Introduction to Glycobiology

Author: Maureen E. Taylor,Kurt Drickamer
Publisher: Oxford University Press
ISBN: 0199569118
Category: Medical
Page: 283
View: 8526

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Introduction to Glycobiology reveals the true impact of the sugars on biological systems, explaining their function at the molecular, cellular, and organismal level and their clinical relevance.

Glycobiology and Human Diseases

Author: Gherman Wiederschain
Publisher: CRC Press
ISBN: 1498709192
Category: Medical
Page: 334
View: 6936

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This book discusses glycobiology and various forms of human diseases. Topics covered include immunoglobulins, inflammation and glycosylation, the role and therapeutic significance of natural anti-glycan antibodies in malignancies and in normal and aberrant pregnancy, identifying urinary glycans as a possible method for the diagnosis of lysosomal storage diseases, glycobiology of human milk (biological roles and diseases) and pectins as biological modulators of human physiological reactions. The book includes analysis of comprehensive data and some productive conclusions and perspectives.

Glycome Informatics

Methods and Applications
Author: Kiyoko F. Aoki-Kinoshita
Publisher: CRC Press
ISBN: 1420083368
Category: Science
Page: 256
View: 6462

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A Focused, State-of-the-Art Overview of This Evolving Field Presents Various Techniques for Glycoinformatics The development and use of informatics tools and databases for glycobiology and glycomics research have increased considerably in recent years. In addition to accumulating well-structured glyco-related data, researchers have now developed semi-automated methods for the annotation of mass spectral data and algorithms for capturing patterns in glycan structure data. These techniques have enabled researchers to gain a better understanding of how these complex structures affect protein function and other biological processes, including cancer. One of the few up-to-date books available in this important area, Glycome Informatics: Methods and Applications covers all known informatics methods pertaining to the study of glycans. It discusses the current status of carbohydrate databases, the latest analytical techniques, and the informatics needed for rapid progress in glycomics research. Providing an overall understanding of glycobiology, this self-contained guide focuses on the development of glycome informatics methods and current problems faced by researchers. It explains how to implement informatics methods in glycobiology. The author includes the required background material on glycobiology as well as the mathematical concepts needed to understand advanced mining and algorithmic techniques. She also suggests project themes for readers looking to begin research in the field.

Introduction to Bioorganic Chemistry and Chemical Biology

Author: David Van Vranken,Gregory A. Weiss
Publisher: Garland Science
ISBN: 1135054827
Category: Medical
Page: 504
View: 8002

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Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.

Marine Glycobiology

Principles and Applications
Author: Se-Kwon Kim
Publisher: CRC Press
ISBN: 1498709621
Category: Medical
Page: 520
View: 9382

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Marine glycobiology is an emerging and exciting area in the field of science and medicine. Glycobiology, the study of the structure and function of carbohydrates and carbohydrate-containing molecules, is fundamental to all biological systems and represents a developing field of science that has made huge advances in the last half-century. This book revolutionizes the concept of marine glycobiology, focusing on the latest principles and applications of marine glycobiology and their relationships.

Ion Mobility Spectrometry - Mass Spectrometry

Theory and Applications
Author: Charles L. Wilkins,Sarah Trimpin
Publisher: CRC Press
ISBN: 9781439813256
Category: House & Home
Page: 374
View: 4206

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The analytical power of ion mobility spectrometry-mass spectrometry (IMS-MS) instruments is poised to advance this technology from research to analytical laboratories. Exploring these developments at this critical juncture, Ion Mobility Spectrometry-Mass Spectrometry: Theory and Applications covers the tools, techniques, and applications involved when molecular size and shape information is combined with the well-known analytical advantages of high-performance mass spectrometry. One of the Most Exciting Developments in Contemporary Mass Spectrometry After presenting an overview chapter and the fundamentals, the book focuses on instrumentation and ionization sources. It describes an ion-mobility-capable quadrupole time-of-flight mass spectrometer, the differential mobility analyzer, a cryogenic-temperature ion mobility mass spectrometer, the atmospheric solids analysis probe method, and laserspray ionization. In the final applications-oriented chapters, the contributors explore how homebuilt and commercial instruments using electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) methods are employed to solve biological and synthetic issues. Harness the Power of IMS-MS for Analyzing Complex Substances This work helps readers unfamiliar with IMS-MS to understand its fundamental theory and practical applications. It also encourages them to investigate the potential analytical uses of IMS-MS and further explore the power of this method. Numerous color figures are included on a CD-ROM.

