Natural Products Targeting Clinically Relevant Enzymes


Author: Paula B. Andrade,Patrícia Valentão,David M. Pereira
Publisher: John Wiley & Sons
ISBN: 3527805915
Category: Medical
Page: 250
View: 9447

Continue Reading →

The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.

Bioactive Natural Products

Detection, Isolation, and Structural Determination, Second Edition
Author: Steven M. Colegate,Russell J. Molyneux
Publisher: CRC Press
ISBN: 9781420006889
Category: Science
Page: 624
View: 5772

Continue Reading →

Bioactive natural products are proving to be a rich source of novel therapeutics to both protect against and combat diseases, as well as serve as lead compounds in crop protection. Following the successful format of the first edition, this volume brings together collective research from many new contributors and emphasizes the rationale behind the successful detection, isolation, and structure determination of specific compounds. The text encompasses a diverse range of techniques that can be applied to terrestrial and aquatic sources. It also allows you to understand how source material can be selected to enhance your opportunity to discover and utilize novel bioactive natural products. New to the Second Edition— · Advances in the application of NMR spectroscopy and mass spectrometry, bioactive chemical detection and extraction, dereplication, and novel bioassay development · New case studies and illustrations that demonstrate the practical applications of specific techniques · A group of new contributors presenting research from their own laboratories that emphasize both the philosophy and rationale behind detection, isolation, and structural determination Following an overview of natural product chemistry techniques and approaches, many new chapters discuss selection of source material, quantitative NMR, high speed counter-current chromatography, dereplication of extracts, and methods to determine the stereochemistry of bioactive natural products. Examinations of new technologies including LC-NMR, biosensors, and biofingerprinting accompany discussions on the search for specific activities in anticancer and antimalarial applications, seed germination stimulation, and mammalian toxicity. With the participation from active researchers, this definitive work supplies a vital extension and an enduring contribution to the science and art of bioactive natural product detection, isolation, and structural determination.

Gentechnologie für Einsteiger


Author: Terence A. Brown
Publisher: Springer
ISBN: 9783827413024
Category:
Page: 409
View: 7411

Continue Reading →

T. A. Browns "Gentechnologie fA1/4r Einsteiger" hat sich in mehreren Auflagen international als StandardeinfA1/4hrung in die Genklonierung und DNA-Analyse etabliert. Das Grundlagenlehrbuch setzt nur wenig Kenntnisse in Molekularbiologie und Genetik voraus und erlAutert in klarer Sprache sowohl die fundamentalen Prinzipien der wichtigsten gentechnologischen Methoden als auch die immer breiter werdende Palette ihrer Anwendungen. Die groAe Bedeutung der Gentechnologie fA1/4r die Grundlagenforschung und fA1/4r neue Entwicklungen in Biotechnologie und Medizin wird klar herausgearbeitet. Aoeber 250 zweifarbige Illustrationen erleichtern das VerstAndnis des Stoffes und machen die Konzepte und Arbeitstechniken der Gentechnologen anschaulich. Die neue Auflage ist vollstAndig A1/4berarbeitet und enthAlt zwei neue Kapitel. Eines prAsentiert die Methoden, mit denen man ganze Genome sequenziert, und beschreibt, was man aus den gewonnenen Sequenzinformationen ablesen kann. Das zweite widmet sich den Anwendungen der Gentechnologie in der Gerichtsmedizin - ein spannendes und aufschlussreiches Beispiel des Einsatzpotenzials der DNA-Analyse. Der groAen Bedeutung der Polymerasekettenreaktion (PCR) entsprechend wird diese Technik jetzt in einem frA1/4hen Abschnitt des Buches behandelt und durchgehend stArker berA1/4cksichtigt.

