Genetics and Genomics in Medicine


Author: Tom Strachan
Publisher: Taylor & Francis
ISBN: 1317594304
Category: Science
Page: 544
View: 5285

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Genetics and Genomics in Medicine is a new textbook written for undergraduate students, graduate students, and medical researchers that explains the science behind the uses of genetics and genomics in medicine today. Rather than focusing narrowly on rare inherited and chromosomal disorders, it is a comprehensive and integrated account of how geneti

Gentechnologie für Einsteiger


Author: Terence A. Brown
Publisher: Springer
ISBN: 9783827413024
Category:
Page: 409
View: 2783

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T. A. Browns "Gentechnologie fA1/4r Einsteiger" hat sich in mehreren Auflagen international als StandardeinfA1/4hrung in die Genklonierung und DNA-Analyse etabliert. Das Grundlagenlehrbuch setzt nur wenig Kenntnisse in Molekularbiologie und Genetik voraus und erlAutert in klarer Sprache sowohl die fundamentalen Prinzipien der wichtigsten gentechnologischen Methoden als auch die immer breiter werdende Palette ihrer Anwendungen. Die groAe Bedeutung der Gentechnologie fA1/4r die Grundlagenforschung und fA1/4r neue Entwicklungen in Biotechnologie und Medizin wird klar herausgearbeitet. Aoeber 250 zweifarbige Illustrationen erleichtern das VerstAndnis des Stoffes und machen die Konzepte und Arbeitstechniken der Gentechnologen anschaulich. Die neue Auflage ist vollstAndig A1/4berarbeitet und enthAlt zwei neue Kapitel. Eines prAsentiert die Methoden, mit denen man ganze Genome sequenziert, und beschreibt, was man aus den gewonnenen Sequenzinformationen ablesen kann. Das zweite widmet sich den Anwendungen der Gentechnologie in der Gerichtsmedizin - ein spannendes und aufschlussreiches Beispiel des Einsatzpotenzials der DNA-Analyse. Der groAen Bedeutung der Polymerasekettenreaktion (PCR) entsprechend wird diese Technik jetzt in einem frA1/4hen Abschnitt des Buches behandelt und durchgehend stArker berA1/4cksichtigt.

Genomics and Health in the Developing World


Author: Dhavendra Kumar
Publisher: Oxford University Press
ISBN: 0195374754
Category: Medical
Page: 1501
View: 5107

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This book is designed to be the first major text to discuss advances in medical genetics in the developing world.

Genomic Medicine

Principles and Practice
Author: Dhavendra Kumar,Charis Eng
Publisher: Oxford University Press (UK)
ISBN: 019989602X
Category: Medical
Page: 814
View: 2314

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Preceded by Genomics and clinical medicine / edited by Dhavendra Kumar. [First edition]. 2008.

Molekulare Humangenetik


Author: Tom Strachan,Andrew P. Read
Publisher: Spektrum Akademischer Verlag
ISBN: 9783827414939
Category: Science
Page: 802
View: 4393

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Die vorliegende 3. Auflage der Molekularen Humangenetik ist völlig neu überarbeitet - unter Berücksichtigung der Entdeckungen, die im Zuge und in der Folge des Human Genome Project gemacht wurden. Die einführenden Kapitel (Teil I) beschreiben die Grundlagen wie DNA-Struktur und -Funktion, Chromosomen, Zellen und Entwicklung, Stammbaumanalysen und grundlegende Techniken im Labor. In Teil II werden die verschiedenen Genomsequenzierungsprojekte und die dadurch ermöglichten Einblicke in Organisation, Expression, Variabilität und Evolution des menschlichen Genoms gezeigt. Die Kartierung, Identifizierung und Diagnose der Ursachen von mendelnden und komplexen Krankheiten sowie Krebs ist Schwerpunkt von Teil III. Der letzte Teil gibt Ausblicke auf die funktionelle Genomik und Bioinformatik, auf Tiermodelle und Therapien. Das Buch soll eine Brücke bilden zwischen den grundlegenden Lehrbüchern und der Forschungsliteratur, sodass auch Interessierte mit relativ wenig Hintergrundwissen zum Thema die neuesten Forschungsergebnisse lesen und beurteilen können.

