Handbook of Pharmacogenomics and Stratified Medicine


Author: N.A
Publisher: Academic Press
ISBN: 0123868831
Category: Science
Page: 1118
View: 2118

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Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

Textbook of Cultural Psychiatry


Author: Dinesh Bhugra,Kamaldeep Bhui
Publisher: Cambridge University Press
ISBN: 1108683169
Category: Medical
Page: N.A
View: 7898

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Cultural psychiatry deals with the impact of culture on causation, perpetuation and treatment of patients suffering with mental illness. The role of culture in mental illness is increasingly being recognised, and the misconceptions that can occur as a result of cultural differences can lead to misdiagnoses, under or over-diagnosis. This second edition of the Textbook of Cultural Psychiatry has been completely updated with additional new chapters on globalisation and mental health, social media and tele-psychiatry. Written by world-leading experts in the field, this new edition provides a framework for the provision of mental health care in an increasingly globalised world. The first edition of the Textbook of Cultural Psychiatry was commended in the BMA Book Awards in 2008 and was the recipient of the 2012 Creative Scholarship Award from the Society for the Study of Psychiatry and Culture.

Handbook of Personalized Medicine

Advances in Nanotechnology, Drug Delivery, and Therapy
Author: Ioannis S. Vizirianakis
Publisher: CRC Press
ISBN: 9814411205
Category: Medical
Page: 1560
View: 6989

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This book compiles multidisciplinary efforts to conceptualize the environment in research and clinical setting that creates the fertile ground for the practical utility of personalized medicine decisions and also enables clinical pharmacogenomics for establishing pharmacotyping in drug prescription. Its covers innovative drug formulations and nanotheranostics, molecular imaging and signatures, translational nanomedicine and informatics, stem cell therapy approaches, modeling and predictability of drug response, pharmacogenetics-guided drug prescription, pediatric drug dosing, pharmacovigilance and regulatory aspects, ethical and cost-effectiveness issues, pharmacogenomics knowledge bases, personal genome sequencing, molecular diagnostics, as well as information-based medicine.

Routledge Handbook of Medical Law and Ethics


Author: Yann Joly,Bartha Maria Knoppers
Publisher: Routledge
ISBN: 1134448651
Category: Law
Page: 480
View: 4889

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This book explores the scope, application and role of medical law, regulatory norms and ethics, and addresses key challenges introduced by contemporary advances in biomedical research and healthcare. While mindful of national developments, the handbook supports a global perspective in its approach to medical law. Contributors include leading scholars in both medical law and ethics, who have developed specially commissioned pieces in order to present a critical overview and analysis of the current state of medical law and ethics. Each chapter offers comprehensive coverage of longstanding and traditional topics in medical law and ethics, and provides dynamic insights into contemporary and emerging issues in this heavily debated field. Topics covered include: Bioethics, health and human rights Medical liability Law and emerging health technologies Public health law Personalized medicine The law and ethics of access to medicines in developing countries Medical research in the genome era Emerging legal and ethical issues in reproductive technologies This advanced level reference work will prove invaluable to legal practitioners, scholars, students and researchers in the disciplines of law, medicine, genetics, dentistry, theology, and medical ethics.

World Scientific Handbook Of Global Health Economics And Public Policy (A 3-volume Set)


Author: Scheffler Richard M
Publisher: World Scientific
ISBN: 9814612332
Category: Health & Fitness
Page: 1628
View: 9285

