Classics in Total Synthesis

Targets, Strategies, Methods
Author: K. C. Nicolaou,E. J. Sorensen
Publisher: Wiley-VCH
ISBN: 9783527292318
Category: Science
Page: 821
View: 7979

Continue Reading →

K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.

Classics in Total Synthesis II

More Targets, Strategies, Methods
Author: K. C. Nicolaou,S. A. Snyder
Publisher: Wiley-VCH
ISBN: 9783527306848
Category: Science
Page: 658
View: 4249

Continue Reading →

Classics in Total Synthesis II is the long awaited sequel to Classics in Total Synthesis, a book that has made its mark as a superb tool for educating students and practitioners alike in the art of organic synthesis since its introduction in 1996. In this highly welcomed new volume, K. C. Nicolaou and Scott A. Snyder discuss in detail the most impressive accomplishments in natural product total synthesis during the 1990s and the first years of the 21st century. While all of the features that made the first volume of Classics so popular and unique as a teaching tool have been maintained, in this new treatise the authors seek to present the latest techniques and advances in organic synthesis as they beautifully describe the works of some of the most renowned synthetic organic chemists of our time. ? domino reactions, cascade sequences, biomimetic strategies, and asymmetric catalysis are systematically developed through the chosen synthesis ? cutting edge synthetic technologies are discussed in terms of mechanism and scope ? new reactions, such as olefin metathesis, are presented in mini-review style ? abundant references are given for further reading Graduate students, educators, and researchers in the fields of synthetic and medicinal chemistry will wish to have a copy of this book in their collection as an indispensable companion that both augments and supplements the original Classics in Total Synthesis. From reviews of "Classics in Total Synthesis": "... a volume, (..) which any chemist with an interest in synthetic organic chemistry will wish to acquire." JACS "...this superb book (..) will be an essential purchase for many organic chemists." Nature

Classics in Total Synthesis III

Further Targets, Strategies, Methods
Author: K. C. Nicolaou,Jason S. Chen
Publisher: John Wiley & Sons
ISBN: 3527329579
Category: Science
Page: 746
View: 3528

Continue Reading →

A wonderful tool for learning and teaching, and a must-have for all current and future organic, medicinal and biological chemists. --Book Jacket.

Biomimetic Organic Synthesis


Author: Erwan Poupon,Bastien Nay
Publisher: John Wiley & Sons
ISBN: 3527634762
Category: Science
Page: 1024
View: 2586

Continue Reading →

In this exciting 2 volume set, the approach and methodology of bio-inspired synthesis of complex natural products is laid out, backed by abundant practical examples from the authors' own work as well as from the published literature. Volume 1 describes the biomimetic synthesis of alkaloids. Volume 2 covers terpenes, polyketides, and polyphenols. A discussion of the current challenges and frontiers in biomimetic synthesis concludes this comprehensive handbook. Key features: Biomimetic Strategies have become an every-day tool not only for chemists but also for biologists. The synthetic applications are overwhelming, making this comprehensive 2 volume work a must-have for everyone working in the field. Unifying both synthetic and biosynthetic aspects, this book covers everything from organocatalysis and natural product synthesis to synthetic biology and even green chemistry.

Elemente der Syntheseplanung


Author: R.W. Hoffmann
Publisher: Spektrum Akademischer Verlag
ISBN: 9783827417251
Category: Science
Page: 206
View: 545

Continue Reading →

Bei der Syntheseplanung ist es wie beim Gebrauchtwagenkauf: Man kann folgenschwere Fehler machen, und jeder Fall ist anders! Und dennoch gibt es Tipps, woran man denken sollte und was man beachten muss! Dieses Buch führt in die elementaren Überlegungen ein, die man bei der Planung einer Synthese anstellen sollte. Diese Überlegungen illustriert R.W. Hoffmann mit zahlreichen Beispielen aus publizierten Synthesen. Bei jedem Beispiel gibt er die Originalliteraturstelle an, bei der Interessierte Details und weitere Erklärungen nachlesen können.

Efficiency in Natural Product Total Synthesis


Author: Pei-Qiang Huang,Zhu-Jun Yao,Richard P. Hsung
Publisher: John Wiley & Sons
ISBN: 1118940210
Category: Science
Page: 512
View: 4938

Continue Reading →

Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals

Molekülorbitale und Reaktionen organischer Verbindungen


Author: Ian Fleming
Publisher: John Wiley & Sons
ISBN: 3527330690
Category: Chemical bonds
Page: 399
View: 2007

Continue Reading →

Der lang erwartete Nachfolger des Klassikers "Grenzorbitale und Reaktionen organischer Verbindungen". Die Molekülorbitalheorie wird einfach, ohne komplizierte mathematische Formeln und mit vielen illustrativen Beispielen erklärt.