Cardiovascular Genetics and Genomics in Clinical Practice


Author: Donna K. Arnett, PhD,Sanjiv J. Shah, MD
Publisher: Demos Medical Publishing
ISBN: 1617051780
Category: Medical
Page: 246
View: 5144

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Weighted Numerical Score: 100 - 5 Stars! This is a systematic guide to cardiovascular genetics and genomics from basic concepts to clinical application. It organizes a large volume of information from an active area of research, which holds promise for future discovery. --Doody's Reviews Cardiovascular Genetics and Genomics in Clinical Practice presents clinical cases to illuminate basic concepts of cardiovascular genetics and genomics as practitioners encounter them in day-to-day practice. The unique use of real-world case discussions facilitates the memorization and understanding of basic principles, which can be more readily applied to actual cases. Cardiovascular Genetics and Genomics in Clinical Practice features a step-by-step learning process that begins with an easy-to-understand "primer" of basic scientific concepts regarding cardiovascular genetics and genomics followed by state-of-the-art research and applications for treatment of cardiovascular disorders. Expert clinicians and researchers describe illustrative cases for each topic along with detailed discussions of current scientific understanding and its application in current disease management and treatment. Summaries, key teaching points, and illustrations are highlighted to facilitate quick recall and review. The book will be useful for cardiovascular clinicians in training, board preparation, or as a review for those already in clinical practice. Cardiovascular Genetics and Genomics in Clinical Practice features: Clinical case scenarios to illuminate the basic concepts of cardiovascular genetics and genomics as they are used in daily practice Explanation of fundamental concepts as a foundation for more in-depth understanding Detailed discussions of current scientific knowledge and clinical management The expertise of renowned clinician-scientists in the field Real practical insight for practice

Genomic and Personalized Medicine


Author: N.A
Publisher: Academic Press
ISBN: 0123822289
Category: Science
Page: 1350
View: 2443

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Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Thompson & Thompson Genetics in Medicine E-Book


Author: Robert L. Nussbaum,Roderick R. McInnes,Huntington F Willard
Publisher: Elsevier Health Sciences
ISBN: 1437700934
Category: Medical
Page: 600
View: 7623

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Through six editions, Thompson & Thompson's Genetics in Medicine has been a well-established favorite textbook on this fascinating and rapidly evolving field, integrating the classic principles of human genetics with modern molecular genetics to help you understand a wide range of genetic disorders. The 7th edition incorporates the latest advances in molecular diagnostics, the Human Genome Project, and much more. More than 240 dynamic illustrations and high-quality photos help you grasp complex concepts more easily. This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included. Acquire the state-of-the-art knowledge you need on the latest advances in molecular diagnostics, the Human Genome Project, pharmacogenetics, and bio-informatics. Better understand the relationship between basic genetics and clinical medicine with a variety of clinical case studies. Recognize a wide range of genetic disorders with visual guidance from more than 240 dynamic illustrations and high-quality photos. This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included.

Oxford Desk Reference: Clinical Genetics and Genomics


Author: Helen V. Firth,Jane A. Hurst
Publisher: Oxford University Press
ISBN: 0192519832
Category: Medical
Page: 824
View: 6018

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A popular and easy-to-use guide, this book is a must-have tool for clinical consultations in genetics and genomic medicine. Ideal for quick reference during practice, it covers the process of diagnosis, investigation, management, and counselling for patients. With a strong evidence base and international guidelines, it puts reliable and trustworthy guidance at your fingertips. Designed for use as a first-line guide, the A to Z format ensures it's accessible, and the simple layout makes it easy to assimilate information. Highly illustrated, the book also contains up-to-date glossaries of terms used in genetics and dysmorphology providing quick reference for key concepts. The second edition is an eagerly anticipated update of the gold standard in the specialty. It covers new developments in the field, particularly the advent of genome-wide sequencing and major updates in cancer. Fifteen new topics have been added, including Sudden cardiac death, Neonatal screening, and Ciliopathies. The authors have used their experience to devise a practical clinical approach to many common genetic referrals, both outpatient and ward based. The most common Mendelian disorders, chromosomal disorders, congenital anomalies and syndromes are all covered, and where available diagnostic criteria are included. In addition there are chapters on familial cancer and pregnancy-related topics such as fetal anomalies, teratogens, prenatal and pre-implantation diagnosis and non-invasive prenatal testing. The book also provides information on the less common situations where management is particularly complex. Both practical and pertinent, Oxford Desk Reference: Clinical Genetics and Genomics is the companion you need by your side during clinical consultations.

