Lab Math

A Handbook of Measurements, Calculations, and Other Quantitative Skills for Use at the Bench
Author: Dany Spencer Adams
Publisher: CSHL Press
ISBN: 9780879696344
Category: Mathematics
Page: 275
View: 3873

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Work at the biology bench requires an ever-increasing knowledge of mathematical methods and formulae. In Lab Math,Dany Spencer Adams has compiled the most common mathematical concepts and methods in molecular biology, and provided clear, straightforward guidance on their application to research investigations. Subjects range from basics such as scientific notation and measuring and making solutions, to more complex activities like quantifying and designing nucleic acids and analyzing protein activity. Tips on how to present mathematical data and statistical analysis are included. A reference section features useful tables, conversion charts and “plug and chug” equations for experimental procedures. This volume is an excellent, structured source of information that in many laboratories is often scattered and informally organized.

Lab Math

A Handbook of Measurements, Calculations, and Other Quantitative Skills for Use at the Bench
Author: Dany Spencer Adams
Publisher: N.A
ISBN: 9781936113712
Category: Mathematics
Page: 332
View: 3725

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Lab Math: A Handbook of Measurements, Calculations, and Other Quantitative Skills for Use at the Bench, 2nd edition, collects in one place the numbers and equations you rely on for your experiments and use to report your data-what they mean and how to use them-as well as easy-to-follow shortcuts for making the math easier. Written in an accessible and informal style, Lab Math describes basic mathematical principles and various tasks involving numbers, including how to calibrate lab equipment, how to make solutions, and the numbers involved in various methods for quantifying DNA, RNA, and proteins, and an all-new section on quantitative polymerase chain reaction. Basic statistical ideas and methods and the proper reporting of uncertainty are described in simple-to-understand language. Also included are reference tables, charts and "plug-and-chug" equation blanks for specific experimental procedures. Since the publication of the first edition in 2003, Lab Math has become an essential math reference and teaching resource for both on-the-spot practical information and background for understanding numerical tasks. Important additions in this second edition make Lab Math an even more useful tool for every laboratory.

Statistics at the Bench

A Step-by-step Handbook for Biologists
Author: Martina Bremer,Rebecca W. Doerge
Publisher: N.A
ISBN: N.A
Category: Mathematics
Page: 167
View: 7002

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Statistics at the Bench is a convenient bench-side companion for biologists, designed as a handy reference guide for elementary and intermediate statistical analyses. The expectations for biologists to have a more complete understanding of statistics are growing rapidly. New technologies and new areas of science, such as microarrays, next-generation sequencing, and proteomics, have dramatically increased the need for quantitative reasoning among biologists when designing experiments and interpreting results. Even the most routine informatics tools rely on statistical assumptions and methods that need to be appreciated if the scientific results are to be correct, understood, and exploited fully. This book is not a textbook. It is an essential handbook for working scientists. Statistics at the Bench provides a simple refresher for those who have forgotten what they once knew, and an overview for those wishing to use more quantitative reasoning in their research. Statistical methods, as well as guidelines for the interpretation of results, are explained using simple examples. Throughout the book, examples are accompanied by detailed Excel commands for easy reference.

At the Bench

A Laboratory Navigator
Author: Kathy Barker
Publisher: CSHL Press
ISBN: 9780879697082
Category: Science
Page: 465
View: 661

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A clue hidden in a toy ship leads Tintin on a dangerous treasure hunt.

Lab Ref

A Handbook of Recipes, Reagents, and Other Reference Tools for Use at the Bench
Author: Albert S. Mellick
Publisher: CSHL Press
ISBN: 0879698152
Category: Science
Page: 248
View: 7038

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"The first Lab Ref volume compiled recipes and reference data drawn from a selection of our manuals and was intended to save time and spare frustration." ... "In the same spirit, Lab Ref 2 again assembles in one place a new selection of reference information that should maximize the volume's value in a crowded laboratory environment."--Note.

Experimental Design for Biologists


Author: David J. Glass
Publisher: CSHL Press
ISBN: 0879697350
Category: Science
Page: 206
View: 6866

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Experimental Design for Biologists explains how to establish the framework for an experimental project, including the effects of using a hypothesis–driven approach versus a question/answer approach, how to set up a system, design experiments within that system, and how to determine and use the correct set of controls. Separate chapters are devoted to the negative control, the positive control, and other categories of controls which are perhaps less recognized, such as “assumption controls”, and “experimentalist controls.” Further, there are sections on establishing the experimental system, which includes performing critical “system controls”. While the book does reference the use of statistics, statistics is not the focus of this book, but rather the way the scientist should go about framing an experimental question, establishing a validated system to answer the question, and deriving verifiable models from experimental data. There is often very little formal training in this area for biologists; therefore this text serves as an essential teaching tool for understanding the theory and practice of designing a research plan.