Natural Products in Medicinal Chemistry


Author: Stephen Hanessian
Publisher: John Wiley & Sons
ISBN: 3527676562
Category: Medical
Page: 652
View: 569

Continue Reading →

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer

Green Techniques for Organic Synthesis and Medicinal Chemistry


Author: Wei Zhang,Berkeley Cue
Publisher: John Wiley & Sons
ISBN: 0470711515
Category: Medical
Page: 742
View: 8897

Continue Reading →

Green chemistry is a new way of looking at organic synthesis and the design of drug molecules, offering important environmental and economic advantages over traditional synthetic processes. Pharmaceutical companies are increasingly turning to the principles of green chemistry in an effort to reduce waste, reduce costs and develop environmentally benign processes. Green Techniques for Organic Synthesis and Medicinal Chemistry presents an overview of the established and emerging techniques in green organic chemistry, highlighting their applications in medicinal chemistry. The book is divided into four parts: Introduction: Introduces the reader to the toxicology of organic chemicals,their environmental impact, and the concept of green chemistry. Green Catalysis: Covers a variety of green catalytic techniques including organocatalysis, supported catalysis, biocatalysis, fluorous catalysis, and catalytic direct C-H bond activation reactions. Green Synthetic Techniques: Presents a series of new techniques, assessing the green chemistry aspects and limitations (i.e. cost, equipment, expertise). Techniques include reactions in alternative solvents, atom economic multicomponent reactions, microwave and ultrasonic reactions, solid-supported synthesis, fluorous and ionic liquid-based recycling techniques, and flow reactors. Green Techniques in Pharmaceutical Industry: Covers applications of green chemistry concepts and special techniques for medicinal chemistry, including synthesis, analysis, separation, formulation, , and drug delivery. Process and business case studies are included to illustrate the applications in the pharmaceutical industry. Green Techniques for Organic Synthesis and Medicinal Chemistry is an essential resource on green chemistry technologies for academic researchers, R&D professionals and students working in organic chemistry and medicinal chemistry.

Asymmetric Organocatalysis in Natural Product Syntheses


Author: Mario Waser
Publisher: Springer Science & Business Media
ISBN: 3709111633
Category: Science
Page: 197
View: 3498

Continue Reading →

This book provides the reader with an illustrative overview concerning successful and widely used applications of organocatalysis in the field of natural product synthesis. The main focus will be on organocatalytic key-steps for each (multi-step) synthesis described, whereas other often particularly innovative transformations will be omitted, as this would be beyond the scope of this volume.

Der stumme Frühling


Author: Rachel Carson
Publisher: C.H.Beck
ISBN: 3406704220
Category: Nature
Page: 348
View: 3105

Continue Reading →

Der stumme Frühling erschien erstmals 1962. Der Titel bezieht sich auf das eingangs erzählte Märchen von der blühenden Stadt, in der sich eine seltsame, schleichende Seuche ausbreitet … Das spannend geschriebene Sachbuch wirkte bei seinem Erscheinen wie ein Alarmsignal und avancierte rasch zur Bibel der damals entstehendenÖkologie-Bewegung. ZumerstenMal wurde hier in eindringlichem Appell die Fragwürdigkeit des chemischen Pflanzenschutzes dargelegt. An einer Fülle von Tatsachen machte Rachel Carson seine schädlichen Auswirkungen auf die Natur und die Menschen deutlich. Ihre Warnungen haben seither nichts von ihrer Aktualität verloren.

Strategies and Tactics in Organic Synthesis


Author: Michael Harmata
Publisher: Academic Press
ISBN: 9780124502833
Category: Science
Page: 415
View: 4068

Continue Reading →

This title provides a forum for investigators to discuss their approach to the science and art of organic synthesis in a unique way. It provides a window into the world of design, function and synthesis that is at the leading edge of the molecular frontier.

Organische Chemie II für Dummies


Author: John T. Moore,Richard Langley
Publisher: John Wiley & Sons
ISBN: 3527707204
Category: Chemistry, Organic
Page: 360
View: 836

Continue Reading →

Die Organische Chemie, die Welt des Kohlenstoffs, ist spannend, vielschichtig und manchmal auch ein wenig schwer zu verstehen. Dieses Buch ist das richtige für Sie, wenn Sie etwas mehr als nur die Grundlagen der Organik verstehen müssen und etwas tiefer in die Materie eindringen wollen. Sie erfahren, was Sie über Alkohole, Ether und Spektroskopie wissen sollten, was aromatische Verbindungen ausmacht, was es mit Carbonylen auf sich hat und vieles mehr. Auch kniffelige Themen wie Organometalle, Amine und Biomoleküle kommen nicht zu kurz. So bietet John T. Moore in diesem Buch einen leicht verständlichen Überblick über die etwas fortgeschrittenere Organische Chemie.

