Cancer Clinical Pharmacology


Author: Jan H. M. Schellens,Howard L. McLeod,David R. Newell
Publisher: Oxford University Press
ISBN: 9780192629661
Category: Medical
Page: 267
View: 2359

Continue Reading →

The book considers both the theory and practice of clinical pharmacology where it is relevant to cancer treatment. It covers the basics of clinical pharmacology in oncology and cancer therapeutics, discussing the specific classes of anti-cancer agents in detail. Edited and written by a mix of generalist cancer clinical pharmacologists and sub-specialists within this area, the book allows the reader to develop both general clinical pharmacology skills and specialist knowledge for particular cancer chemotherapy agents.

Clinical Pharmacology


Author: Morris J. Brown,Pankaj Sharma,Peter N. Bennett
Publisher: Elsevier Health Sciences
ISBN: 0702051136
Category: Medical
Page: 640
View: 8738

Continue Reading →

A thorough knowledge of pharmacological and therapeutic principles is vital if drugs are to be used safely and effectively for increasingly informed patients. Those who clearly understand how drugs get into the body, how they produce their effects, what happens to them in the body, and how evidence of their therapeutic effect is assessed, will choose drugs more skilfully, and use them more safely and successfully than those who do not. Now in a fully revised 11th edition, Clinical Pharmacology is essential reading for undergraduate medical students, junior doctors and anyone concerned with evidence-based drug therapy. Introductory first three sections cover general principle of clinical pharmacology; five subsequent sections cover drug treatment of disease organised by body system. Retains approachable style set by the original author, Professor Laurence. Emphasis throughout is on evidence-based and safe drug prescribing. Indian Advisory Board will ensure content reflects the needs of the devloping world.

Clinical Pharmacology, International Edition


Author: Morris J. Brown,Pankaj Sharma,Fraz A. Mir,Peter N. Bennett
Publisher: Elsevier Health Sciences
ISBN: 070207330X
Category: Medical
Page: 688
View: 8882

Continue Reading →

‘The very last thing a drug regulator wishes to be able to say is, like Lord Byron (1788-1824), on the publication of his poem Childe Harold’s Pilgrimage, ‘I awoke one morning and found myself famous.’ The twelfth edition of this long-established textbook of clinical pharmacology (first published in 1960) continues its fine tradition of balancing science and practice for improved evidence-based drug therapy and good prescribing in therapeutic settings increasingly complicated by intercurrent disease and polypharmacy. Coverage of all major therapeutic topics by body system. Introductory sections give brief chapter synopses. Case studies where relevant. Covers the needs of the developing world with a focus on practical prescribing and health technology assessment. Definition, tips, brief explanation boxes throughout. Interesting histories, etymologies and provenances of terms throughout. Entertaining footnotes throughout. ‘The very last thing a drug regulator wishes to be able to say is, like Lord Byron (1788-1824), on the publication of his poem Childe Harold’s Pilgrimage, ‘I awoke one morning and found myself famous.’ Fully updated throughout. New co-editor: Fraz Mir, Addenbrooke’s Hospital and Department of Medicine, University of Cambridge, Royal College of Physicians Associate International Director for South Asia. Now with free e-book on StudentConsult.

Symposium on Clinical Pharmacology

Biochemical Pharmacology
Author: William A. Creasey,Montague Lane,Alan C. Sartorelli
Publisher: Elsevier
ISBN: 1483139409
Category: Health & Fitness
Page: 242
View: 6664

Continue Reading →

Symposium on Clinical Pharmacology reviews advances in clinical pharmacology, with emphasis on how to materially improve the efficacy of cancer chemotherapy. Topics range from absorption, protein binding, distribution, and excretion of antineoplastic drugs to factors affecting the biotransformation and activity of antitumor drugs. The transport of tumor-inhibitory agents across cell membranes is also examined, together with factors influencing drug selectivity and the mechanisms of clinical drug resistance. This volume is comprised of 23 chapters and begins with a brief summary of the different kinds of pharmacokinetic models and how detailed kinetic investigations of a drug in animals may provide further insight into modes of its clinical use. The next chapter considers the chief factors in determining the effective concentration of a drug at a receptor site as well as the duration and intensity of drug effect, citing antineoplastic agents as examples. The role of enzymatic activation and inactivation in drug selectivity is also discussed, along with the general mechanisms of clinical resistance to cancer chemotherapy; biochemical and pharmacological principles of combination chemotherapy; and the reaction and effects of nitrosoureas. This book will be of interest to clinicians, pharmacologists, and biochemists.