The Busy Physician’s Guide To Genetics, Genomics and Personalized Medicine


Author: Kevin M. Sweet,Ron C. Michaelis
Publisher: Springer Science & Business Media
ISBN: 9789400711471
Category: Medical
Page: 211
View: 2735

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In the coming decade, the focus of medicine will shift from a disease-oriented approach, where the physician prescribes according to the disease the patient has, to a personalized approach, in which the physician first considers the patient’s individual biochemistry before prescribing a treatment. Personalized medicine has the potential to improve efficacy and safety in virtually all fields of medicine. Unfortunately, few physicians feel confident in their ability to apply the principles of genetics and genomics upon which personalized medicine is based to their practice. This book is intended to help the practicing physician understand and apply the principles of genetic and genomic medicine, regardless of his/her level of background in the field. It provides a thorough foundation/review of classical genetic principles, with an emphasis on how these principles apply to personalized medicine and common complex diseases. In addition, it provides a wide-ranging review of the inroads that personalized medicine has made into several fields, including cancer, psychiatric disorders, cardiovascular disease, substance abuse, Alzheimer disease, respiratory diseases, type 2 diabetes and macular degeneration. Most importantly, this book is intended to enable the practicing physician, physician assistants and their entire healthcare team to anticipate the developments that will emerge in the near future, and stay current with the field as it expands.

A Short History of Medical Genetics


Author: Peter S. Harper
Publisher: Oxford University Press
ISBN: 0195187504
Category: Medical
Page: 557
View: 2072

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Historians and social scientists will likewise find this book an important foundation for future detailed studies, which are urgently needed."--BOOK JACKET.

Genetik für Dummies


Author: Tara Rodden Robinson
Publisher: John Wiley & Sons
ISBN: 3527811478
Category: Science
Page: 400
View: 2272

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Die Genetik ist eine der Naturwissenschaften, deren Wissen am schnellsten wächst und deren Erkenntnisse ständig in Bewegung und in der Diskussion sind. "Genetik für Dummies" erklärt, was überhaupt hinter diesem spannenden Thema steckt. Die Autorin Tara Rodden Robinson erklärt die Grundlagen der Vererbungslehre wie die Mendelschen Regeln, wie Zellen aufgebaut sind und sie sich teilen. Sie zeigt, wie die DNA aufgebaut ist, wie sie kopiert und richtig in Proteine übersetzt wird. Außerdem geht sie auf die Bedeutung der Genetik in der Humanmedizin ein, wie Genmutationen und Erbkrankheiten entstehen. Sie erläutert, was beim Klonen passiert und was sich überhaupt hinter dem Begriff Gentechnik verbirgt. Auch die heißen Themen wie Stammzellentherapie und der Einsatz der Genetik in der Rechtsmedizin werden behandelt.

Embryologie

Entwicklungsstadien, Frühentwicklung, Organogenese, Klinik
Author: Keith L. Moore,Trivedi V. N. Persaud
Publisher: Elsevier,Urban&FischerVerlag
ISBN: 9783437411120
Category: Embryology
Page: 595
View: 9942

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Issues in Genetic Medicine: 2012 Edition


Author: N.A
Publisher: ScholarlyEditions
ISBN: 1481645552
Category: Medical
Page: 678
View: 6658

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Issues in Genetic Medicine / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Genetic Research. The editors have built Issues in Genetic Medicine: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genetic Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Genetic Medicine: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Human Molecular Genetics 3


Author: T. Strachan,Andrew P. Read
Publisher: Garland Science
ISBN: 9780815341840
Category: Science
Page: 674
View: 4757

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Professors Tom Strachan & Andrew Read awarded the Education Award 2007 of the ESHG for their outstanding contribution to the dispersal of knowledge of modern human molecular genetics among students and professionals. Following the completion of the Human Genome Project the content and organization of the third edition of Human Molecular Genetics has been thoroughly revised. * Part One (Chapters 1-7) covers basic material on DNA structure and function, chromosomes, cells and development, pedigree analysis and the basic techniques used in the laboratory. * Part Two (Chapters 8-12) discusses the various genome sequencing projects and the insights they provide into the organisation, expression, variation and evolution of our genome. * Part Three (Chapters 13-18) focuses on mapping, identifying and diagnosing the genetic causes of mendelian and complex diseases and cancer. * Part Four (Chapters 19-21) looks at the wider horizons of functional genomics, proteomics, bioinformatics, animal models and therapy. There are new chapters on cells and development and on functional genomics. The sections on complex diseases have been completely rewritten and reorganized, as has the chapter on Genome Projects. Other changes include a new section on molecular phylogenetics (Chapter 12) and the introduction of 'Ethics Boxes' to discuss some of the implications of the new knowledge. Virtually every page has been revised and updated to take account of the stunning developments of the past four years since the publication of the last edition of Human Molecular Genetics. Features: * Integration of Human Genome Project data throughout the book * Two new chapters 'Cells and Development' (Chapter 3) and 'Beyond the Genome Project: Functional Genomics, Proteomics and Bioinformatics' (Chapter 19) * Completely rewritten and reorganised coverage of complex disease genetics * Increased emphasis on gene function and on applications of genetic knowledge, including ethical issues * More prominence given to novel approaches to treating disease, such as cell-based therapies, pharmacogenomics, and personalised medicine * Special topic boxes that include detailed coverage of ethical, legal and social issues, including eugenics, genetic testing and discrimination, germ-line gene therapy and genetic enhancement, and human cloning * Contains two indices: a general index and one that contains names of diseases and disorders Supplements: Art of HMG3 (CD-ROM) 0-8153-4183-0: £34.00