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This Handbook covers major topics in global health economics and public policy and provides a timely, systematic review of the field. Edited by Richard M Scheffler, Distinguished Professor of Health Economics and Public Policy and Director of the Global Center for Health Economics and Policy Research at the University of California, Berkeley, the Handbook features academics and practitioners from more than a dozen countries. Contributors are from the London School of Economics and Political Science, Pompeu Fabra University in Barcelona, University of York, University of Oslo, London School of Hygiene and Tropical Medicine, University of California - Berkeley, Stanford University, Johns Hopkins University, University of Toronto, University of Oxford, Harvard Medical School, OECD, the World Health Organization and the World Bank, many of whom have also acted as economic and policy advisors to government and non-governmental organizations across the world. Experts in these areas who provide critical analyses and relevant data for further exploration and research include: Thomas E Getzen, Executive Director of the International Health Economics Association (iHEA); Douglas E Hough, Associate Scientist and Associate Director of the Master in Healthcare Management programme at the Bloomberg School of Public Health of John Hopkins University; Guillem López-Casasnovas, former President of iHEA and member of the Advisory Council of the Spanish Health and Social Welfare Ministry and of the Advisory Council of the Catalan Health Ministry since 1984; Alistair McGuire, Professor of Health Economics at the London School of Economics and Political and advisor to a number of governments and governmental bodies across Europe; Tor Iversen, Research Director at the Health Economics Research Programme at the University of Oslo and former member of the iHEA Arrow Award Committee 2007-2011; William H Dow, Professor and Associate Dean for Research at University of California ,Berkeley and former Senior Economist for the Council of Economic Advisors (White House); Audrey Laporte, the Director of the Canadian Centre for Health Economics; Alexander S Preker, President and CEO of Health Investment & Financing Corporation; Ayda Yurekli, who initiated and developed the World Health Organization TaXSiM simulation model that has been used by many Ministries of Finance around the world for the development of tax policies; Marko Vujicic, Managing Vice President of the Health Policy Resources Center at the American Dental Association; Mark Sculpher, Director of the Programme on Economic Evaluation and Health Technology Assessment at the University of York and former President of the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) (2011-2012); and Peter Berman, who has had almost 40 years of experience in global health and was formerly a Lead Health Economist at the World Bank. The Handbook spans across three volumes. The chapters deal with key global issues in health economics, are evidence-based, and offer innovative policy alternatives and solutions. The Handbook's approach toward global health economics and public policy will make it a useful resource for health economists, policymakers, private sector companies, NGOs, government decision-makers and those who manage healthcare systems.

Omics for Personalized Medicine


Author: Debmalya Barh,Dipali Dhawan,Nirmal Kumar Ganguly
Publisher: Springer Science & Business Media
ISBN: 8132211847
Category: Medical
Page: 832
View: 5055

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“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

Handbook of Anxiety and Fear


Author: D. Caroline Blanchard,Guy Griebel,David J Nutt
Publisher: Elsevier
ISBN: 9780080559520
Category: Psychology
Page: 450
View: 4020

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This Handbook brings together and integrates comprehensively the core approaches to fear and anxiety. Its four sections: Animal models; neural systems; pharmacology; and clinical approaches, provide a range of perspectives that interact to produce new light on these important and sometimes dysfunctional emotions. Fear and anxiety are analyzed as patterns that have evolved on the basis of their adaptive functioning in response to threat. These patterns are stringently selected, providing a close fit with environmental situations and events; they are highly conservative across mammalian species, producing important similarities, along with some systematic differences, in their human expression in comparison to that of nonhuman mammals. These patterns are described, with attention to both adaptive and maladaptive components, and related to new understanding of neuroanatomic, neurotransmitter, and genetic mechanisms. Although chapters in the volume acknowledge important differences in views of fear and anxiety stemming from animal vs. human research, the emphasis of the volume is on a search for an integrated view that will facilitate the use of animal models of anxiety to predict drug response in people; on new technologies that will enable direct evaluation of biological mechanisms in anxiety disorders; and on strengthening the analysis of anxiety disorders as biological phenomena. • Integrates animal and human research on fear and anxiety • Presents emerging and developing fields of human anxiety research including imaging of anxiety disorders, the genetics of anxiety, the pharmacology of anxiolysis, recent developments in classification of anxiety disorders, linking these to animal work • Covers basic research on innate and conditioned responses to threat • Presents work from the major laboratories, on fear learning and extinction • Reviews research on an array of neurotransmitter and neuromodulator systems related to fear and anxiety • Compares models, and neural systems for learned versus unlearned responses to threat • Relates the findings to the study, diagnostics, and treatment of anxiety disorders, the major source of mental illness in modern society (26 % of Americans are affected by anxiety disorders!)