More Than a Memoir

Publisher: Xlibris Corporation
ISBN: 1469114402
Category: Biography & Autobiography
Page: 431
View: 8288

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In this unusual autobiography you will find the full story of a life spanning much of the twentieth century. Selective reading will disclose How a teacher/scientist may develop The importance of focus and integrity The fascination of doing chemical and biochemical research with students and colleagues The excitement of discovery and of facing new challenges Personal details about family life and friendships Career choices and diversions Plus In the 23 (!) appendices, you will find details concerning Other activities attendant upon a career in science The influence of conferences, symposia, and international scientific connections The coworkers who built the reputation of the author

Bioinformatics for Glycobiology and Glycomics

An Introduction
Author: Claus-Wilhelm von der Lieth,Thomas Luetteke,Martin Frank
Publisher: John Wiley & Sons
ISBN: 9780470029602
Category: Medical
Page: 494
View: 6867

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This book is the first to be dedicated to the bioinformatics of carbohydrates and glycoproteins. It provides an introduction to this emerging field of science both for the experimentalist working in glycobiology and glycomics, and also for the computer scientist looking for background information for the development of highly sophisticated algorithmic approaches. The book provides an overview of the state-of-the-art in the field, with reviews on databases, and the tools in use for analysis, interpretation, and prediction of the structures of complex carbohydrates, and demonstrates the value of bioinformatics for glycobiology. The availability of comprehensive databases and corresponding bioinformatics tools, to access and analyse the large amounts of experimental data relating to the structure of carbohydrates, will be a prerequisite for the success of the large-scale glycomics projects that aim to decipher new, so far unknown, biological functions of glycans. Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis and experimental costs. For a complete understanding of the molecular processes in which carbohydrates are involved, such as protein–carbohydrate interactions and the impact of glycosylation on protein function, knowledge of the 3D structure of the carbohydrate, the protein–carbohydrate complex, or the glycoprotein is often indispensable. This book provides a thorough introduction into methods used for conformational analysis of carbohydrates. Key features: Describes bioinformatic approaches to handle carbohydrate-active enzymes and glycosylation. Provides an overview on bioinformatics tools that facilitate analysis of carbohydrate structures. Gives introduction into molecular modelling of carbohydrate 3D structure and carbohydrates contained in the Protein Databank. Assumes only a basic knowledge of biology and bioinformatics.

Pacific Symposium on Biocomputing 2002, Kauai, Hawaii, 3-7 January 2002

Author: Russ B. Altman
Publisher: World Scientific
ISBN: 9789812799623
Category: Medical
Page: 700
View: 2662

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The Pacific Symposium on Biocomputing brings together key researchers from the international biocomputing community. It is designed to be maximally responsive to the need for critical mass in subdisciplines within biocomputing. This book contains peer-reviewed articles in computational biology. Contents: Human Genome Variation: Disease, Drug Response, and Clinical Phenotypes; Genome-Wide Analysis and Comparative Genomics; Expanding Proteomics to Glycobiology; Literature Data Mining for Biology; Genome, Pathway and Interaction Bioinformatics; Phylogenetic Genomics and Genomic Phylogenetics; Proteins: Structure, Function and Evolution. Readership: Graduate students, academics and industrialists in bioinformatics.

Glycobiology of the Nervous System

Author: Robert K. Yu,Cara-Lynne Schengrund
Publisher: Springer
ISBN: 1493911546
Category: Medical
Page: 584
View: 3242

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A thorough introduction is provided to the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic information as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. The breadth and depth of topics covered make it an essential reference for those new to the field as well more seasoned investigators.

Introduction to Enzyme and Coenzyme Chemistry

Author: Tim Bugg
Publisher: John Wiley & Sons
ISBN: 1119995957
Category: Medical
Page: 279
View: 5897

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Looking at enzymes from an organic chemistry perspective, this updated reference includes information on recent advances in our understanding of enzyme action; topical examples to illustrate key points; two-color figures of the active sites of enzymes discussed in the text to illustrate the interplay between enzyme structure and function; and end-of-chapter problems to allow readers to check their understanding of the material. This concise but comprehensive guide is essential for undergraduate and postgraduate students of organic, bio-organic, and medicinal chemistry, chemical biology, biochemistry, and biotechnology.


The Sweet Molecules of Life
Author: Robert V. Stick
Publisher: Elsevier
ISBN: 0080500692
Category: Science
Page: 256
View: 8395

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This book is on carbohydrates-the essential molecules that give you energy. They are the building blocks of life. This book delivers up-to-date coverage on all aspects of carbohydrate chemistry. The molecules are sometimes sugars, i.e. "sweet," hence the subtitle "The Sweet Molecules of Life." Carbohydrates first gives the "nuts and bolts" of carbohydrate chemistry, enabling the reader to appreciate the subsequent chapters on protecting groups and the reactions of monosaccharides. (The protecting groups do just that-they are put on the molecules as a temporary measure during one or more reactions to stop the wrong bit of the molecule being changed during that reaction.) * Introduces the basic chemistry of carbohydrates * Describes the concepts, protecting groups, and reactions of carbohydrates * Includes all aspects of the synthesis of the glycosidic linkage * Gives an introduction to glycobiology and vaccines * Includes references to carbohydrate literature

Sialo-Xenoantigenic Glycobiology

Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation
Author: Kwon-Ho Song,Cheorl-Ho Kim
Publisher: Springer Science & Business Media
ISBN: 3642340946
Category: Technology & Engineering
Page: 64
View: 6609

