Handbook of Proteolytic Enzymes


Author: Alan J. Barrett,Neil D. Rawlings,J. Fred Woessner
Publisher: Academic Press
ISBN: 0123822203
Category: Science
Page: 4094
View: 4336

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The third edition of the Handbook of Proteolytic Enzymes is a comprehensive reference work for the enzymes that cleave proteins and peptides, written by acknowledged experts in the field and containing over 850 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features for a specific peptidase. There are also introductory chapters on peptidase classification and mechanisms and a comprehensive index. For the first time, the Handbook is also available online via Elsevier's ScienceDirect platform as well as a three-volume book. The online version has enhanced options, including online multimedia, cross-referencing capabilities, integrated online delivery and closer integration with the online MEROPS database of peptidases and their inhibitors. This reference work is a must-have for biochemists, biotechnologists, molecular biologists and students in these disciplines, and will be of great interest to pharmaceutical and biotechnology companies. Contains over 830 chapters Covers new research in therapeutics and drug trials Supplies content written by experts in the field

Industrial Enzymes

Structure, Function and Applications
Author: Julio Polaina,Andrew P. MacCabe
Publisher: Springer Science & Business Media
ISBN: 1402053770
Category: Science
Page: 641
View: 7558

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Recent developments in genetic engineering and protein chemistry are bringing ever more powerful means of analysis to bear on the study of enzyme structure. This volume reviews the most important types of industrial enzymes. In a balanced manner it covers three interrelated aspects of paramount importance for enzyme performance: three-dimensional protein structure, physicochemical and catalytic properties, and the range of both classical and novel applications.

Handbook of Industrial Drying


Author: Arun S. Mujumdar
Publisher: CRC Press
ISBN: 1420017616
Category: Technology & Engineering
Page: 1312
View: 9607

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Still the Most Complete, Up-To-Date, and Reliable Reference in the Field Drying is a highly energy-intensive operation and is encountered in nearly all industrial sectors. With rising energy costs and consumer demands for higher quality dried products, it is increasingly important to be aware of the latest developments in industrial drying technologies. For two decades, Mujumdar’s industry-standard Handbook of Industrial Drying has been the quintessential source of state-of-the-art information in the field, and this third edition is no exception. New in the Third Edition Covering everything from the fundamentals of drying to the latest dryer types, nearly two-thirds of this edition comprises new material at the vanguard of research and industrial practice. In addition to several rewritten and many more revised chapters, new chapters cover such topics as: Spreadsheet-aided dryer design Indirect and pneumatic drying Drying of fish and seafood, grain, herbal medicines, and tea Drying of nanosize products, enzymes, and textiles Dewatering and drying of wastewater treatment sludge Heat pump drying and industrial crystallization Solid–liquid separation for pretreatment Providing important data along with the experience, insight, and practical know-how contributed by experts from around the world, the Handbook of Industrial Drying, Third Edition remains the definitive reference to the complete spectrum of current and emerging industrial drying technologies.

Handbook of Seafood Quality, Safety and Health Applications


Author: Cesarettin Alasalvar,Kazuo Miyashita,Fereidoon Shahidi,Udaya Wanasundara
Publisher: John Wiley & Sons
ISBN: 9781444347760
Category: Technology & Engineering
Page: 576
View: 763

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The global market for seafood products continues to increase year by year. Food safety considerations are as crucial as ever in this sector, and higher standards of quality are demanded even as products are shipped greater distances around the world. The current global focus on the connection between diet and health drives growth in the industry and offers commercial opportunities on a number of fronts. There is great interest in the beneficial effects of marine functional compounds such as omega-3 polyunsaturated fatty acids. Seafoods are well-known as low calorie foods, and research continues into the nutritional effects on, for example, obesity and heart disease. In addition, by-products of marine food processing can be used in nutraceutical applications. This book is a resource for those interested in the latest advances in the science and technology of seafood quality and safety as well as new developments in the nutritional effects and applications of marine foods. It includes chapters on the practical evaluation of seafood quality; novel approaches in preservation techniques; flavour chemistry and analysis; textural quality and measurement; packaging; the control of food-borne pathogens and seafood toxins. New research on the health-related aspects of marine food intake are covered, as well as the use of seafoods as sources of bioactives and nutraceuticals. The book is directed at scientists and technologists in academia, government laboratories and the seafood industries, including quality managers, processors and sensory scientists.

