Handbook of Pharmacogenomics and Stratified Medicine

Author: N.A
Publisher: Academic Press
ISBN: 0123868831
Category: Science
Page: 1118
View: 2458

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Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

Handbook of Personalized Medicine

Advances in Nanotechnology, Drug Delivery, and Therapy
Author: Ioannis S. Vizirianakis
Publisher: CRC Press
ISBN: 9814411205
Category: Medical
Page: 1560
View: 1346

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This book compiles multidisciplinary efforts to conceptualize the environment in research and clinical setting that creates the fertile ground for the practical utility of personalized medicine decisions and also enables clinical pharmacogenomics for establishing pharmacotyping in drug prescription. Its covers innovative drug formulations and nanotheranostics, molecular imaging and signatures, translational nanomedicine and informatics, stem cell therapy approaches, modeling and predictability of drug response, pharmacogenetics-guided drug prescription, pediatric drug dosing, pharmacovigilance and regulatory aspects, ethical and cost-effectiveness issues, pharmacogenomics knowledge bases, personal genome sequencing, molecular diagnostics, as well as information-based medicine.

Routledge Handbook of Medical Law and Ethics

Author: Yann Joly,Bartha Maria Knoppers
Publisher: Routledge
ISBN: 1134448651
Category: Law
Page: 480
View: 656

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This book explores the scope, application and role of medical law, regulatory norms and ethics, and addresses key challenges introduced by contemporary advances in biomedical research and healthcare. While mindful of national developments, the handbook supports a global perspective in its approach to medical law. Contributors include leading scholars in both medical law and ethics, who have developed specially commissioned pieces in order to present a critical overview and analysis of the current state of medical law and ethics. Each chapter offers comprehensive coverage of longstanding and traditional topics in medical law and ethics, and provides dynamic insights into contemporary and emerging issues in this heavily debated field. Topics covered include: Bioethics, health and human rights Medical liability Law and emerging health technologies Public health law Personalized medicine The law and ethics of access to medicines in developing countries Medical research in the genome era Emerging legal and ethical issues in reproductive technologies This advanced level reference work will prove invaluable to legal practitioners, scholars, students and researchers in the disciplines of law, medicine, genetics, dentistry, theology, and medical ethics.

World Scientific Handbook Of Global Health Economics And Public Policy (A 3-volume Set)

Author: Scheffler Richard M
Publisher: World Scientific
ISBN: 9814612332
Category: Health & Fitness
Page: 1628
View: 2780

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This Handbook covers major topics in global health economics and public policy and provides a timely, systematic review of the field. Edited by Richard M Scheffler, Distinguished Professor of Health Economics and Public Policy and Director of the Global Center for Health Economics and Policy Research at the University of California, Berkeley, the Handbook features academics and practitioners from more than a dozen countries. Contributors are from the London School of Economics and Political Science, Pompeu Fabra University in Barcelona, University of York, University of Oslo, London School of Hygiene and Tropical Medicine, University of California - Berkeley, Stanford University, Johns Hopkins University, University of Toronto, University of Oxford, Harvard Medical School, OECD, the World Health Organization and the World Bank, many of whom have also acted as economic and policy advisors to government and non-governmental organizations across the world. Experts in these areas who provide critical analyses and relevant data for further exploration and research include: Thomas E Getzen, Executive Director of the International Health Economics Association (iHEA); Douglas E Hough, Associate Scientist and Associate Director of the Master in Healthcare Management programme at the Bloomberg School of Public Health of John Hopkins University; Guillem López-Casasnovas, former President of iHEA and member of the Advisory Council of the Spanish Health and Social Welfare Ministry and of the Advisory Council of the Catalan Health Ministry since 1984; Alistair McGuire, Professor of Health Economics at the London School of Economics and Political and advisor to a number of governments and governmental bodies across Europe; Tor Iversen, Research Director at the Health Economics Research Programme at the University of Oslo and former member of the iHEA Arrow Award Committee 2007-2011; William H Dow, Professor and Associate Dean for Research at University of California ,Berkeley and former Senior Economist for the Council of Economic Advisors (White House); Audrey Laporte, the Director of the Canadian Centre for Health Economics; Alexander S Preker, President and CEO of Health Investment & Financing Corporation; Ayda Yurekli, who initiated and developed the World Health Organization TaXSiM simulation model that has been used by many Ministries of Finance around the world for the development of tax policies; Marko Vujicic, Managing Vice President of the Health Policy Resources Center at the American Dental Association; Mark Sculpher, Director of the Programme on Economic Evaluation and Health Technology Assessment at the University of York and former President of the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) (2011-2012); and Peter Berman, who has had almost 40 years of experience in global health and was formerly a Lead Health Economist at the World Bank. The Handbook spans across three volumes. The chapters deal with key global issues in health economics, are evidence-based, and offer innovative policy alternatives and solutions. The Handbook's approach toward global health economics and public policy will make it a useful resource for health economists, policymakers, private sector companies, NGOs, government decision-makers and those who manage healthcare systems.