The Way of Synthesis

Evolution of Design and Methods for Natural Products
Author: Tomas Hudlicky,Josephine W. Reed
Publisher: Wiley-VCH
ISBN: N.A
Category: Science
Page: 1032
View: 7083

Continue Reading →

This two-colored textbook presents not only synthetic ways to design organic compounds, it also contains a compilation of the most important total synthesis of the last 50 years with a comparative view of multiple designs for the same targets. It explains different tactics and strategies, making it easy to apply to many problems, regardless of the synthetic question in hand. Following a historical view of the evolution of synthesis, the book goes on to look at principles and issues impacting synthesis and design as well as principles and issues of methods. The sections on comparative design cover classics in terpenes and alkaloid synthesis, while a further section covers such miscellaneous syntheses as Maytansine, Palytoxin, Brevetoxin B and Indinavir. The whole is rounded off with a look at future perspectives and, what makes this textbook extraordinairy, with personal recollections of the chemists, who synthesized these fascinating compounds. With its attractive layout highlighting key parts and tactics using a second color, this is a useful tool for organic chemists, lecturers and students in chemistry, as well as those working in the chemical industry. "I think, as will many organic chemists, that the Hudlicky book will be the Bible of synthetic organic chemistry, the past, the present and the future. A hallmark publication." (Victor Snieckus)

Reactive Intermediates in Organic Chemistry

Structure, Mechanism, and Reactions
Author: Maya Shankar Singh
Publisher: John Wiley & Sons
ISBN: 3527678271
Category: Science
Page: 296
View: 4698

Continue Reading →

Most reactions in organic chemistry do not proceed in a single step but rather take several steps to yield the desired product. In the course of these multi-step reaction sequences, short-lived intermediates can be generated that quickly convert into other intermediates, reactants, products or side products. As these intermediates are highly reactive, they cannot usually be isolated, but their existence and structure can be proved by theoretical and experimental methods. Using the information obtained, researchers can better understand the underlying reaction mechanism of a certain organic transformation and thus develop novel strategies for efficient organic synthesis. The chapters are clearly structured and are arranged according to the type of intermediate, providing information on the formation, characterization, stereochemistry, stability, and reactivity of the intermediates. Additionally, representative examples and a problem section with different levels of difficulty are included for self-testing the newly acquired knowledge. By providing a deeper understanding of the underlying concepts, this is a musthave reference for PhD and Master Students in organic chemistry, as well as a valuable source of information for chemists in academia and industry working in the field. It is also ideal as primary or supplementary reading for courses on organic chemistry, physical organic chemistry or analytical chemistry.

Advanced organic chemistry


Author: Francis A. Carey,Richard J. Sundberg
Publisher: John Wiley & Sons
ISBN: 9783527292172
Category: Science
Page: 1635
View: 6856

Continue Reading →

Endlich gibt es ein weiterführendes Lehrbuch der Organischen Chemie in deutscher Sprache! Es wird die Studenten auf den Gebieten Reaktionsmechanismen, Stereochemie und insbesondere Organische Synthese bis zum Diplom begleiten, und darüber hinaus ist es ein äußerst nützliches Nachschlagewerk auch für Diplomanden und Doktoranden. Die deutsche Ausgabe wurde gegenüber dem Original nochmals erweitert und aktualisiert. Erste Dozentenstimmen: 'Die erste deutsche Ausgabe des Carey/Sundberg erfüllt alle Erwartungen an ein modernes Lehrbuch der Organischen Chemie.' - 'Es ist zur Zeit das beste Lehrbuch der Organischen Chemie und unentbehrlich für fortgeschrittene Studenten, Diplomanden und Doktoranden.' - 'Endlich! Ich empfehle dieses Buch bereits seit Jahren fortgeschrittenen Studenten.' - 'Es ist bezeichnend, daß es immer besonders motivierte und leistungsstarke Studenten waren, die mich fragten, ob ich ihnen den Carey/Sundberg empfehlen kann. Ich kann es.' - 'Endlich wird es ein ausgewogenes Lehrbuch zur Organischen Chemie für Fortgeschrittene in deutscher Sprache geben. Die Kompetenz der Herausgeber bürgt für hohen Standard.'

Pflanzenbiochemie


Author: Hans Walter Heldt,Birgit Piechulla
Publisher: Springer-Verlag
ISBN: 3662443988
Category: Science
Page: 597
View: 858

Continue Reading →

Die „Pflanzenbiochemie" hat sich im deutschsprachigen Raum, aber auch in zahlreichen Übersetzungen als Standardlehrbuch etabliert. Birgit Piechulla, Dozentin an der Universität Rostock, zeichnet als Co-Autorin bei dieser 5. Auflage verantwortlich und hat zusammen mit Hans-Walter Heldt das Buch gründlich überarbeitet und aktualisiert. Neueste wissenschaftliche Erkenntnisse fanden Eingang in dieses Buch, die sich auch in neuen Abbildungen sowie der stark überarbeiteten Literatur widerspiegeln. Besonderen Wert legen die Autoren darauf, die offenen, zukunftsweisenden Fragen, die den derzeitigen Stand unseres Wissens markieren, aufzuzeigen. Aktualität sowie die klare und verständliche Didaktik komplexer Sachverhalte darzustellen -- das sind die Kennzeichen dieses Lehrbuches. Mit sorgfältig erstellten zweifarbigen Abbildungen erfüllt es einen hohen didaktischen Anspruch und reiht sich unter die besten Biochemie-Lehrbücher.