Interpretation of Mass Spectra


Author: Fred W. McLafferty,František Tureček
Publisher: University Science Books
ISBN: 9780935702255
Category: Science
Page: 371
View: 3336

Continue Reading →

Published by University Science Books, 20 Edgehill Rd., Mill Valley, CA 94941. The first edition was published more than 25 years ago, the third, in 1980. Automated computer-matching procedures are still only an aid to, not a replacement for, the skilled interpreter; and the path to that skill, as emphasized in every edition of this text, is practice. Annotation copyright by Book News, Inc., Portland, OR

Interpretation of Mass Spectra of Organic Compounds


Author: Mynard Hamming
Publisher: Elsevier
ISBN: 0323143148
Category: Science
Page: 708
View: 6019

Continue Reading →

Interpretation of Mass Spectra of Organic Compounds outlines the basic instrumentation, sample handling techniques, and procedures used in the interpretation of mass spectra of organic compounds. The fundamental concepts of ionization, fragmentation, and rearrangement of ions as found in mass spectra are covered in some detail, along with the rectangular array and interpretation maps. Computerization of mass spectral data is also discussed. This book consists of nine chapters and begins with a historical overview of mass spectrometry and a discussion on some important developments in the field, along with a summary of interpretation objectives and methods. The following chapters focus on instruments, ion sources, and detectors; recording of the mass spectrum and the instrumental and sample variables affecting the mass spectrum; sample introduction systems; and fragmentation reactions. Correlations as applied to interpretations are also considered, with emphasis on applications of the branching rule as well as beta-bond and alpha-bond cleavages. Example interpretations, calculations, data-processing procedures, and computer programs are included. This monograph is intended for organic chemists, biochemists, mass spectroscopists, technicians, managers, and others concerned with the whys and wherefores of mass spectrometry.

Massenspektrometrie

Ein Lehrbuch
Author: Jürgen H Gross
Publisher: Springer-Verlag
ISBN: 3827429811
Category: Science
Page: 802
View: 306

Continue Reading →

Mit Massenspektrometrie – ein Lehrbuch liegt ein Werk vor, das mit seiner umfassenden, präzisen Darstellung sowie seinen vielen gelungenen Illustrationen und Fotos eine Lücke auf dem deutschsprachigen Markt schließt. Dieses im englischsprachigen Raum bereits gut etablierte Buch führt auf grundlegende Weise an die Massenspektrometrie heran, indem es die Prinzipien, Methoden und Anwendungen logisch aufeinander aufbauend erklärt. Schritt für Schritt lernt der Leser, was diese analytische Methode leisten kann, auf welch vielfältige Art Massenspektrometer isolierte Ionen in der Gasphase erzeugen, selektieren und manipulieren können und wie man aus den resultierenden Massenspektren analytische Information gewinnt. Moderne sanfte Ionisationsmethoden wie ESI, APCI oder MALDI, klassische Verfahren wie EI, CI, FAB oder FD, Oberflächentechniken wie DESI oder DART und elementmassenspektrometrische Verfahren werden didaktisch durchdacht behandelt. Studienanfänger werden von dem Werk ebenso profitieren wie Fortgeschrittene und Praktiker. Ergänzend zum Buch betreibt der Autor eine frei zugängliche (englischsprachige) Internetseite mit zahlreichen Übungsaufgaben, Lösungen und Bonus-Material unter http://www.ms-textbook.com

Understanding Mass Spectra

A Basic Approach
Author: R. Martin Smith
Publisher: John Wiley & Sons
ISBN: 0471479349
Category: Science
Page: 372
View: 6312

Continue Reading →

Understanding Mass Spectra: A Basic Approach, Second Editioncombines coverage of the principles underlying mass spectralanalysis with clear guidelines on how to apply them in a laboratorysetting. Completely revised from the first edition, an updated andunified approach to mass spectral interpretation emphasizes theapplication of basic principles from undergraduate organic,analytical, and physical chemistry courses. A detailed overview of theory and instrumentation, this usefulguide contains step-by-step descriptions of interpretativestrategies and convenient lists and tables detailing theinformation needed to solve unknowns. Other features includereal-world case studies and examples, skill-building problems withclearly explained answers, and easy-to-follow explanations of theimportant mathematical derivations.

