Essentials of Clinical Research


Author: Stephen P. Glasser
Publisher: Springer
ISBN: 3319054708
Category: Medical
Page: 461
View: 7437

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In its extensively revised and updated Second Edition, this book provides a solid foundation for readers interested in clinical research. Discussion encompasses genetic, pharmacoepidemiologic and implementation research. All chapters have been updated with new information and many new tables have been added to elucidate key points. The book now offers discussion on how to handle missing data when analyzing results, and coverage of Adaptive Designs and Effectiveness Designs and new sections on Comparative Effectiveness Research and Pragmatic Trials. Chapter 6 includes new material on Phase 0 Trials, expanded coverage of Futility Trials, a discussion of Medical Device approval, Off Label Drug use and the role of the FDA in regulating advertising. Additional new information includes the role of pill color and shape in association with the placebo effect and an examination of issues surrounding minority recruitment. The final chapter offers a new section on manuscript preparation along with a discussion of various guidelines being adopted by journals: CONSORT, STROBE, PRISMA, MOOSE and others; and coverage of Conflicts of Interest, Authorship, Coercive Citation, and Disclosures in Industry-Related Associations. Building on the strengths of its predecessor in its comprehensive approach and authoritative advice, the new edition offers more of what has made this book a popular, trusted resource for students and working researchers alike.

Essentials of Apoptosis

A Guide for Basic and Clinical Research
Author: Xiao-Ming Yin,Zheng Dong
Publisher: Springer Science & Business Media
ISBN: 9781603273817
Category: Science
Page: 742
View: 671

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This is the second edition of the comprehensive, concise summary of apoptosis research. It covers the major concepts, molecular architecture, the biochemical pathways, and pathophysiological significance of apoptosis. This book provides a guideline of standard biochemical and cell biologic approaches to apoptosis bench work with an emphasis on translational clinical applications for immune disorders, cancer research, ischemia, and neuronal degeneration. Since the original publication in 2003, the apoptosis field has expanded rapidly – chapters not only need to be revised and expanded, but there is a need for all new chapters covering exciting advances in bioinformatics, systems biology, oxidative stress, etc.

Principles and Practice of Clinical Research


Author: John I. Gallin,Frederick P Ognibene,Laura Lee Johnson
Publisher: Academic Press
ISBN: 0128499044
Category: Science
Page: 824
View: 3432

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Principles and Practice of Clinical Research, Fourth Edition has been thoroughly revised to provide a comprehensive look at both the fundamental principles and expanding practice of clinical research. New to this edition of this highly regarded reference, authors have focused on examples that broadly reflect clinical research on a global scale while including a discussion of international regulations, studies, and implications. In addition to key topics such as bioethics, clinical outcome data, cultural diversity, protocol guidelines, and “omic platforms, this edition contains new chapters devoted to electronic health records and information resources for clinical researchers, as well as the many opportunities associated with big data. Covering a vast number of topics and practical advice for both novice and advanced clinical investigators, this book is a highly relevant and essential resource for all those involved in conducting research. Features input from experts in the field dedicated to translating scientific research from bench to bedside and back Provides expanded coverage of global clinical research Contains hands-on, practical suggestions, illustrations, and examples throughout Includes new chapters on the international regulation of drugs and biologics, the emergence of the important role of comparative effectiveness research and how to identify clinical risks and manage patient safety in a clinical research setting

Essentials of Spinal Cord Injury

Basic Research to Clinical Practice
Author: Michael G. Fehlings,Alexander R. Vaccaro,Maxwell Boakye
Publisher: Thieme
ISBN: 1604067276
Category: Medical
Page: 682
View: 9582

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Essentials of Spinal Cord Injury is written for the spinal cord injury (SCI) team and reflects the multidisciplinary nature of treating patients with SCI. It integrates emerging medical and surgical approaches to SCI with neuroanatomy, neurophysiology, neuroimaging, neuroplasticity, and cellular transplantation. This comprehensive yet concise reference will enable neurosurgeons, orthopedic surgeons, neurologists, and allied health professionals caring for SCI patients to translate research results into patient care. It is also an excellent resource for those preparing for the board exam in SCI medicine. Key Features: Material is cross-referenced to highlight relationships between the different areas of SCI Chapters are concise, focused, and include key points, pearls, and pitfalls An Overview of the Literature table is provided in most chapters, giving readers a meaningful distillation of each publication referenced Each editor is a world-renowned expert in one of these core disciplines involved in the management of SCI patients: neurosurgery, orthopedic surgery, spinal cord science, and rehabilitative medicine This is a must-have guide that all neurosurgeons, orthopedic surgeons, neurologists, and allied health professionals involved in the care of spinal cord injury patients should have on their bookshelf.