The SAGE Handbook of Health Care Ethics


Author: Ruth Chadwick,Henk ten Have,Eric M. Meslin
Publisher: SAGE
ISBN: 144620961X
Category: Medical
Page: 480
View: 7304

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The SAGE Handbook of Health Care Ethics is an influential collection of work by leading scholars on the fundamental and emerging themes which define health care ethics. Combining international and interdisciplinary perspectives, the Handbook provides a cutting-edge account of debates in five key areas: - health care ethics in an era of globalization - beginning and end-of-life - vulnerable populations - research ethics and technologies - public health and human rights. This authoritative Handbook brings together experts with backgrounds in philosophy, sociology, law, public policy and the health professions and reflects the increasing impact of globalisation and the dynamic advances in the fields of bioscience and genetics, which keep ethics at the centre of debates about the future direction of healthcare. It is an invaluable resource for all students, practitioners, academics and researchers investigating ethical issues in relation to healthcare.

Textbook of Anxiety Disorders


Author: Dan J. Stein,Eric Hollander,Barbara O. Rothbaum
Publisher: American Psychiatric Pub
ISBN: 1585629006
Category: Medical
Page: 822
View: 7422

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Acclaimed as "a tremendous contribution to the field of psychiatry" (Doody's Health Science Book Review Journal), the Textbook of Anxiety Disorders is now available in an expanded second edition. The new edition continues to offer both clinicians and researchers a single-volume resource that covers not only progress in clinical interventions but also the latest advances in theoretical knowledge. Following a comprehensive overview of anxiety disorders, the book provides detailed coverage of seven specific DSM-IV-TR diagnoses: generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), mixed anxiety-depression, panic disorder, social phobia, specific phobias, and posttraumatic stress disorder (PTSD). Each section covers the latest thinking on symptomatology and pathogenesis, then provides evidence-based clinical recommendations for pharmacotherapy and psychotherapy. All chapters have been expanded and fully updated with new research findings. Many chapters have been entirely rewritten by new authors to provide fresh insight into such topics as integrated treatment of anxiety disorders; pharmacotherapy for GAD, OCD, and panic disorder; psychotherapy for OCD and PTSD; anxiety disorders in the elderly; anxiety accompanying substance abuse; and the economic and social costs of anxiety. In addition, new chapters on anxious traits and temperaments, the neuropsychology of anxiety disorders, and anxiety and insomnia enhance this comprehensive edition. Each chapter now includes a concise summary of key clinical points that helps readers put findings into practice -- as well as recommended readings that provide access to essential reports. Standing at the cutting edge of anxiety disorder research and clinical practice, this authoritative volume deserves a place on the reference shelf of any busy clinician, researcher, or educator. It will be invaluable to all mental health care professionals interested in the latest developments in understanding and treating these complex and costly disorders.

Handbook of Decision Analysis


Author: Gregory S. Parnell, PhD,Terry Bresnick, MBA,Steven N. Tani, PhD,Eric R. Johnson, PhD
Publisher: John Wiley & Sons
ISBN: 1118515846
Category: Business & Economics
Page: 432
View: 2601