Performance Evaluation and Attribution of Security Portfolios


Author: Bernd R. Fischer,Russ Wermers
Publisher: Academic Press
ISBN: 0080926525
Category: Business & Economics
Page: 724
View: 5868

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Just how successful is that investment? Measuring portfolio performance requires evaluation (measuring portfolio results against benchmarks) and attribution (determining individual results of the portfolio's parts), In this book, a professor and an asset manager show readers how to use theories, applications, and real data to understand these tools. Unlike others, Fischer and Wermers teach readers how to pick the theories and applications that fit their specific needs. With material inspired by the recent financial crisis, Fischer and Wermers bring new clarity to defining investment success. Gives readers the theories and the empirical tools to handle their own data Features practice problems formerly from the CFA Program curriculum.

Measuring Shape


Author: F. Brent Neal,John C. Russ
Publisher: CRC Press
ISBN: 1351833146
Category: Computers
Page: 440
View: 6186

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"John Russ is the master of explaining how image processing gets applied to real-world situations. With Brent Neal, he’s done it again in Measuring Shape, this time explaining an expanded toolbox of techniques that includes useful, state-of-the-art methods that can be applied to the broad problem of understanding, characterizing, and measuring shape. He has a gift for finding the kernel of a particular algorithm, explaining it in simple terms, then giving concrete examples that are easily understood. His perspective comes from solving real-world problems and separating out what works in practice from what is just an abstract curiosity."? —Tom Malzbender, Hewlett-Packard Laboratories, Palo Alto, California, USA Useful for those working in fields including industrial quality control, research, and security applications, Measuring Shape is a handbook for the practical application of shape measurement. Covering a wide range of shape measurements likely to be encountered in the literature and in software packages, this book presents an intentionally diverse set of examples that illustrate and enable readers to compare methods used for measurement and quantitative description of 2D and 3D shapes. It stands apart through its focus on examples and applications, which help readers quickly grasp the usefulness of presented techniques without having to approach them through the underlying mathematics. An elusive concept, shape is a principal governing factor in determining the behavior of objects and structures. Essential to recognizing and classifying objects, it is the central link in manmade and natural processes. Shape dictates everything from the stiffness of a construction beam, to the ability of a leaf to catch water, to the marketing and packaging of consumer products. This book emphasizes techniques that are quantitative and produce a meaningful yet compact set of numerical values that can be used for statistical analysis, comparison, correlation, classification, and identification. Written by two renowned authors from both industry and academia, this resource explains why users should select a particular method, rather than simply discussing how to use it. Showcasing each process in a clear, accessible, and well-organized way, they explore why a particular one might be appropriate in a given situation, yet a poor choice in another. Providing extensive examples, plus full mathematical descriptions of the various measurements involved, they detail the advantages and limitations of each method and explain the ways they can be implemented to discover important correlations between shape and object history or behavior. This uncommon assembly of information also includes sets of data on real-world objects that are used to compare the performance and utility of the various presented approaches.

I Wish I'd Made You Angry Earlier

Essays on Science, Scientists, and Humanity
Author: Max F. Perutz
Publisher: Oxford University Press, USA
ISBN: 9780198590279
Category: Creative ability in science
Page: 354
View: 8511

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This collection of essays from Nobel Laureate Max Perutz explores a wide range of scientific and personal topics with insight and lucidity. It includes lively anecdotes about key figures in 20th-century science.

Calcium Techniques

A Laboratory Manual
Author: Jan B. Parys,Martin D. Bootman,David I. Yule,Geert Bultynck
Publisher: N.A
ISBN: 9781936113583
Category: Science
Page: 592
View: 2877

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"This laboratory manual provides step-by-step protocols for studying many facets of Ca2+ signaling, as well as background information on the principles and applications of the techniques. Contributors discuss how to use fluorescent, luminescent, and genetically encoded Ca2+ probes in conjunction with state-of-the-art imaging modalities to characterize Ca2+ signals. Electrophysiological measurements of Ca2+ channel activity are described, as are radioactive Ca2+ flux assays and methods to investigate signaling mediated by specific Ca2+-mobilizing messengers (IP3, cADPR, and NAADP). Techniques to modulate and suppress intra- and intercellular signals are also provided. Each protocol is complete with a list of required materials, detailed recipes for media and reagents, and troubleshooting advice"--