Handbook of Industrial Chemistry and Biotechnology


Author: James A. Kent
Publisher: Springer Science & Business Media
ISBN: 1461442591
Category: Science
Page: 1562
View: 585

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Substantially revising and updating the classic reference in the field, this handbook offers a valuable overview and myriad details on current chemical processes, products, and practices. No other source offers as much data on the chemistry, engineering, economics, and infrastructure of the industry. The Handbook serves a spectrum of individuals, from those who are directly involved in the chemical industry to others in related industries and activities. It provides not only the underlying science and technology for important industry sectors, but also broad coverage of critical supporting topics. Industrial processes and products can be much enhanced through observing the tenets and applying the methodologies found in chapters on Green Engineering and Chemistry (specifically, biomass conversion), Practical Catalysis, and Environmental Measurements; as well as expanded treatment of Safety, chemistry plant security, and Emergency Preparedness. Understanding these factors allows them to be part of the total process and helps achieve optimum results in, for example, process development, review, and modification. Important topics in the energy field, namely nuclear, coal, natural gas, and petroleum, are covered in individual chapters. Other new chapters include energy conversion, energy storage, emerging nanoscience and technology. Updated sections include more material on biomass conversion, as well as three chapters covering biotechnology topics, namely, Industrial Biotechnology, Industrial Enzymes, and Industrial Production of Therapeutic Proteins.

Handbook of Synthetic Substrates


Author: H.C. Hemker
Publisher: Springer Science & Business Media
ISBN: 9400966903
Category: Medical
Page: 192
View: 3363

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The need for a handbook on the use of synthetic substrates for assay of proteases of the coagulation and fibrinolytic systems became evident several years ago during the activities of the Subcommittee on Synthetic Substrates of the International Committee on Thrombosis and Haemo stasis (lCTH). Production of such a handbook, which was recommended during discussions of the ICTH at its meeting in London in 1979 was made possible by the generous efforts of Professor HC Hemker with the aid of several contributors with particular interests in the use of synthetic substrates in coagulation and fibrinolysis. As current Chairman and Secretary General of the ICTH we would like to express our sincere thanks to Professor Hemker for producing this handbook and look for ward to seeing the benefits of this tremendous effort reflected in the advancement of our understanding of thrombosis and hemostasis and the transfer of such knowledge into improved diagnosis and treatment of thrombotic and hemorrhagic disorders. Craig M Jackson Professor of Biological Chemistry Washington University School of Medicine, St. Louis, MO Chairman, ICTH Harold R Roberts Professor of Internal Medicine University of North Carolina, Chapel Hill, NC Secretary General, ICTH ix Foreword The advent of synthetic substrates for the study of blood coagulation and fibrinolysis was a significant step forward in the investigation of these systems. Both basic research and clinical laboratory investigations can profit from these advanced tools.

Handbook of Immunochemistry


Author: Miroslav Ferencik
Publisher: Springer Science & Business Media
ISBN: 9401115524
Category: Science
Page: 519
View: 6824

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The book appeared in two previous Slovak editions for university students in Czechoslovakia. This edition presents a completely new version updated according to recent advances not only in immunochemistry and essential immunology but also in molecular biology, biochemistry and molecular genetics. The scope of the book is considerable since the goal was to cover the field of immunochemistry from the widest point of view including both the topic and methods of contemporary immunochemistry. Each chapter provides basic information on a specific subtopic, clearly and understandab ly, and presents principles of individual immunochemical methods. I am confident that the book will fill the gap between the books on essential immunology and highly specialised books on individual areas of immunoche mistry (e. g. on antibodies, antigens, numerous immunochemical techniques, etc. ). It may also prove useful for beginning investigators from different biological and medical fields as it supplies basic information needed for solving their scientific problems by immunochemical approaches. I do hope that readers will find the text stimulatory and pleasury to read. I wish to thank all colleagues and friends for supplying their own results, suggestions and for their encouraging comments. My thanks go also to the editors and publishers for their valuable contribution to the preparation of the book. 1 Introduction The term immunochemistry was coined by the Swedish chemist ARRHENIUS who used it for the first time in his lectures in 1907.