The Lancet Handbook of Essential Concepts in Clinical Research


Author: Kenneth F. Schulz,David A. Grimes
Publisher: The Lancet
ISBN: N.A
Category: Medical
Page: 223
View: 6432

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The needs of clinicians predominate throughout the text, but these needs overlap with those of researchers especially in chapters covering randomized controlled trials. For readers to assess trials accurately they need to understand relevant guidelines on the conduct of trials that are emerging from methodological research. In presenting these discussions to clinicians these chapters will help researchers who also do randomized trials and provide a methodological background that enhances the quality and quantity of their research productivity. Enables clinicians to read the medical literature more critically Chapters cover: descriptive studies, cohort studies, case control studies, bias, and screening tests Five chapters dedicated to randomized controlled trials

Fundamentals of Clinical Trials


Author: Lawrence M. Friedman,Curt D. Furberg,David L. DeMets,David M. Reboussin,Christopher B. Granger
Publisher: Springer
ISBN: 331918539X
Category: Medical
Page: 550
View: 3432

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This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing and international trials. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful.

Medical Research Essentials


Author: Rania Esteitie
Publisher: McGraw Hill Professional
ISBN: 007178165X
Category: Medical
Page: 104
View: 2672

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LEARN THE EFFICIENT, EASY WAY TO CONDUCT MEDICAL RESEARCH PERFECT FOR ANYONE CONSIDERING A MEDICAL RESEARCH PROJECT! This concise handbook tells you everything you need to know about medical research. You will learn how to read, understand, and ultimately perform it. Medical Research Essentials walks you step by step through the entire research process, from how to read and critique an article, to presenting your own data. Filled with flowcharts, algorithms, diagrams, and tables, Medical Research Essentials is like having an experienced mentor at your side! THIS ULTIMATE HANDBOOK FOR INTERPRETING AND CONDUCTING MEDICAL RESEARCH OFFERS CONCISE COVERAGE OF: How to critically read and interpret medical literature The best methods of organizing and analyzing data Potential research projects that can be performed in a limited time frame How to design your own study and acquire funding Understanding and using medical statistics

Essentials of Clinical Pulmonology


Author: Pallav Shah,Felix JF Herth,YC Gary YC Lee,Gerard J. Criner
Publisher: CRC Press
ISBN: 1498715796
Category: Medical
Page: 786
View: 6564

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Concise yet comprehensive, this textbook of clinical pulmonology provides pulmonologists and respiratory disease physicians with all the key information that they need to know to manage the patient through the diagnosis and treatment journeys. From the most common condition to the rarest, each disease is consistently presented and comprehensively covered giving the reader just the key facts. Building upon the basic sciences and integrating these with clinical practice, each chapter has a consistent approach, is highly designed and visually appealing. Numerous illustrations, colour photographs, scans, bullet points, tables and algorithms ensure that the key information is available at a glance. The keynote sections serve as a useful revision aid as do the multiple choice questions. A truly international and highly experienced editorship with expert contributors from around the world ensure that the book remains a trusted source of information. * Concise yet thorough coverage ensures that the book is comprehensive in its approach * Each chapter is very consistent, synoptic and gives the key facts at a glance * Highly illustrated and visually appealing with numerous figures, photographs, boxes, red flags and clinical pearls * Truly international expert editors and contributors ensure that the book is a trusted source of information written by highly experienced teachers and clinicians. Set at the level between the definitive reference work and the clinical manual, Essentials of Clinical Pulmonology is an invaluable cornerstone for all pulmonologists whether trainees or experienced clinicians.