Handbook of Pharmaceutical Biotechnology

Author: Shayne C. Gad
Publisher: Wiley-Interscience
Category: Medical
Page: 1659
View: 1862

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Describes the use of biotechnology to develop pharmaceuticals. This book gives the professional a basic tool to facilitate the development of biotech medicines by bringing together a general overview of biotechnology used in the drug development process, along with a compendium of regulations and validation methods.

Handbook of Psoriasis and Psoriatic Arthritis

Author: Richard Warren,Alan Menter
Publisher: Springer
ISBN: 3319182277
Category: Medical
Page: 116
View: 6143

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This concise handbook looks at psoriasis and psoriatic arthritis as separate but often related conditions, focusing on a background around the indications, such as disease overview and epidemiology; going on to look at the etiology and immunopathogenesis of each indication; looking at the clinical presentation and diagnosis; before focusing on the current and emerging treatment options, including a brief section on the issues of quality of life and comorbidities associated with these indications. ​

Der Experimentator: Molekularbiologie / Genomics

Author: Cornel Mülhardt
Publisher: Spektrum Akademischer Verlag
ISBN: 9783827420367
Category: Science
Page: 316
View: 6935

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Dieses überaus erfolgreiche Laborhandbuch präsentiert das Grundlagenwissen sowie Tipps und Tricks für den Umgang mit Nucleinsäuren. Es richtet sich an alle Experimentatoren, die molekularbiologische Versuche durchführen wollen und gern nachvollziehen möchten, was sich in ihrem Reaktionsgefäß abspielt. Das ganze Spektrum der üblichen molekularbiologischen Methoden wird vorgestellt, kommentiert und Alternativen aufgezeigt. Am Ende findet sich auch noch ein Kapitel zur Karriereplanung.

Molekulare Humangenetik

Author: Tom Strachan,Andrew P. Read
Publisher: Spektrum Akademischer Verlag
ISBN: 9783827414939
Category: Science
Page: 802
View: 7288

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Die vorliegende 3. Auflage der Molekularen Humangenetik ist völlig neu überarbeitet - unter Berücksichtigung der Entdeckungen, die im Zuge und in der Folge des Human Genome Project gemacht wurden. Die einführenden Kapitel (Teil I) beschreiben die Grundlagen wie DNA-Struktur und -Funktion, Chromosomen, Zellen und Entwicklung, Stammbaumanalysen und grundlegende Techniken im Labor. In Teil II werden die verschiedenen Genomsequenzierungsprojekte und die dadurch ermöglichten Einblicke in Organisation, Expression, Variabilität und Evolution des menschlichen Genoms gezeigt. Die Kartierung, Identifizierung und Diagnose der Ursachen von mendelnden und komplexen Krankheiten sowie Krebs ist Schwerpunkt von Teil III. Der letzte Teil gibt Ausblicke auf die funktionelle Genomik und Bioinformatik, auf Tiermodelle und Therapien. Das Buch soll eine Brücke bilden zwischen den grundlegenden Lehrbüchern und der Forschungsliteratur, sodass auch Interessierte mit relativ wenig Hintergrundwissen zum Thema die neuesten Forschungsergebnisse lesen und beurteilen können.

Health technology assessment

Konzepte, Methoden, Praxis für Wissenschaft und Entscheidungsfindung
Author: Matthias Perleth,Reinhard Busse
Publisher: MWV
ISBN: 3939069221
Category: Medical
Page: 259
View: 2406

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höhenbedingte Erkrankungen und Gesundheitsgefahren bei Bergsteigern
Author: Andrew J. Pollard,David R. Murdoch
Publisher: N.A
ISBN: 9783456844435
Page: 199
View: 2207

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Das Buch des Lebens

wer schrieb den genetischen Code?
Author: Lily E. Kay
Publisher: N.A
ISBN: 9783518293461
Category: Genetic code
Page: 556
View: 3425

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Freie Liebe und andere Geschichten

Author: Ali Smith
Publisher: btb Verlag
ISBN: 3641199654
Category: Fiction
Page: 160
View: 8473

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Ein Mädchen entdeckt im Rotlichtviertel von Amsterdam ganz unerwartet das berauschende Gefühl sexueller Freiheit. Eine Kinokartenabreißerin träumt sich aus ihrem Leben heraus und in die unbegrenzten Möglichkeiten der Filme hinein. Ein Fotograf besucht seine alte schottische Heimat und lernt von einer Neunjährigen, auf Dächer zu klettern und Steine übers Wasser springen zu lassen ... Unbändige Lebenslust spricht aus den Erzählungen der schottischen Autorin Ali Smith, die Freude an der Entdeckung der Welt, die Begeisterung über Worte und ihre Kraft, der Rausch des Aufbruchs und der erwachenden Sehnsucht, das unglaubliche Glücksgefühl, Liebe zu finden. Und wie gut es ist, eine Frau zu sein.

Verwaltete Körper

Strategien der Gesundheitspolitik im internationalen Vergleich
Author: Herbert Gottweis
Publisher: Böhlau Verlag Wien
ISBN: 9783205771135
Category: Medical policy
Page: 376
View: 8350

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