Handbook of Biologically Active Peptides


Author: Abba Kastin
Publisher: Academic Press
ISBN: 0123850967
Category: Science
Page: 2032
View: 1322

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Handbook of Biologically Active Peptides, Second Edition, is the definitive, indispensable reference for peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists. Its chapters are designed to be a source for workers in the field and enable researchers working in a specific area to examine related areas outside their expertise. Peptides play a crucial role in many physiological processes, including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The second edition of Handbook of Biologically Active Peptides presents this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. Presents all aspects of biologically active peptides in one resource Features more than 20 sections spanning plant, bacterial, fungal, venom, and invertebrate peptides to general peptides Includes immunological, inflammatory, cancer, vaccine, and neurotrophic peptides Discusses peptide precursors, mRNA distribution, processing, and receptors, not just pathophysiological implications

Handbook of Drug Interactions

A Clinical and Forensic Guide
Author: Ashraf Mozayani,Lionel Raymon
Publisher: Springer Science & Business Media
ISBN: 1592596541
Category: Medical
Page: 663
View: 1861

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A concise compilation of the known interactions of the most commonly prescribed drugs, as well as their interaction with nonprescription compounds. The agents covered include CNS drugs, cardiovascular drugs, antibiotics, and NSAIDs. For each class of drugs the authors review the pharmacology, pharmacodynamics, pharmacokinetics, chemistry, metabolism, epidemiological occurrences, adverse reactions, and significant interactions. Environmental and social pharmacological issues are also addressed in chapters on food and alcohol drug interactions, nicotine and tobacco, and anabolic doping agents. Comprehensive and easy-to-use, Handbook of Drug Interactions: A Clinical and Forensic Guide provides physicians with all the information needed to avoid prescribing drugs with undesirable interactions, and toxicologists with all the data necessary to interpret possible interactions between drugs found simultaneously in patient samples.

Handbook of Fermented Meat and Poultry


Author: Fidel Toldrá
Publisher: John Wiley & Sons
ISBN: 1118522672
Category: Technology & Engineering
Page: 528
View: 6539

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Fermented meat products have been consumed for centuries in many different parts of the world and constitute one of the most important groups of food. Bacterial cultures are used in their manufacture to preserve the meat and confer particular textures and sensory attributes. Examples of fermented meats include salami, chorizo, pepperoni and saucisson. This fully revised and expanded reference book on meat fermentation presents all the principle fermented meat products and the processing technologies currently used in their manufacture. The 54 chapters of this substantial book are grouped into the following sections: Meat fermentation worldwide: overview, production and principles Raw materials Microbiology and starter cultures for meat fermentation Sensory attributes Product categories: general considerations Semidry-fermented sausages Dry-fermented sausages Other fermented meats and poultry Ripened meat products Biological and chemical safety of fermented meat products Processing sanitation and quality assurance There are five new chapters in the second edition that address the following topics: Smoking and new smoke flavourings; Probiotics; Methodologies for the study of the microbial ecology in fermented sausages; Low sodium in meat products; and Asian sausages. Handbook of Fermented Meat and Poultry, Second Edition provides readers with a full overview of meat fermentation, the role of microorganisms naturally present and/or added as starter cultures, safety aspects and an account of the main chemical, biochemical, physical and microbiological changes that occur in processing and how they affect final quality. Finally, readers will find the main types of worldwide fermented meat products, typically produced in different areas, with the description of their main characteristics.