Interpretation of MS-MS Mass Spectra of Drugs and Pesticides


Author: Wilfried M. A. Niessen,Ricardo A. Correa C.
Publisher: John Wiley & Sons
ISBN: 1119294258
Category: Science
Page: 416
View: 7526

Continue Reading →

Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns

Introduction to Mass Spectrometry

Instrumentation, Applications, and Strategies for Data Interpretation
Author: J. Throck Watson,O. David Sparkman
Publisher: John Wiley & Sons
ISBN: 1118681584
Category: Science
Page: 864
View: 1630

Continue Reading →

Completely revised and updated, this text provides an easy-to-readguide to the concept of mass spectrometry and demonstrates itspotential and limitations. Written by internationally recognisedexperts and utilising "real life" examples of analyses andapplications, the book presents real cases of qualitative andquantitative applications of mass spectrometry. Unlike other massspectrometry texts, this comprehensive reference providessystematic descriptions of the various types of mass analysers andionisation, along with corresponding strategies for interpretationof data. The book concludes with a comprehensive 3000 references. This multi-disciplined text covers the fundamentals as well asrecent advance in this topic, providing need-to-know informationfor researchers in many disciplines including pharmaceutical,environmental and biomedical analysis who are utilizing massspectrometry

Mass Spectrometry

A Textbook
Author: Jürgen H Gross
Publisher: Springer Science & Business Media
ISBN: 354036756X
Category: Science
Page: 518
View: 6749

Continue Reading →

Mass Spectrometry is an ideal textbook for students and professionals as well as newcomers to the field. Starting from the very first principles of gas-phase ion chemistry and isotopic properties, the textbook takes the reader through the design of mass analyzers and ionization methods all the way to mass spectral interpretation and coupling techniques. Step-by-step, the reader learns how mass spectrometry works and what it can do. The book comprises a balanced mixture of practice-oriented information and theoretical background. It features a clear layout and a wealth of high-quality figures. Exercises and solutions are located on the Springer Global Web.

Gas Chromatography and Mass Spectrometry: A Practical Guide


Author: O. David Sparkman,Zelda Penton,Fulton G. Kitson
Publisher: Academic Press
ISBN: 9780080920153
Category: Science
Page: 632
View: 8471

Continue Reading →

The second edition of Gas Chromatography and Mass Spectrometry: A Practical Guide follows the highly successful first edition by F.G. Kitson, B.S. Larsen, and C.N. McEwen (1996), which was designed as an indispensible resource for GC/MS practitioners regardless of whether they are a novice or well experienced. The Fundamentals section has been extensively reworked from the original edition to give more depth of an understanding of the techniques and science involved with GC/MS. Even with this expansion, the original brevity and simple didactic style has been retained. Information on chromatographic peak deconvolution has been added along with a more in-depth understanding of the use of mass spectral databases in the identification of unknowns. Since the last edition, a number of advances in GC inlet systems and sample introduction techniques have occurred, and they are included in the new edition. Other updates include a discussion on fast GC and options for combining GC detectors with mass spectrometry. The section regarding GC Conditions, Derivatization, and Mass Spectral Interpretation of Specific Compound Types has the same number of compound types as the original edition, but the information in each section has been expanded to not only explain some of the spectra but to also explain why certain fragmentations take place. The number of Appendices has been increased from 12 to 17. The Appendix on Atomic Masses and Isotope Abundances has been expanded to provide tools to aid in determination of elemental composition from isotope peak intensity ratios. An appendix with examples on "Steps to follow in the determination of elemental compositions based on isotope peak intensities" has been added. Appendices on whether to use GC/MS or LC/MS, third-party software for use in data analysis, list of information required in reporting GC/MS data, X+1 and X+2 peak relative intensities based on the number of atoms of carbon in an ion, and list of available EI mass spectral databases have been added. Others such as the ones on derivatization, isotope peak patterns for ions with Cl and/or Br, terms used in GC and in mass spectrometry, and tips on setting up, maintaining and troubleshooting a GC/MS system have all been expanded and updated. Covers the practical instruction necessary for successful operation of GC/MS equipment Reviews the latest advances in instrumentation, ionization methods, and quantitation Includes troubleshooting techniques and a variety of additional information useful for the GC/MS practitioner A true benchtop reference A guide to a basic understanding of the components of a Gas Chromatograph-Mass Spectrometer (GC-MS) Quick References to data interpretation Ready source for information on new analyses