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Carbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid–based xenoantigenes. In pig to human xenotransplantation, exposure of pig organs to human blood results in hyper acute rejection (HAR), caused by differences in carbohydrate epitopes between human and pig vascular endothelia. Although Gal-antigen as major antigen was eliminated, the remaining non-Gal antigens are considered to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens specific to natural antibodies in human. To overcome rejection responses such as HAR, studies of genes involved in carbohydrate antigens, causing xenoantigenicity, are necessary. Knowledge of pig glycosyltransferases are also useful to apply to xenoantigen masking or identification of the xenoantigenic sialylglycan(s). In the first chapter the screening for pig glycosyltransferase genes for xenoantigens is presented. In the chapter II to IV the cloning, characterization, and investigation of the regulatory mechanism of the pig CMAH gene in NeuGc biosynthesis is shown. Lastly, the effects of an alteration of pig glycosylation patterns on human serum-mediated cytotoxicity, caused by human sialyltransferases including hST6GalNAc IV is presented.

Essentials of Glycobiology

Author: Ajit Varki
Publisher: CSHL Press
ISBN: 9780879696818
Category: Science
Page: 653
View: 425

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Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. They participate in activities as diverse as protein folding, leukocyte physiology, and microbial pathogenesis. Genetic defects in their assembly are at the root of a growing list of human diseases. Essentials of Glycobiology describes their biogenesis and function and offers a useful gateway to the understanding of glycans.


Author: N.A
Publisher: Academic Press
ISBN: 9780123810007
Category: Science
Page: 640
View: 6385

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In this 3 volume collection focusing on glycomics, readers will appreciate how such discoveries were made and how such methods can be applied for readers’ own research efforts Each chapter has been designed so that enough scientific background will be given in each chapter for further development of methods by readers themselves Useful for all levels of scientists starting from the last years of colleges, graduate students, postdoctoral fellows to professors and to all levels of scientists in research institutes including industry


Author: Minoru Fukuda
Publisher: Elsevier
ISBN: 0080468993
Category: Science
Page: 424
View: 959

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In the past decade, there has been an explosion of progress in understanding the roles of carbohydrates in biological systems. This explosive progress was made with the efforts in determining the roles of carbohydrates in immunology, neurobiology and many other disciplines, examining each unique system and employing new technology. This volume represents the first of three in the Methods in Enzymology series, including Glycomics (vol. 416) and Functional Glycomics (vol. 417), dedicated to disseminating information on methods in determining the biological roles of carbohydrates. These books are designed to provide an introduction of new methods to a large variety of readers who would like to participate in and contribute to the advancement of glycobiology. The methods covered include structural analysis of carbohydrates, biological and chemical synthesis of carbohydrates, expression and determination of ligands for carbohydrate-binding proteins, gene expression profiling including micro array, and generation of gene knockout mice and their phenotype analyses.

Glycobiology and Medicine

Author: John S. Axford
Publisher: Springer Science & Business Media
ISBN: 9780306477829
Category: Medical
Page: 292
View: 5496

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St. Georges Hospital and Medical School, London, UK. Summarizes some of the major recent developments in glycobiology as a result from the 6th Glycobiology and Medicine meeting. For researchers. DNLM: Glycosylation--Congresses.

Microbial Glycobiology

Structures, Relevance and Applications
Author: Anthony P Moran
Publisher: Elsevier
ISBN: 9780080923246
Category: Science
Page: 1036
View: 7633

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This book presents in an easy-to-read format a summary of the important central aspects of microbial glycobiology, i.e. the study of carbohydrates as related to the biology of microorganisms. Microbial glycobiology represents a multidisciplinary and emerging area with implications for a range of basic and applied research fields, as well as having industrial, medical and biotechnological implications. Individual chapters provided by leading international scientists in the field yield insightful, concise and stimulating reviews Provides researchers with an overview and synthesis of the latest research Each chapter begins with a brief 200 word Summary/Abstract detailing the topic and focus of the chapter, as well as the concepts to be addressed Allows researchers to see at a glance what each chapter will cover Each chapter includes a Research Focus Box Identifies important problems that still need to be solved and areas that require further investigation

Glycobiology Protocols

Author: Inka Brockhausen
Publisher: Springer Science & Business Media
ISBN: 1597451673
Category: Science
Page: 381
View: 9037

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The protocols in this volume contain specific methods for the analysis of the structures or functions of glycoconjugates, as well as of glycosyltransferases and glycosidases involved in the biosynthesis of glycans. The methods described for a specific system can usually be modified for investigations of similar biomolecules and tissues or cell types.

Functional and Molecular Glycobiology

Author: Susan A. Brooks,Miriam V. Dwek,Udo Schumacher
Publisher: Garland Pub
ISBN: 9781859960226
Category: Science
Page: 354
View: 2049

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Functional and Molecular Glycobiology explains the chemistry of carbohydrates, and the biosynthesis and diversity of different types of glycans. It looks at the functional role of glycoconjugate compounds in normal cellular processes, in both disease and development. The book also describes how these compounds can be studied, analysed and manipulated for use in biotechnology. Functional and Molecular Glycobiology is a unique introduction to the field bridging the gap between introductory books and current research.