Molecular Cloning

A Laboratory Manual
Author: Joseph Sambrook,David William Russell
Publisher: CSHL Press
ISBN: 9780879695774
Category: Science
Page: 2344
View: 5635

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The first two editions of this manual have been mainstays of molecular biology for nearly twenty years, with an unrivalled reputation for reliability, accuracy, and clarity. In this new edition, authors Joseph Sambrook and David Russell have completely updated the book, revising every protocol and adding a mass of new material, to broaden its scope and maintain its unbeatable value for studies in genetics, molecular cell biology, developmental biology, microbiology, neuroscience, and immunology. Handsomely redesigned and presented in new bindings of proven durability, this three–volume work is essential for everyone using today’s biomolecular techniques. The opening chapters describe essential techniques, some well–established, some new, that are used every day in the best laboratories for isolating, analyzing and cloning DNA molecules, both large and small. These are followed by chapters on cDNA cloning and exon trapping, amplification of DNA, generation and use of nucleic acid probes, mutagenesis, and DNA sequencing. The concluding chapters deal with methods to screen expression libraries, express cloned genes in both prokaryotes and eukaryotic cells, analyze transcripts and proteins, and detect protein–protein interactions. The Appendix is a compendium of reagents, vectors, media, technical suppliers, kits, electronic resources and other essential information. As in earlier editions, this is the only manual that explains how to achieve success in cloning and provides a wealth of information about why techniques work, how they were first developed, and how they have evolved.

Essential Laboratory Mathematics

Concepts and Applications for the Chemical and Clinical Laboratory Technician
Author: Catherine W. Johnson (MAed/Math.),Catherine W. Johnson,Daniel L. Timmons,Pamela E. Hall
Publisher: Cengage Learning
ISBN: 9780766838260
Category: Medical
Page: 268
View: 5071

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This manual offers a clear review of basic mathematical topics most often used in clinical and medical laboratories. It is the perfect refresher for participating technicians and will be a handy on-site reference tooll users can go directly to the material that they need to review. Application problems and hands-on laboratory exercises at the end of each chapter reinforce material and give users the opportunity to assess their mastery of the presented skills.

Improving Measurement of Productivity in Higher Education


Author: Panel on Measuring Higher Education Productivity: Conceptual Framework and Data Needs,Committee on National Statistics,Board on Testing and Assessment,Division of Behavioral and Social Sciences and Education,National Research Council
Publisher: National Academies Press
ISBN: 0309257751
Category: Education
Page: 207
View: 8618

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Higher education is a linchpin of the American economy and society: teaching and research at colleges and universities contribute significantly to the nation's economic activity, both directly and through their impact on future growth; federal and state governments support teaching and research with billions of taxpayers' dollars; and individuals, communities, and the nation gain from the learning and innovation that occur in higher education. In the current environment of increasing tuition and shrinking public funds, a sense of urgency has emerged to better track the performance of colleges and universities in the hope that their costs can be contained without compromising quality or accessibility. Improving Measurement of Productivity in Higher Education presents an analytically well-defined concept of productivity in higher education and recommends empirically valid and operationally practical guidelines for measuring it. In addition to its obvious policy and research value, improved measures of productivity may generate insights that potentially lead to enhanced departmental, institutional, or system educational processes. Improving Measurement of Productivity in Higher Education constructs valid productivity measures to supplement the body of information used to guide resource allocation decisions at the system, state, and national levels and to assist policymakers who must assess investments in higher education against other compelling demands on scarce resources. By portraying the productive process in detail, this report will allow stakeholders to better understand the complexities of--and potential approaches to--measuring institution, system and national-level performance in higher education.

Handbook of Biological Confocal Microscopy


Author: James Pawley
Publisher: Springer Science & Business Media
ISBN: 1461571332
Category: Medical
Page: 232
View: 668

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In 1987 the Electron Microscopy Society of America (EMSA) going to drive important scientific discoveries across wide areas under the leadership of J. P. Revel (Cal Tech) initiated a major of physiology, cellular biology and neurobiology. They had been program to present a discussion of recent advances in light looking for a forum in which they could advance the state of microscopy as part of the annual meeting. The result was three the art of confocal microscopy, alert manufacturers to the lim special LM sessions at the Milwaukee meeting in August 1988: itations of current instruments, and catalyze progress toward The LM Forum, organized by me, and Symposia on Confocal new directions in confocal instrument development. LM, organized by G. Schatten (Madison), and on Integrated These goals were so close to those of the EMSA project that Acoustic/LM/EM organized by C. Rieder (Albany). In addition, the two groups decided to join forces with EMSA to provide there was an optical micro-analysis session emphasizing Raman the organization and the venue for a Confocal Workshop and techniques, organized by the Microbeam Analysis Society, for NSF to provide the financial support for the speakers expenses a total of 40 invited and 30 contributed papers on optical tech and for the publication of extended abstracts.