Comprehensive Natural Products Chemistry: DNA and aspects of molecular biology


Author: Sir Derek Barton,Kōji Nakanishi,Eric T. Kool,Otto Meth-Cohn
Publisher: Pergamon Press
ISBN: 9780080431598
Category: Science
Page: 733
View: 3818

Continue Reading →

Hardbound. This volume is intended to cover the chemistry of one of the most widely studied and important natural products, DNA. Discussed in detail are physicochemical properties of the molecule itself as well as small-molecule natural products that are known to interact with it. Also included are methods to synthesize and manipulate DNA and modified analogues. Twenty chapters are devoted to this overall topic.The first five relate to the structure of DNA; the first focuses on thermodynamics and kinetics of double helix formation; the next two describe triple- and tetra- helical structures formed by DNA; and the last two focus on methods for probing DNA structure (specifically, NMR methods and chemical probing methods, respectively).Chapters 6-12 focus on the chemistry of natural DNA and modified analogues. The first of these addresses nonenzymatic methods for synthesizing DNA, and the next chapter, on methods for attachment of reporter groups t

Drug Discovery from Natural Products


Author: Olga Genilloud,Francisca Vicente
Publisher: Royal Society of Chemistry
ISBN: 184973495X
Category: Medical
Page: 432
View: 1563

Continue Reading →

This book offers an integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology as a starting point in novel drug development. The authors focus on different trends that are and will continue to be impacting multiples stages of modern drug discovery from NPs that have not been included in other works. This is complemented with a series of case studies from leading experts from industry and academia on key molecules and derivatives that have been chosen for their novelty in chemistry, biology and clinical applications. The book intends to reflect the current confluence of different disciplines in chemical biology and synthetic chemistry supported by a more profound knowledge of systems biology that ensures the concurrency and synergisms of expertise from different research fields that impact in the discovery of novel molecules. In the first section the chapters reflect recent approaches to exploit the biosynthetic potential of microbial resources (including genome mining, metagenomic and epigenetic approaches), as well as biosynthetic chemistry tools to respond to product supply and novel screening alternatives that have lead to the discovery of novel chemistry. The second part reviews, in the form of case studies, some examples of bioactive molecules in the important therapeutic areas of antiinfectives, oncology and antiparasitics.

Frankenstein - Der Schöpfer

Roman
Author: Dean Koontz
Publisher: Heyne Verlag
ISBN: 3641069033
Category: Fiction
Page: 368
View: 847

Continue Reading →

Der Krieg gegen die Menschheit hat begonnen Zwei Jahre ist es her, dass Victor Frankenstein gestorben ist. Und dennoch setzt jemand namens »Victor Leben« sein Zerstörungswerk fort: In einem Städtchen in Montana werden Schritt für Schritt alle Menschen durch Angehörige der Neuen Rasse er setzt. Ein Probelauf für die ganze Welt. Wird es dem Polizisten duo Carson O’Connor und Michael Maddison mit ihren wenigen Verbündeten gelingen, den Wahnsinn zu stoppen?

Lehrbuch der Pharmakognosie und Phytopharmazie


Author: Ernst Steinegger,Rudolf Hänsel
Publisher: Springer-Verlag
ISBN: 3662083183
Category: Medical
Page: 804
View: 5417

Continue Reading →

Das bekannte Lehrbuch vermittelt in seiner vollständig überarbeiteten Neuauflage warenkundliche Informationen über pflanzliche Rohstoffe, die wichtig für die Herstellung von Arzneimitteln sind. Studierende der Pharmazie, Chemie, Biologie und Medizin ebenso wie Apotheker, Chemiker und Ärzte erhalten nicht nur Aufschluß über die Herkunft, chemische Zusammensetzung, Qualitätsprüfung und Anwendung pflanzlicher Arzneidrogen, sondern lernen auch die aus Arzneidrogen hergestellten Arzneimittel und deren Wirkungen kennen. Angestrebt wird eine Synopsis stofflich-phytochemischer, analytisch-pharmazeutischer und pharmakologisch-therapeutischer Aspekte. Durch das jetzt noch umfangreichere Kapitel über Arzneimittel, die als Vielkomponentengemische (Extrakte) verwendet werden, erhalten Apotheker und Arzt wissenschaftliche Voraussetzungen zur richtigen Beurteilung von Qualität, Wirksamkeit und Unbedenklichkeit von Phytopharmaka. die in pharmakologischen Nachschlagewerken kaum berücksichtigt werden. Das vorliegende Lehrbuch ist kein reines "Lehrbuch". Statt einer bloßen Anhäufung von Material handelt es sich hier um eine Darstellung des Themas aus multidisziplinärer Sicht. Ein umfangreiches Verzeichnis weiterführender Literatur soll dabei helfen, die erworbenen Kenntnisse zu vertiefen.