The Essentials of Biostatistics for Physicians, Nurses, and Clinicians


Author: Michael R. Chernick
Publisher: John Wiley & Sons
ISBN: 1118071948
Category: Medical
Page: 228
View: 7787

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A fundamental and straightforward guide to using and understanding statistical concepts in medical research Designed specifically for healthcare practitioners who need to understand basic biostatistics but do not have much time to spare, The Essentials of Biostatistics for Physicians, Nurses and Clinicians presents important statistical methods used in today's biomedical research and provides insight on their appropriate application. Rather than provide detailed mathematics for each of these methods, the book emphasizes what healthcare practitioners need to know to interpret and incorporate the latest biomedical research into their practices. The author draws from his own experience developing and teaching biostatistics courses for physicians and nurses, offering a presentation that is non-technical and accessible. The book begins with a basic introduction to the relationship between biostatistics and medical research, asking the question "why study statistics?," while also exploring the significance of statisitcal methods in medical literature and clinical trials research. Subsequent chapters explore key topics, including: Correlation, regression, and logistic regression Diagnostics Estimating means and proportions Normal distribution and the central limit theorem Sampling from populations Contingency tables Meta-analysis Nonparametric methods Survival analysis Throughout the book, statistical methods that are often utilized in biomedical research are outlined, including repeated measures analysis of variance, hazard ratios, contingency tables, log rank tests, bioequivalence, cross-over designs, selection bias, and group sequential methods. Exercise sets at the end of each chapter allow readers to test their comprehension of the presented concepts and techniques. The Essentials of Biostatistics for Physicians, Nurses, and Clinicians is an excellent reference for doctors, nurses, and other practicing clinicians in the fields of medicine, public health, pharmacy, and the life sciences who need to understand and apply statistical methods in their everyday work. It also serves as a suitable supplement for courses on biostatistics at the upper-undergraduate and graduate levels.

Clinical Research Law and Compliance Handbook


Author: John E. Steiner
Publisher: Jones & Bartlett Learning
ISBN: 9780763747251
Category: Business & Economics
Page: 460
View: 8554

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Written in clear, practical language, this title will help you navigate the clinical research maze as it addresses critically important legal, operational, ethical and business issues associated with clinical research trials.

Essentials of Writing Biomedical Research Papers. Second Edition


Author: Mimi Zeiger
Publisher: McGraw Hill Professional
ISBN: 0071503854
Category: Science
Page: 440
View: 3443

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Provides immediate help for anyone preparing a biomedical paper by givin specific advice on organizing the components of the paper, effective writing techniques, writing an effective results sections, documentation issues, sentence structure and much more. The new edition includes new examples from the current literature including many involving molecular biology, expanded exercises at the end of the book, revised explanations on linking key terms, transition clauses, uses of subheads, and emphases. If you plan to do any medical writing, read this book first and get an immediate advantage.

Clinical Research Manual

Practical Tools and Templates for Managing Clinical Research
Author: Ruth Jennifer Cavalieri,Mark E. Rupp
Publisher: Sigma Theta Tau
ISBN: 1937554635
Category: Medical
Page: 262
View: 8614

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Clinical Research Manual: Practical Tools and Templates for Managing Clinical Research is the "must-have" book for anyone working in the day-to-day operations of a research study or clinical trial. Filled with tools, techniques, and templates, this manual offers clinical researchers, principal investigators, and research coordinators the foundation they need to successfully organize complex trials.

Essentials of Medical Biochemistry

With Clinical Cases
Author: N. V. Bhagavan,Chung-Eun Ha
Publisher: Academic Press
ISBN: 0124166970
Category: Science
Page: 752
View: 9481

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Essentials of Medical Biochemistry, Second Edition: With Clinical Cases is the most condensed, yet detailed biochemistry overview available on the topic. It presents contemporary coverage of the fundamentals of biochemistry, emphasizing relevant physiologic and pathophysiologic biochemical concepts. Pivotal clinical case studies aid in understanding basic science in the context of diagnosis and treatment of human diseases, and the text illuminates key topics in molecular immunology and hemostasis. Users will find basic and fundamental concepts that will aid students and professionals in biochemistry, medicine, and other healthcare disciplines. the text is a useful refresher that will help users meet USMLE and other professional licensing examination requirements, providing thorough introductions, key points, multicolored illustrations of chemical structures and figures, fact-filled tables, and recommended reading lists. Presents essential biochemical concepts within the context of their biological functions Contains key clinical case studies in each chapter to enhance understanding of basic science and aid in further comprehension Offers instructional overview figures, flowcharts, tables and multicolored illustrations Includes integrated, recommended reading reference lists within the text Provides an online ancillary package inclusive of PowerPoint images and more than 500 study questions to aid in comprehension and USMLE exam preparation

Clinical Research for the Doctor of Nursing Practice


Author: Terry
Publisher: Jones & Bartlett Learning
ISBN: 1284148602
Category: Medical
Page: 382
View: 8601

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Clinical Research for the Doctor of Nursing Practice, Third Edition is a must-have text focused on teaching students how to conduct research needed for their capstone project.