Ethical Dilemmas in Genetics and Genetic Counseling

Principles through Case Scenarios
Author: Janice Berliner MS, CGC
Publisher: Oxford University Press
ISBN: 0190206640
Category: Medical
Page: 224
View: 6750

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Knowledge of the genetic basis of human diseases is growing rapidly, with important implications for pre-conceptional, prenatal, and predictive testing. While new genetic testing offers better insight into the causes of and susceptibility for heritable diseases, not all inherited diseases that can be predicted on the basis of genetic information can be treated or cured. Should we test everyone who wants to know his or her genetic status, even when there are no possibilities for treatment? What is the role of the "right-not-to-know?" Do we test children for adult onset disorders because the parents just "have to know" or do we respect the children's right to choose when they are older? Do we allow commercial companies to offer genetic tests directly to consumers without the proper oversight regarding what the test results will mean? By using a creative approach that focuses on a single extended family as a case example to illustrate each chapter's key point, the authors elucidate ethical issues arising in the genetics clinic and laboratory surrounding many timely issues, including: · prenatal and pre-implantation genetic diagnosis · assisted reproductive technologies · incidental findings in genetic testing · gene patenting · testing children for adult onset disorders · direct to consumer testing Ethical Dilemmas in Genetic Counseling: Principles through Case Scenarios is essential reading for anyone interested in the ethical issues surfacing in common genetics practice. Written exclusively by genetic counselors, it makes a significant contribution to the field of ethics in genetics and thus will appeal not only to genetic counselors but to physicians, nurses, and all those concerned with bioethics and social science.

Genomics and Personalized Medicine

What Everyone Needs to Know
Author: Michael Snyder
Publisher: Oxford University Press
ISBN: 0190234768
Category: Genomics
Page: 184
View: 8301

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In 2001 the Human Genome Project succeeded in mapping the DNA of humans. This landmark accomplishment launched the field of genomics, the integrated study of all the genes in the human body and the related biomedical interventions that can be tailored to benefit a person's health. Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual's genetic sequence -- their genome -- against known elements of "Big Data," elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is limitless. This entry in the What Everyone Needs to Know series offers an authoritative resource on the prospects and realities of genomics and personalized medicine. As this science continues to alter traditional medical paradigms, consumers are faced with additional options and more complicated decisions regarding their health care. This book provides the essential information everyone needs.

Vogel and Motulsky's Human Genetics

Problems and Approaches
Author: Michael Speicher,Stylianos E. Antonarakis,Arno G. Motulsky
Publisher: Springer Science & Business Media
ISBN: 3540376542
Category: Medical
Page: 981
View: 2841

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The fourth edition of this classical reference book can once again be relied upon to present a cohesive and up-to-date exposition of all aspects of human and medical genetics. Human genetics has become one of the main basic sciences in medicine, and molecular genetics is increasingly becoming a major part of this field. This new edition integrates a wealth of new information - mainly describing the influence of the "molecular revolution" - including the principles of epigenetic processes which together create the phenotype of a human being. Other revisions are an improved layout, sub-division into a larger number of chapters, as well as two-colour print throughout for ease of reference, and many of the figures are now in full colour. For graduates and those already working in medical genetics.

Epigenetik

Ethische, rechtliche und soziale Aspekte
Author: Reinhard Heil,Stefanie B. Seitz,Harald König,Jürgen Robienski
Publisher: Springer-Verlag
ISBN: 3658100370
Category: Philosophy
Page: 211
View: 3405

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Innerhalb der letzten zehn Jahre hat sich die Epigenetik als ein Zweig der Molekulargenetik herausgebildet und erlebt einen regelrechten Hype. Die moderne Epigenetik vereint Wissenschaftlerinnen und Wissenschaftler aus den Lebenswissenschaften, der organischen Chemie, der Informatik und den Ingenieurwissenschaften bei der Beantwortung der Frage, wie Umwelteinflüsse die Genexpression langfristig und bis in die folgenden Generationen beeinflussen können. Der Band untersucht die wenig beachteten ethischen, rechtlichen und sozialen Aspekte der Epigenetik aus interdisziplinärer Perspektive.

Das Zentralnervensystem des Menschen

ein Atlas mit Begleittext
Author: Rudolf Nieuwenhuys,Johan Voogd,Christiaan van Huijzen
Publisher: N.A
ISBN: 9780387505237
Category:
Page: 461
View: 1170

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