Endocrinology - E-Book

Adult and Pediatric
Author: J. Larry Jameson,Leslie J. De Groot
Publisher: Elsevier Health Sciences
ISBN: 1455711268
Category: Medical
Page: 3064
View: 4413

Continue Reading →

ENDOCRINOLOGY, edited by J. Larry Jameson, MD, PhD and Leslie J. De Groot, MD, has been considered the definitive source in its field for decades. Now this landmark reference has been exhaustively updated to bring you the latest clinical guidance on all aspects of diagnosis and treatment for the full range of endocrine and metabolism disorders, including new information on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors. Entirely new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis keep you well informed on today’s hot topics. You’ll benefit from unique, global perspectives on adult and pediatric endocrinology prepared by an international team of renowned authorities. This reference is optimally designed to help you succeed in your demanding practice and ensure the best possible outcomes for every patient. Overcome virtually any clinical challenge with detailed, expert coverage of every area of endocrinology, authored by hundreds of leading luminaries in the field. Provide state-of-the-art care with comprehensive updates on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors ... brand-new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis ... expanded coverage of sports performance, including testosterone, androgen research, and bone growth and deterioration ... and the newest discoveries in genetics and how they affect patient care. Make the best clinical decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion. Rapidly consult with trusted authorities thanks to new expert-opinion treatment strategies and recommendations. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information more quickly, while still getting the complete coverage you expect.

Small Animal Clinical Pharmacology and Therapeutics - E-Book


Author: Dawn Merton Boothe
Publisher: Elsevier Health Sciences
ISBN: 1437723578
Category: Medical
Page: 1348
View: 979

Continue Reading →

Confidently utilize the rapidly growing selection of pharmaceuticals used to treat small animals. Small Animal Pharmacology and Therapeutics, 2nd Edition helps you understand both the therapeutic uses of common pharmaceuticals and the pharmacology behind them, giving you all of the information you need to design and modify dosing regimens, identify factors that cause drugs to fail, and anticipate adverse drug reactions. Comprehensive approach emphasizes the use of drugs for prevention as well as treatment. Clear, consistent organization makes it easy to find the information you need when you need it. Dosage tables help you find essential pharmaceutical information at a glance. Pharmacogenetics chapter helps you understand how to use this emerging science to find the right dose for each patient, optimizing efficiency and minimizing toxicity. Routes of administration and sample pharmaceutical calculations provide fast, efficient access to comprehensive drug administration all in one inclusive resource. Multiple chapters on Antimicrobial Drugs and Antimicrobial Therapy highlight the impact of antimicrobial resistance on current practice.

Small Molecule DNA and RNA Binders

From Synthesis to Nucleic Acid Complexes
Author: Martine Demeunynck,Christian Bailly,W. David Wilson
Publisher: John Wiley & Sons
ISBN: 3527605665
Category: Science
Page: 754
View: 6055

Continue Reading →

The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.

Frankenstein - der Schatten

Roman
Author: Dean Koontz
Publisher: N.A
ISBN: 9783453565074
Category:
Page: 320
View: 668

Continue Reading →

Das grosse Finale der Frankenstein-Trilogie Während ein Hurrikan auf New Orleans zurast, rüstet sich die von Viktor Frankenstein erschaffene "Neue Rasse" zum grossen Angriff gegen die alte Menschheit. In einer Welt, die durch den verheerenden Wirbelsturm mit jeder Minute mehr aus den Fugen gerät, versuchen zwei Polizisten ein biologisches Experiment zu verhindern, das Millionen Menschen ausrotten könnte. Dean Koontz wurde 1945 in Pennsylvania geboren und lebt heute mit seiner Frau in Kalifornien. Seine zahlreichen Romane - Thriller und Horrorromane - wurden in 38 Sprachen übersetzt und sämtlich zu internationalen Bestsellern. Weltweit wurden bislang 400 Millionen Exemplare seiner Bücher verkauft. Zuletzt bei Heyne erschienen: 'Blindwütig'