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A ONE-OF-A-KIND GUIDE TO THE BEST PRACTICES IN DECISION ANALYSIS Decision analysis provides powerful tools for addressing complex decisions that involve uncertainty and multiple objectives, yet most training materials on the subject overlook the soft skills that are essential for success in the field. This unique resource fills this gap in the decision analysis literature and features both soft personal/interpersonal skills and the hard technical skills involving mathematics and modeling. Readers will learn how to identify and overcome the numerous challenges of decision making, choose the appropriate decision process, lead and manage teams, and create value for their organization. Performing modeling analysis, assessing risk, and implementing decisions are also addressed throughout. Additional features include: Key insights gleaned from decision analysis applications and behavioral decision analysis research Integrated coverage of the techniques of single- and multiple-objective decision analysis Multiple qualitative and quantitative techniques presented for each key decision analysis task Three substantive real-world case studies illustrating diverse strategies for dealing with the challenges of decision making Extensive references for mathematical proofs and advanced topics The Handbook of Decision Analysis is an essential reference for academics and practitioners in various fields including business, operations research, engineering, and science. The book also serves as a supplement for courses at the upper-undergraduate and graduate levels.

Clinical Trials

Study Design, Endpoints and Biomarkers, Drug Safety, and FDA and ICH Guidelines
Author: Tom Brody
Publisher: Academic Press
ISBN: 0128042583
Category: Medical
Page: 896
View: 3601

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Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials. Contains new and fully revised material on key topics such as biostatistics, biomarkers, orphan drugs, biosimilars, drug regulations in Europe, drug safety, regulatory approval and more Extensively covers the "study schema" and related features of study design Incorporates laboratory data from studies on human patients to provide a concrete tool for understanding the concepts in the design and conduct of clinical trials Includes decisions made by FDA reviewers when granting approval of a drug as real world learning examples for readers

Handbook of Psoriasis and Psoriatic Arthritis


Author: Richard Warren,Alan Menter
Publisher: Springer
ISBN: 3319182277
Category: Medical
Page: 116
View: 8690

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This concise handbook looks at psoriasis and psoriatic arthritis as separate but often related conditions, focusing on a background around the indications, such as disease overview and epidemiology; going on to look at the etiology and immunopathogenesis of each indication; looking at the clinical presentation and diagnosis; before focusing on the current and emerging treatment options, including a brief section on the issues of quality of life and comorbidities associated with these indications. ​

Handbook of Pharmacogenetics


Author: Sean Boyd
Publisher: N.A
ISBN: 9781632422118
Category: Medical
Page: 306
View: 4538

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This book offers expertly selected information to the readers regarding the field of Pharmacogenetics. The main purpose of the fast developing field of Pharmacogenetics is to identify the genetic factors responsible for the inter-individual variation of drug reaction. These factors make it convenient to classify the patients according to their treatment needs and hence, catalyze drug development and encourage customized, secure and effective treatments. This book provides a wide range of examples discussing various drugs for distinct diseases which reflect different stages of assessment and application. This book is comprehensive and a great source of information to scientists, professionals, practitioners and students alike, since it discusses not just the fundamentals of pharmacogenetics but also focuses on the applications of pharmacogenetics and latest developments in this field along with discussion on its limitations and proposal of ideas to overcome them.

Handbook of Practical Immunohistochemistry

Frequently Asked Questions
Author: Fan Lin,Jeffrey Prichard
Publisher: Springer
ISBN: 1493915789
Category: Medical
Page: 764
View: 7723

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In a conceptually current, quick-reference, Question & Answer format, the second edition of Handbook of Practical Immunohistochemistry: Frequently Asked Questions continues to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue microarrays (TMA) of over 10,000 tumors and normal tissue to validate common diagnostic panels and provide the best reproducible data for diagnostic purposes. Fully revised and updated from the first edition, the new features of the second edition include over 200 additional questions or revised questions with an IHC panel to answer each question; over 250 new color photos and illustrations; over 20 new useful biomarkers; hundreds of new references; several new chapters to cover phosphoproteins, rabbit monoclonal antibodies, multiplex IHC stains, overview of predictive biomarkers, and integration of IHC into molecular pathology; many new coauthors who are international experts in a related field; many updated IHC panels using Geisinger IHC data collected from over 10,000 tumors and normal tissues; and updated appendices containing detailed antibody information for both manual and automated staining procedures. Comprehensive yet practical and concise, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions, Second Edition will be of great value for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.