Handbook of Venoms and Toxins of Reptiles


Author: Stephen P. Mackessy
Publisher: CRC Press
ISBN: 9781420008661
Category: Nature
Page: 528
View: 5328

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The Handbook of Venoms and Toxins of Reptiles offers "one-stop shopping" to all biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation. This book examines the topic generally, provides an overview of the current taxonomy of these reptiles, explains the similarities and differences in the venom delivery apparatus in different groups of reptiles, reviews state-of-the-art knowledge about specific venom components and their action, and summarizes effects of envenomation and treatment in humans on different continents. Produced by leading toxinologists, biologists, biochemists, and physicians from 12 countries, the book provides a broad, international perspective that bridges divergent areas in modern biology. A synthesis of current knowledge about venoms and venomous reptiles, it contains a wealth of illustrations, including an 8-page color insert, that present a view of reptile toxinology from the whole animal to the glands producing venoms to the molecular models and the mechanisms of actions of the toxins themselves. The book provides a context for understanding the range of activities present in venoms and supplies detailed information on many enzymes and toxins found in them, bringing into focus the worldwide extent of the occurrence and complexity of human envenomations by reptiles. It explores the unique and interesting results produced by collaborations between specialists from very different fields and how they can stimulate new and continued interest in research on venoms and the animals that produce them.

Rheumatology E-Book


Author: Marc C. Hochberg,Alan J. Silman,Josef S. Smolen,Michael E. Weinblatt,Michael H. Weisman
Publisher: Elsevier Health Sciences
ISBN: 0702063037
Category: Medical
Page: 2112
View: 2420

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Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg’s Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics. Remain up to date on the latest information in rheumatology through 13 brand-new chapters covering biomedical and translation science, disease and outcome assessment, new imaging modalities, early emerging disease, clinical therapeutics, patient management, and rehabilitation. Take advantage of expanded coverage of small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies. Focus on the core knowledge needed for successful results with each chapter co-authored by an internationally-renowned specialist in the field. Easily find the information you need thanks to a consistent, user-friendly format with templated content and large-scale images.

Perspectives in Molecular Toxinology


Author: A. Ménez
Publisher: John Wiley & Sons
ISBN: 9780471495031
Category: Medical
Page: 485
View: 4657

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In this volume the editors have reviewed the most recent major advances in our understanding of toxins from venomous animals and microbes and their targets in mammals, insects and other animals. To approach these challenging aspects, the authors have posed crystal-clear questions based on the most precise acquired knowledge. * What can be learnt from genomics and proteomics? * What are the intimate modes of action of toxins on ion channels, receptors, enzymes, cell membranes? * What is the molecular basis of specificity and more generally of pleiotropism of toxins? * What else can be learnt about toxin tertiary structures and dynamics? * How can we enhance our understanding of target architecture and complex toxin-target structures? * Are toxins subject to accelerated evolution? * Can they be exploited as models for the design of new drugs? * What does the future hold for the treatment of snake bites? These are just some of the many questions that have been addressed in this book. Complete answers may not always be readily apparent, but the attendant reasoning shows how toxinology has become an important area of biochemistry, directly associated with advances in cellular microbiology, molecular pharmacology, molecular physiology, cell biology, protein engineering, and other disciplines.

Handbook of Dairy Foods Analysis


Author: Leo M.L. Nollet,Fidel Toldra
Publisher: CRC Press
ISBN: 1420046314
Category: Technology & Engineering
Page: 918
View: 5591