Using the Biological Literature

A Practical Guide, Fourth Edition
Author: Diane Schmidt
Publisher: CRC Press
ISBN: 146655858X
Category: Language Arts & Disciplines
Page: 412
View: 2077

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The biological sciences cover a broad array of literature types, from younger fields like molecular biology with its reliance on recent journal articles, genomic databases, and protocol manuals to classic fields such as taxonomy with its scattered literature found in monographs and journals from the past three centuries. Using the Biological Literature: A Practical Guide, Fourth Edition is an annotated guide to selected resources in the biological sciences, presenting a wide-ranging list of important sources. This completely revised edition contains numerous new resources and descriptions of all entries including textbooks. The guide emphasizes current materials in the English language and includes retrospective references for historical perspective and to provide access to the taxonomic literature. It covers both print and electronic resources including monographs, journals, databases, indexes and abstracting tools, websites, and associations—providing users with listings of authoritative informational resources of both classical and recently published works. With chapters devoted to each of the main fields in the basic biological sciences, this book offers a guide to the best and most up-to-date resources in biology. It is appropriate for anyone interested in searching the biological literature, from undergraduate students to faculty, researchers, and librarians. The guide includes a supplementary website dedicated to keeping URLs of electronic and web-based resources up to date, a popular feature continued from the third edition.

The AGT Cytogenetics Laboratory Manual


Author: Marilyn S. Arsham,Margaret J. Barch,Helen J. Lawce
Publisher: John Wiley & Sons
ISBN: 1119061229
Category: Science
Page: 1218
View: 3077

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Cytogenetics is a segment of the evolving cytogenomic branch of genetics that explores the genetic makeup of a cell, in particular chromosomes both in metaphase and in interphase cycles, as well as at the molecular level. It utilizes an assortment of procedures to illuminate both the full complement of chromosomes and a targeted region within a specific chromosome. These investigative tools include routine analysis of G-banded chromosomes, specialized stains that address specific chromosomal structures, and molecular probes, such as fluorescence in situ hybridization and chromosome microarray analysis, which employ a variety of methods to highlight a region as small as a single, specific genetic sequence under investigation. The AGT Cytogenetics Laboratory Manual, Fourth Edition offers a comprehensive treatment of the diagnostic tests offered by this clinical laboratory environment and explains the scientific theories behind those procedures. One of the most valuable assets is its rich compilation of laboratory-tested protocols currently being used in leading laboratories, along with practical advice for nearly every area of interest to cytogeneticists. In addition to covering essential topics that have been the backbone of cytogenetics for over 60 years, such as the basic components of a cell, use of a microscope, human tissue processing for cytogenetic analysis (prenatal, constitutional, and neoplastic), laboratory safety, and the mechanisms behind chromosome rearrangement and aneuploidy, this edition introduces new and expanded chapters that reflect the intuitive experience of its authors. Some of these new topics include a unique collection of chromosome heteromorphisms; clinical examples of genomic imprinting; an example-driven overview of chromosomal microarray; mathematics specifically geared for the cytogeneticist; usage of ISCN's cytogenetic language; tips for laboratory management; examples of laboratory information systems; a collection of Internet and library resources; and a special chapter on animal chromosomes for the research and zoo cytogeneticist. The range of topics is thus broad yet comprehensive, offering the student with a resource that teaches the procedures performed in the cytogenetics laboratory environment, and the laboratory professional with a peer-reviewed reference that explores the multiple facets behind each of these procedures. Topic coverage is rich in detail, yet presented with the student in mind, making it a useful resource for researchers, clinicians, and laboratory professionals, as well as students in a university or medical school that offers introductory or laboratory-related courses exploring cytogenetics' role within medical genetics. Reviews for the third edition: "A collection of protocols and explanations for cytogenetic techniques from the common to the peculiar." "An excellent book. Looking forward to an updated version."

