important, how much deliberate shaping they will start to do. Emerging technologies promise to give us the power to take over some of Nature's most basic operations. It is not just that we are exiting the Holocene and entering the Anthropocene; it is that we are leaving behind the time in which planetary change is just the unintended consequence of unbridled industrialism. A world designed by engineers and technicians means the birth of the planet's first Synthetic Age. Preston describes a range of technologies that will reconfigure Earth's very metabolism: nanotechnologies that can restructure natural forms of matter; "molecular manufacturing" that offers unlimited repurposing; synthetic biology's potential to build, not just read, a genome; "biological mini-machines" that can outdesign evolution; the relocation and resurrection of species; and climate engineering attempts to manage solar radiation by synthesizing a volcanic haze, cool surface temperatures by increasing the brightness of clouds, and remove carbon from the atmosphere with artificial trees that capture carbon from the breeze. What does it mean when humans shift from being caretakers of the Earth to being shapers of it? And in whom should we trust to decide the contours of our synthetic future? These questions are too important to be left to the engineers.