Mass Spectrometry Data Analysis in Proteomics


Author: Rune Matthiesen
Publisher: Springer Science & Business Media
ISBN: 1597452750
Category: Science
Page: 320
View: 3696

Continue Reading →

The intention of Mass Spectrometry Data Analysis in Proteomics is to support researchers in deciding which programs to use in various tasks related to analysis of mass spectrometry data in proteomics. The chapters give a precise description of the theoretical background of each topic followed accurate descriptions of programs and the parameters best suited for different cases.

Gas Chromatography and Mass Spectrometry

A Practical Guide
Author: Fulton G. Kitson,Barbara S. Larsen,Charles N. McEwen
Publisher: Academic Press
ISBN: 0080532322
Category: Science
Page: 381
View: 7825

Continue Reading →

This guide provides, under one cover, a wealth of practical information designed to facilitate the effectiveness of the GC/MS user. Separation conditions for numerous compound types are provided along with derivatized and underivatized compounds. A section on how to interpret mass spectral data, an extensive correlation of ion masses and neutral losses with possible structures, and examples of mass spectra are provided to further aid structure determination. Also included are basic information on instrumentation, ionization methods, quantitation, tips on the operation of mass spectrometers, the best derivatization procedures for a variety of compound types, troubleshooting techniques, and a variety of other information found to be useful to the practicing user of GC/MS instrumentation. This guide would be immediately valuable to the novice as well as the experienced GC/MS user who may not have the breadth of experience covered in this book. Key Features * Condenses and organizes recent and essential information for new and experienced GC/MS users * Comprehensively indexed and referenced * Includes practical methods of analysis * Serves as a text reference for short practical courses on the subject

A Beginner's Guide to Mass Spectral Interpretation


Author: Terrence A. Lee
Publisher: John Wiley & Sons
ISBN: 9780471976295
Category: Science
Page: 186
View: 6258

Continue Reading →

This book is a logical, step-by-step guide to identification oforganic compounds by mass spectrometry. The book is organized intochapters covering the major types of organic compounds, includingalcohols, acids and esters, aldehydes and ketones, ethers,hydrocarbons, halogenated compounds, amines and amides, andsulfur-containing compounds. In each chapter, the mechanisms of themajor fragmentation pathways are discussed, with reference toseveral simple sample compounds. By teaching the user to recognizetypical fragmentations, the book removes the need to searchdatabases, often limited, of electronic spectra. Key features ofthe book include: * 200 representative spectra of common organic compounds * Functional group approach to mass spectra interpretation * Appendix of 'unknown' spectra with step-by-step guide toidentification This book is a must for anyone who needs to identify organicmolecules by mass spectrometry but does not need to know thedetailed workings of a mass spectrometer.