Linne & Ringsrud's Clinical Laboratory Science

The Basics and Routine Techniques
Author: Mary Louise Turgeon
Publisher: Elsevier Health Sciences
ISBN: 0323370616
Category: Medical
Page: 688
View: 9911

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Using a discipline-by-discipline approach, Linne & Ringsrud's Clinical Laboratory Science: Concepts, Procedures, and Clinical Applications, 7th Edition provides a fundamental overview of the skills and techniques you need to work in a clinical laboratory and perform routine clinical lab tests. Coverage of basic laboratory techniques includes key topics such as safety, measurement techniques, and quality assessment. Clear, straightforward instructions simplify lab procedures, and are described in the CLSI (Clinical and Laboratory Standards Institute) format. Written by well-known CLS educator Mary Louise Turgeon, this text includes perforated pages so you can easily detach procedure sheets and use them as a reference in the lab! Hands-on procedures guide you through the exact steps you'll perform in the lab. Review questions at the end of each chapter help you assess your understanding and identify areas requiring additional study. A broad scope makes this text an ideal introduction to clinical laboratory science at various levels, including CLS/MT, CLT/MLT, and Medical Assisting, and reflects the taxonomy levels of the CLS/MT and CLT/MLT exams. Detailed full-color illustrations show what you will see under the microscope. An Evolve companion website provides convenient online access to all of the procedures in the text, a glossary, audio glossary, and links to additional information. Case studies include critical thinking and multiple-choice questions, providing the opportunity to apply content to real-life scenarios. Learning objectives help you study more effectively and provide measurable outcomes to achieve by completing the material. Streamlined approach makes it easier to learn the most essential information on individual disciplines in clinical lab science. Experienced author, speaker, and educator Mary Lou Turgeon is well known for providing insight into the rapidly changing field of clinical laboratory science. Convenient glossary makes it easy to look up definitions without having to search through each chapter. NEW! Procedure worksheets have been added to most chapters; perforated pages make it easy for students to remove for use in the lab and for assignment of review questions as homework. NEW! Instrumentation updates show new technology being used in the lab. NEW! Additional key terms in each chapter cover need-to-know terminology. NEW! Additional tables and figures in each chapter clarify clinical lab science concepts.

A Bioinformatics Guide for Molecular Biologists


Author: Sarah J. Aerni,Sarah Aerni,Marina Sirota
Publisher: N.A
ISBN: 9781936113224
Category: Medical
Page: 319
View: 7007

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A more complete understanding of bioinformatics offered in this title will allow the reader to become comfortable with them, encouraging their use and thus helping to make sense of the vast accumulation of data.

Ahead of the Curve

Hidden Breakthroughs in the Biosciences
Author: Dany Adams
Publisher: Iop Expanding Physics
ISBN: 9780750313278
Category: Science
Page: 150
View: 5234

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This unique book is a compendium of carefully curated published papers in the biosciences, which have (or will) precipitate a profound change in prevailing paradigms and research programs. A mix of new and classic papers, it shows the limitations of current thought or identifies novel vistas for investigations that have not yet been explored. The purpose of the book is to highlight scientific gems, most unrecognized, that suggest revisions to key pillars of thought in the biological sciences and further the education of young scientists. This will be achieved by including reprints of papers that demonstrate counter-paradigm, novel directions for future research featuring commentary from current, notable researchers in a variety of areas.

Effective Computation in Physics

Field Guide to Research with Python
Author: Anthony Scopatz,Kathryn D. Huff
Publisher: "O'Reilly Media, Inc."
ISBN: 1491901586
Category: Science
Page: 552
View: 7313

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More physicists today are taking on the role of software developer as part of their research, but software development isn’t always easy or obvious, even for physicists. This practical book teaches essential software development skills to help you automate and accomplish nearly any aspect of research in a physics-based field. Written by two PhDs in nuclear engineering, this book includes practical examples drawn from a working knowledge of physics concepts. You’ll learn how to use the Python programming language to perform everything from collecting and analyzing data to building software and publishing your results. In four parts, this book includes: Getting Started: Jump into Python, the command line, data containers, functions, flow control and logic, and classes and objects Getting It Done: Learn about regular expressions, analysis and visualization, NumPy, storing data in files and HDF5, important data structures in physics, computing in parallel, and deploying software Getting It Right: Build pipelines and software, learn to use local and remote version control, and debug and test your code Getting It Out There: Document your code, process and publish your findings, and collaborate efficiently; dive into software licenses, ownership, and copyright procedures