Clinical Pharmacology


Author: Morris J. Brown,Pankaj Sharma,Peter N. Bennett
Publisher: Elsevier Health Sciences
ISBN: 0702051136
Category: Medical
Page: 640
View: 8028

Continue Reading →

A thorough knowledge of pharmacological and therapeutic principles is vital if drugs are to be used safely and effectively for increasingly informed patients. Those who clearly understand how drugs get into the body, how they produce their effects, what happens to them in the body, and how evidence of their therapeutic effect is assessed, will choose drugs more skilfully, and use them more safely and successfully than those who do not. Now in a fully revised 11th edition, Clinical Pharmacology is essential reading for undergraduate medical students, junior doctors and anyone concerned with evidence-based drug therapy. Introductory first three sections cover general principle of clinical pharmacology; five subsequent sections cover drug treatment of disease organised by body system. Retains approachable style set by the original author, Professor Laurence. Emphasis throughout is on evidence-based and safe drug prescribing. Indian Advisory Board will ensure content reflects the needs of the devloping world.

Clinical Radiation Oncology E-Book


Author: Leonard L. Gunderson,Joel E. Tepper
Publisher: Elsevier Health Sciences
ISBN: 1455726036
Category: Medical
Page: 1660
View: 876

Continue Reading →

With thorough updates throughout, Clinical Radiation Oncology provides the most comprehensive, authoritative, and up-to-date information available for treating patients with cancer. From a multidisciplinary perspective, this new edition, edited by Drs. Leonard L. Gunderson and Joel E. Tepper, examines the therapeutic management of specific disease sites based on both single-modality and combined-modality approaches - providing you with the well-rounded, cutting-edge guidance you need to offer the most effective treatments. A consistent chapter format, full-color design, and access to the full text at www.expertconsult.com make reference fast and easy. It is an ideal resource for mastering the latest, most effective techniques and modalities! Deepen your knowledge with a comprehensive, clinical approach to the scientific foundations of radiation oncology and general oncology as well as state-of-the-art techniques and modalities. Implement a multidisciplinary, "team care" approach to providing intricate treatment plans for patients, often in conjunction with medical oncologists, and surgeons. Broaden your understanding of the basic biology of the disease processes. Examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches. Quickly and easily find critical information thanks to an easily accessible, full-color design with over 800 color figures that clearly depict treatment techniques. Get broad multimodality perspectives and unique insights from a diverse team of respected editors and contributors –many of whom are new to this edition – affiliated with institutions across North America and internationally Access the fully searchable text anywhere, anytime at www.expertconsult.com, along with references, additional images and tables, video clips and more! Stay current with comprehensive updates throughout that include a new chapter on survivorship issues, and additional video clips on treatments such as prostate and penile cancer brachytherapy. Improve outcomes by providing the most effective treatment for each patient with expanded coverage of new modalities and treatment regimens. Understand and comply with the latest staging guidelines.

Inflammatory Processes:

Molecular Mechanisms and Therapeutic Opportunities
Author: L. Gordon Letts,Douglas W. Morgan
Publisher: Springer
ISBN: 3034884680
Category: Medical
Page: 144
View: 6131

Continue Reading →

In November 1998 many of the key leaders of new drug discovery for inflammatory diseases gathered at Hershey, Pennsylvania for the 9th International Conference of the Inflammation Research Association. The Conference was held over a five day period and provided a stimulating environment for the open exchange of important advances in basic inflammation research as well as new drug discovery and development. This book encompasses some of the highlights of several presentations made at the Conference. It contains some of the latest and important developments in the field of inflammation research. Topics include the status of eotaxin and chemokines in asthma and allergy, signal transduction and regulation of diverse mediators such as the JNK group of MAP kinases, TNF and IL-1 signaling of NF-kB as well as regulators of AP-1, macrophage metalloproteinases, lymphotoxin and further insights into the role of MCP-1 in disease. Also discussed are drug targets in rheumatoid and osteoarthritis, fibrotic diseases,...