Mass Spectrometry for Chemists and Biochemists


Author: Robert Alexander Walker Johnstone,Malcolm E. Rose
Publisher: Cambridge University Press
ISBN: 9780521424974
Category: Science
Page: 501
View: 7911

Continue Reading →

This book describes the full range of techniques and applications used in mass spectrometry. Researchers in universities and industry laboratories use this versatile technique because of its ability to identify a minute amount of material quickly. The technique solves analytical problems in a huge variety of fields. The authors adopt an instructional approach and make use of recent examples to illustrate important points. This second edition includes new methods and applications that have developed in the past ten years. The authors discuss powerful methods combining mass spectrometry with newer separation techniques, the increased use of computers, and analysis of once difficult polar and large-mass compounds such as proteins using new ionization methods. The book, requiring no previous knowledge of mass spectrometry, is an ideal teaching text at both the undergraduate and postgraduate level, and will also be of considerable interest to research workers.

Mass Spectrometry

Analytical Chemistry by Open Learning
Author: James Barker,David J. Ando,Reg Davis,Martin J. Frearson
Publisher: John Wiley & Sons
ISBN: 9780471967620
Category: Science
Page: 509
View: 9961

Continue Reading →

This thoroughly updated second edition of the ACOL text on Mass Spectrometry gives a modern approach to those beginning to use or study mass spectrometry. Self assessment questions and solutions are included. Fundamentals and modern instrumental techniques are also covered in this book.

Identification of Microorganisms by Mass Spectrometry


Author: Charles L. Wilkins,Jackson O. Lay
Publisher: John Wiley & Sons
ISBN: 0471748633
Category: Science
Page: 352
View: 515

Continue Reading →

A multidisciplinary approach to understanding the fundamentals ofmass spectrometry for bacterial analysis From chemotaxonomy to characterization of targeted proteins,Identification of Microorganisms by Mass Spectrometry provides anoverview of both well-established and cutting-edge massspectrometry techniques for identifying microorganisms. A vitaltool for microbiologists, health professionals, and analyticalchemists, the text is designed to help scientists select the mosteffective techniques for use in biomedical, biochemical,pharmaceutical, and bioterror defense applications. Since microbiological applications of mass spectrometry require abasic understanding of both microbiology and analytical chemistry,the editors have incorporated material from both disciplines sothat readers from either field will come to understand thenecessary principles of the other. Featuring contributions fromsome of the most recognized experts in both fields, this volumeprovides specific examples of fundamental methods as well asapproaches developed in the last decade, including: * Metastable atom bombardment pyrolysis mass spectrometry * Matrix-assisted laser desorption/ionization mass spectrometry(MALDI) * MALDI time-of-flight mass spectrometry (MALDI-TOF MS) of intactbacteria * High-resolution Fourier transform mass spectrometry (FTMS) * Electrospray ionization (ESI) mass spectrometry Identification of Microorganisms by Mass Spectrometry representsthe most comprehensive and up-to-date work on the topic currentlyavailable. It is liberally illustrated with figures and tables andcovers every aspect of spectrometric identification ofmicroorganisms, including experimental procedures, various means ofsample preparation, data analysis, and interpretation of complexmass spectral data.

Interpretation von Massenspektren


Author: Fred W. McLafferty,Frantisek Turecek
Publisher: Springer Spektrum
ISBN: 9783642398483
Category: Science
Page: 385
View: 3209

Continue Reading →

Die Interpretation von Massenspektren erlernt man am besten durch Praxis. Mit dieser Überzeugung hat McLafferty die Originalausgabe dieses Buches in mehrere erfolgreiche Auflagen geführt. Schritt für Schritt, anhand zahlreicher Beispiele, führt er den Leser zum Verständnis von Massenspektren und Massenspektrometrie. So schafft dieses Buch die Grundlage für das Verständnis und die optimale Nutzung einer Methode, die als eine der wichtigsten in der analytischen Chemie gilt.

Mass Spectrometry

Instrumentation, Interpretation, and Applications
Author: Agnieszka Kraj,Dominic M. Desiderio,Nico M. Nibbering
Publisher: John Wiley & Sons
ISBN: 047039580X
Category: Science
Page: 358
View: 2768

Continue Reading →

With contributions from noted experts from Europe and North America, Mass Spectrometry Instrumentation, Interpretation, and Applications serves as a forum to introduce students to the whole world of mass spectrometry and to the many different perspectives that each scientific field brings to its use. The book emphasizes the use of this important analytical technique in many different fields, including applications for organic and inorganic chemistry, forensic science, biotechnology, and many other areas. After describing the history of mass spectrometry, the book moves on to discuss instrumentation, theory, and basic applications.