Essentials of Rehabilitation Research

A Statistical Guide to Clinical Practice
Author: Richard P Di Fabio
Publisher: F.A. Davis
ISBN: 080363790X
Category: Medical
Page: 384
View: 5052

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Enhance your clinical practice and your understanding of rehabilitation literature through applied statistics! Step-by-step, this interactive learning experience makes clinically relevant statistical procedures easier to understand, organize, interpret, and use when evaluating patients and the effectiveness of your practice. Only statistical procedures with direct clinical application have been selected to guide you through patient assessments, selecting the best tools for your practice, enhancing your understanding of predicting prognosis and responders to treatment, and outlining a method to critique clinical practice guidelines. With this reader-friendly, real-world approach you’ll be able to meet the need for evidence to support your practice, gain a deeper understanding of clinical research, and systematically evaluate patient outcomes.

Global Health 101


Author: Richard Skolnik
Publisher: Jones & Bartlett Publishers
ISBN: 0763797510
Category: Medical
Page: 434
View: 1809

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Rev. ed. of: Essentials of global health. c2008.

Essentials of Clinical Hypnosis

An Evidence-based Approach
Author: Steven J. Lynn,Irving Kirsch
Publisher: Amer Psychological Assn
ISBN: N.A
Category: Medical
Page: 271
View: 2745

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"This book is essentially clinical in nature. But it is a clinical book with a research base. The clinical strategies and techniques that are presented are ones that the authors have used in their practice and that they have taught their graduate students to use. They are procedures with an evidential base. Many of the specific techniques they describe have been validated in clinical trials and outcome studies, and their approach to most strategic issues has been shaped by their understanding of the research literature in hypnosis, psychotherapy, and psychopathology. If there is a fundamental difference between this book and the many other guides that have been published on clinical applications of hypnosis, it is the degree to which the principles and practices the authors describe are evidence-based. Hence, the subtitle of this book. The authors aim to bring their enthusiasm for integrating hypnosis with empirically supported methods to a wide readership and to move hypnosis more securely into the mainstream of established clinical practice." (PsycINFO Database Record (c) 2006 APA, all rights reserved).

Essentials of Stem Cell Biology


Author: Robert Lanza,Anthony Atala
Publisher: Academic Press
ISBN: 0124104274
Category: Science
Page: 712
View: 5271

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First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners, and students embracing the latest advances in stem cells. Representing the combined effort of 7 editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, and methods to the application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered. Contributions by Nobel Laureates and leading international investigators Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate Presented in full color with a glossary, highlighted terms, and bibliographic entries replacing references

Essentials of Medical Statistics


Author: Betty Kirkwood
Publisher: Wiley-Blackwell
ISBN: 9780632010523
Category: Medical
Page: 246
View: 8099

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A concise, straightforward introduction to medical statistics, this book covers all the topics which a medical student or research worker is likely to encounter in routine work. It can be used for self-teaching, as a reference text, and as a useful companion to basic courses in medical statistics. The book consists of twenty short chapters, each including worked examples, the chapter order reflecting a logical progression of practical concepts rather than a formal mathematical development.

Essentials of a Successful Biostatistical Collaboration


Author: Arul Earnest
Publisher: CRC Press
ISBN: 1482226995
Category: Mathematics
Page: 308
View: 986

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The aim of this book is to equip biostatisticians and other quantitative scientists with the necessary skills, knowledge, and habits to collaborate effectively with clinicians in the healthcare field. The book provides valuable insight on where to look for information and material on sample size and statistical techniques commonly used in clinical research, and on how best to communicate with clinicians. It also covers the best practices to adopt in terms of project, time, and data management; relationship with collaborators; etc.