Oncology of Infancy and Childhood E-Book


Author: Stuart H. Orkin,David E. Fisher,A. Thomas Look,Samuel Lux,David Ginsburg,David G. Nathan
Publisher: Elsevier Health Sciences
ISBN: 1437721389
Category: Medical
Page: 1392
View: 1487

Continue Reading →

To address the growing complexities of childhood cancer, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood has now been separated into two distinct volumes. With this volume devoted strictly to pediatric oncology, and another to pediatric hematology, you will be on the cutting edge of these two fields. This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. Written by the leading names in pediatric oncology, this resource is an essential tool for all who care for pediatric cancer patients. Offers comprehensive coverage of all pediatric cancers, including less common tumors, making this the most complete guide to pediatric cancer. Covers emerging research developments in cancer biology and therapeutics, both globally and in specific pediatric tumors. Includes a section on supportive care in pediatric oncology, written by authors who represent the critical subdisciplines involved in this important aspect of pediatric oncology. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines. Presents a full-color design that includes clear illustrative examples of the relevant pathology and clinical issues, for quick access to the answers you need. Incorporates the codified WHO classification for all lymphomas and leukemias.

Detection and Quantification of Antibodies to Biopharmaceuticals

Practical and Applied Considerations
Author: Michael G. Tovey
Publisher: John Wiley & Sons
ISBN: 1118075676
Category: Medical
Page: 432
View: 8349

Continue Reading →

The definitive book on the neutralization of recombinant biopharmaceuticals Recombinant biopharmaceuticals are an important tool for treating a range of illnesses; however, their efficacy can be severely impaired by their immunogenicity. When introduced into the body, these pharmaceuticals can cause the immune system to produce anti-drug antibodies (ADAs) that neutralize their effects. The first and only book to cover neutralization in connection with biopharmaceuticals and the measurement and application of neutralizing antibodies in modern medicine at any real length, Detection and Quantification of Antibodies to Biopharmaceuticals: Practical and Applied Considerations offers a comprehensive and in-depth look at all the principal aspects of the detection and quantification of antibodies that are essential to understanding and responding to the challenges they present. Bringing together a large-scale review of neutralization and biopharmaceuticals and the ability to measure, detect, and apply antibodies to modern science and medicine with international regulatory perspectives, the expectations of regulatory authorities, and the strengths and weaknesses of various assays, the book describes several novel ideas for detecting ADAs. Designed to serve as a resource for biopharmaceutical drug development, the book provides biotechnology companies and pharmaceutical drug development specialists, as well as non-experts, with key insights into the design, optimization, and qualification of assays, the establishment of sampling strategies, the choice of appropriate assay end-points, and data analysis for the detection and quantification of neutralizing antibodies.

Clinical Pharmacology

With STUDENTCONSULT Access
Author: Peter N. Bennett,Morris J. Brown
Publisher: Elsevier Health Sciences
ISBN: 0702039985
Category: Medical
Page: 704
View: 567

Continue Reading →

This book is for students, doctors and indeed for all concerned with evidence-based drug therapy. A knowledge of pharmacological and therapeutic principles is essential if drugs/medicines are to be used safely and effectively for increasingly informed and critical patients. Doctors who understand how drugs get into the body, how they produce their effects, what happens to them in the body, and how evidence of their therapeutic effect is assessed, will choose drugs more skilfully, and use them more successfully than those who do not. The principles involved are neither so numerous nor so difficult to understand as to deter any prescriber, including those whose primary interests lie elsewhere than in pharmacology. All who use drugs cannot escape either the moral or the legal 'duty of care' to prescribe in an informed and responsible way. Introductory first three sections cover general principle of clinical pharmacology; five subsequent sections cover drug treatment of disease organised by body system. Retains approachable style set by the original author, Professor Laurence. Emphasis throughout is on evidence-based and safe drug prescribing. New colour design Increased use of graphics Slightly shorter by removal of out of date material