Interpretation of Organic Spectra


Author: Yong-Cheng Ning
Publisher: John Wiley & Sons
ISBN: 0470828315
Category: Science
Page: 416
View: 2891

Continue Reading →

Although there are a number of books in this field, most of them lack an introduction of comprehensive analysis of MS and IR spectra, and others do not provide up-to-date information like tandem MS. This book fills the gap. The merit of this book is that the author will not only introduce knowledge for analyzing nuclear magnetic resonance spectra including 1H spectra (Chapter 1), 13C spectra (Chapter 2) and 2D NMR spectra (Chapter 3), he also arms readers systemically with knowledge of Mass spectra (including EI MS spectra and MS spectra by using soft ionizations) (Chapter 4) and IR spectra (Chapter 5). In each chapter the author presents very practical application skills by providing various challenging examples. The last chapter (Chapter 6) provides the strategy, skills and methods on how to identify an unknown compound through a combination of spectra. Based on nearly 40 years researching and teaching experience, the author also proposes some original and creative ideas, which are very practical for spectral interpretation.

Electrospray and MALDI Mass Spectrometry

Fundamentals, Instrumentation, Practicalities, and Biological Applications
Author: Richard B. Cole
Publisher: John Wiley & Sons
ISBN: 1118211553
Category: Science
Page: 847
View: 2415

Continue Reading →

Discover how advances in mass spectrometry are fueling newdiscoveries across a broad range of research areas Electrospray and MALDI Mass Spectrometry brings both veteranpractitioners and beginning scientists up to date with the mostrecent trends and findings in electrospray ionization andmatrix-assisted laser desorption/ionization (MALDI) massspectrometry. In particular, this Second Edition highlights howadvances in electrospray and MALDI mass spectrometry are supportingimportant discoveries in new and emerging fields such as proteomicsand metabolomics as well as in traditional areas of chemistry andphysics research. Electrospray AND MALDI Mass Spectrometry, SECOND EDITION isdivided into five parts: Part A, Fundamentals of ES, explains the fundamental phenomenaunderlying the electrospray process, including selectivity inionization and inherent electrochemistry, and concludes with achapter offering a comparative inventory of source hardware Part B, Fundamentals of MALDI, confronts ionization mechanisms,instrument development, and matrix selection, and includes a finalchapter that explores the special application of MALDI to obtaintwo-dimensional images of spatial distributions of compounds onsurfaces Part C, ES and MALDI Coupling to Mass SpectrometryInstrumentation, examines the coupling of these ionizationtechniques to various mass analyzers, including quadrupole iontrap, time-of-flight, Fourier transform ion cyclotron resonance,and ion mobility mass spectrometers Part D, Practical Aspects of ES and MALDI, investigatesanalytical issues including quantification, charge-statedistributions, noncovalent interactions in solution that arepreserved as gas-phase ions, and various means of ion excitation inpreparation for tandem mass spectrometry, and offers a guide to theinterpretation of even-electron mass spectra Part E, Biological Applications of ES and MALDI, examines therole of mass spectrometry in such areas as peptide and proteincharacterization, carbohydrate analysis, lipid analysis, and drugdiscovery Written by a team of leading experts, the book not only providesa critical review of the literature, but also presents key conceptsin tutorial fashion to help readers take full advantage of thelatest technological breakthroughs and applications. As a result,Electrospray and MALDI Mass Spectrometry will help researchersfully leverage the power of electrospray and MALDI massspectrometry. The judicious compartmentalization of chapters, andthe pedagogic presentation style throughout, render the book highlysuitable for use as a text for graduate-level courses in advancedmass spectrometry.