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Dairy foods account for a large portion of the Western diet, but due to the potential diversity of their sources, this food group often poses a challenge for food scientists and their research efforts. Bringing together the foremost minds in dairy research, Handbook of Dairy Foods Analysis compiles the top dairy analysis techniques and methodologies from around the world into one, well-organized volume. Co-Edited by Fidel Toldra - Recipient of the 2010 Distinguished Research Award from the American Meat Science Association Exceptionally comprehensive both in its detailing of methods and the range of products covered, this handbook includes tools for analyzing chemical and biochemical compounds and also bioactive peptides, prebiotics, and probiotics. It describes noninvasive chemical and physical sensors and starter cultures used in quality control. Covers the Gamut of Dairy Analysis Techniques The book discusses current methods for the detection of microorganisms, allergens, and other adulterations, including those of environmental origin or introduced during processing. Other methodologies used to evaluate color, texture, and flavor are also discussed. Written by an International Panel of Distinguished Contributors Under the editorial guidance of renowned authorities, Leo M.L. Nollet and Fidel Toldrá, this handbook is one of the few references that is completely devoted to dairy food analysis – a extremely valuable reference for those in the dairy research, processing, and manufacturing industries.

Handbook of ICU Therapy


Author: John Fuller,Jeff Granton,Ian McConachie
Publisher: Cambridge University Press
ISBN: 110764190X
Category: Medical
Page: 484
View: 5479

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A concise and practical summary of principles of therapy for critically ill patients, fully updated with thirteen new chapters.

Developmental Biology of Neoplastic Growth


Author: Alvaro Macieira-Coelho
Publisher: Springer Science & Business Media
ISBN: 9783540250098
Category: Medical
Page: 253
View: 4484

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Perceiving tumour growth as a deviation from the normal development of the human organism, this book discusses the molecular, cellular, and tissue determinants of different tumours, showing that each is a different disease, often corresponding to a particular developmental stage. It explains the distribution of cancers during the human life span.

Handbook of the Vulnerable Plaque


Author: Ron Waksman,Patrick W. Serruys,Johannes Schaar
Publisher: CRC Press
ISBN: 9781439804537
Category: Medical
Page: 424
View: 6094

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Since publication of the First Edition, advances in the diagnosis and prevention and treatment strategies of the vulnerable plaque have necessitated this greatly expanded second edition. With several new chapters covering mainly diagnostic and treatment options, The Handbook of the Vulnerable Plaque will remain the benchmark text for all interventional cardiologists treating vulnerable patients by providing the physician with comprehensive insight into the world of the vulnerable plaque.

CRC Handbook of Dietary Fiber in Human Nutrition, Third Edition


Author: Gene A. Spiller
Publisher: CRC Press
ISBN: 1420038516
Category: Medical
Page: 736
View: 3879

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Dietary fiber is widely recognized as an essential element of good nutrition. In fact, research on the use of fiber in food science and medicine is being conducted at an incredible pace. CRC Handbook of Dietary Fiber in Human Nutrition, Third Edition explores the chemistry, analytical methodologies, physiological and biochemical aspects, clinical and epidemiological studies, and consumption patterns of dietary fiber. Featuring new chapters and tables, in addition to updated sections, the third edition of this popular book includes important information that has become available since the publication of the second edition. What's new in the Third Edition? o Definitions and consumption of dietary fiber from 1992-2000 o A new chapter on the physical chemistry of dietary fiber o Updated dietary fiber values for common foods o New table: Tartaric Acid Content of Foods o Coverage of non-plant food fibers, such as chitin and chitosan o An entire section devoted to the effect of whole grains, cereal fiber, and phytic acid on health o Discussion of the interaction of fiber and phytochemicals Quickly retrieve and understand current data with the book's concise, easy-to-read tables and definitions. Covering all aspects of dietary fiber, including chemistry and definitions, analytical procedures, and basic physiological functions, the CRC Handbook of Dietary Fiber in Human Nutrition provides you with a unique collection of dietary fiber information unlike that found in any other book.

Cytokines and Joint Injury


Author: Wim B. van den Berg,Pierre Miossec
Publisher: Springer
ISBN: 3034878834
Category: Medical
Page: 296
View: 9580

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The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevance for better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of old and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Spe cial attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. In addition to an outline of the role of established cytokines, such as TNF, IL-l and IL-6, new information is given on the novel cytokines IL-15, IL-17 and IL-18 and their positioning in the complex cytokine interplay. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. Together, the chapters provide a complete and balanced view on pivotal cytokines and joint pathology.