Dictionary of Pharmaceutical Medicine


Author: Gerhard Nahler
Publisher: Springer
ISBN: 3319506692
Category: Medical
Page: 396
View: 1716

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This dictionary defines various terms typically used in pharmaceutical medicine. A new, 4th edition includes adaptations of the text to the steadily increasing regulatory requirements, particularly in the area of genetics/gene therapy, product quality (e.g., protection against falsified medicines) and of product safety (pharmacovigilance). Further evolving areas that are covered by the 4th edition are typical “grey zones” (health effects often borderline to medicinal products) such as cosmetics and dietary supplements where misleading information is prohibited on one hand but where any health claims need formal authorisation on the other. These but also other areas are reviewed and presented in an updated and – if justified – in an enlarged form.

Molecular Biomethods Handbook


Author: John M. Walker,Ralph Rapley
Publisher: Springer Science & Business Media
ISBN: 9781603273756
Category: Science
Page: 1124
View: 2303

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Recent advances in the biosciences have led to a range of powerful new technologies, particularly nucleic acid, protein and cell-based methodologies. The most recent insights have come to affect how scientists investigate and define cellular processes at the molecular level. This book expands upon the techniques included in the first edition, providing theory, outlines of practical procedures, and applications for a range of techniques. Written by a well-established panel of research scientists, the book provides an up-to-date collection of methods used regularly in the authors’ own research programs.

Handbook of Genomics and the Family

Psychosocial Context for Children and Adolescents
Author: Kenneth P. Tercyak
Publisher: Springer Science & Business Media
ISBN: 9781441958006
Category: Medical
Page: 615
View: 6644

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This book introduces readers to the study of how genes, singly and in combination with each other and the environment, affect health and behavior. It provides family-focused perspectives relating to genetic counseling and education.

Handbook of Pharmaceutical Biotechnology


Author: Shayne C. Gad
Publisher: Wiley-Interscience
ISBN: N.A
Category: Medical
Page: 1659
View: 3181

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Describes the use of biotechnology to develop pharmaceuticals. This book gives the professional a basic tool to facilitate the development of biotech medicines by bringing together a general overview of biotechnology used in the drug development process, along with a compendium of regulations and validation methods.

Preventive and Predictive Genetics: Towards Personalised Medicine


Author: Godfrey Grech,Iris Grossman
Publisher: Springer
ISBN: 3319153447
Category: Science
Page: 378
View: 1701

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Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.

Biomedicalization

Technoscience, Health, and Illness in the U.S.
Author: Adele E. Clarke,Laura Mamo,Jennifer Ruth Fosket,Jennifer R. Fishman,Janet K. Shim
Publisher: Duke University Press
ISBN: 0822391252
Category: Social Science
Page: 512
View: 6388

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The rise of Western scientific medicine fully established the medical sector of the U.S. political economy by the end of the Second World War, the first “social transformation of American medicine.” Then, in an ongoing process called medicalization, the jurisdiction of medicine began expanding, redefining certain areas once deemed moral, social, or legal problems (such as alcoholism, drug addiction, and obesity) as medical problems. The editors of this important collection argue that since the mid-1980s, dramatic, and especially technoscientific, changes in the constitution, organization, and practices of contemporary biomedicine have coalesced into biomedicalization, the second major transformation of American medicine. This volume offers in-depth analyses and case studies along with the groundbreaking essay in which the editors first elaborated their theory of biomedicalization. Contributors. Natalie Boero, Adele E. Clarke, Jennifer R. Fishman, Jennifer Ruth Fosket, Kelly Joyce, Jonathan Kahn, Laura Mamo, Jackie Orr, Elianne Riska, Janet K. Shim, Sara Shostak