Clinical Pharmacology

With STUDENTCONSULT Access
Author: Peter N. Bennett,Morris J. Brown
Publisher: Elsevier Health Sciences
ISBN: 0702039985
Category: Medical
Page: 704
View: 8362

Continue Reading →

This book is for students, doctors and indeed for all concerned with evidence-based drug therapy. A knowledge of pharmacological and therapeutic principles is essential if drugs/medicines are to be used safely and effectively for increasingly informed and critical patients. Doctors who understand how drugs get into the body, how they produce their effects, what happens to them in the body, and how evidence of their therapeutic effect is assessed, will choose drugs more skilfully, and use them more successfully than those who do not. The principles involved are neither so numerous nor so difficult to understand as to deter any prescriber, including those whose primary interests lie elsewhere than in pharmacology. All who use drugs cannot escape either the moral or the legal 'duty of care' to prescribe in an informed and responsible way. Introductory first three sections cover general principle of clinical pharmacology; five subsequent sections cover drug treatment of disease organised by body system. Retains approachable style set by the original author, Professor Laurence. Emphasis throughout is on evidence-based and safe drug prescribing. New colour design Increased use of graphics Slightly shorter by removal of out of date material

Roach's Introductory Clinical Pharmacology


Author: Susan M. Ford,Sally S. Roach
Publisher: Lippincott Williams & Wilkins
ISBN: 1605476331
Category: Medical
Page: 652
View: 3755

Continue Reading →

This core text offers LPN/LVN students a clear, concise introduction to pharmacology, focusing on basic principles and the nurse's responsibility in drug administration. Organized by body system, the book examines pharmacologic properties and therapeutic applications of drug classes. Summary Drug Tables present generic and trade drug names, uses, adverse reactions, and usual dosage ranges. This edition has thoroughly updated drug information, a new "Pharmacology in Practice" case study feature, Nursing Alerts, Lifespan Alerts, Chronic Care Alerts, Diversity Alerts, and additional material on the nursing process. Including a FREE copy of Lippincott’s Photo Atlas of Medication Administration, a bound CD-ROM, a companion website includes an NCLEX® alternate item format tutorial, a Spanish-English audio glossary, monographs on 100 most commonly prescribed drugs, Listen and Learn, Concepts in Action animations, Watch and Learn video clips, and Dosage Calculation Quizzes. The full text is also available online. Online Tutoring powered by Smarthinking—Free online tutoring, powered by Smarthinking, gives students access to expert nursing and allied health science educators whose mission, like yours, is to achieve success. Students can access live tutoring support, critiques of written work, and other valuable tools.

Cancer Chemotherapy

A Nursing Process Approach
Author: Margaret Barton-Burke
Publisher: Jones & Bartlett Learning
ISBN: 9780867207187
Category: Medical
Page: 727
View: 6111

Continue Reading →

This text for beginning and advanced oncology nurses integrates the nursing process, including nursing diagnosis, with the administration of cancer chemotherapeutic agents. Chapters in the first section review the history of chemotherapy and the role of the oncology nurse in chemotherapy research. The second, main part of the text presents drug information forms and nursing care plans for more than 80 drugs. Each care plan includes a table of nursing diagnoses, defining characteristics, expected outcomes, and nursing interventions related to that drug. Finally, technical procedures for administration and safe handling of anti-neoplastic agents are discussed. c. Book News Inc.

Clinical Pharmacology & Therapeutics

Proceedings of Plenary Lectures Symposia and Therapeutic Sessions of the First World Conference on Clinical Pharmacology & Therapeutics London, UK, 3–9 August 1980
Author: Paul Turner,C. Padgham,Alan Hedges
Publisher: Springer
ISBN: 1349059528
Category: Medical
Page: 576
View: 7735

Continue Reading →

Small Animal Clinical Pharmacology and Therapeutics - E-Book


Author: Dawn Merton Boothe
Publisher: Elsevier Health Sciences
ISBN: 1437723578
Category: Medical
Page: 1348
View: 3779

Continue Reading →

Confidently utilize the rapidly growing selection of pharmaceuticals used to treat small animals. Small Animal Pharmacology and Therapeutics, 2nd Edition helps you understand both the therapeutic uses of common pharmaceuticals and the pharmacology behind them, giving you all of the information you need to design and modify dosing regimens, identify factors that cause drugs to fail, and anticipate adverse drug reactions. Comprehensive approach emphasizes the use of drugs for prevention as well as treatment. Clear, consistent organization makes it easy to find the information you need when you need it. Dosage tables help you find essential pharmaceutical information at a glance. Pharmacogenetics chapter helps you understand how to use this emerging science to find the right dose for each patient, optimizing efficiency and minimizing toxicity. Routes of administration and sample pharmaceutical calculations provide fast, efficient access to comprehensive drug administration all in one inclusive resource. Multiple chapters on Antimicrobial Drugs and Antimicrobial Therapy highlight the impact of antimicrobial resistance on current practice.

Trounce's Clinical Pharmacology for Nurses E-Book


Author: Clive P. Page,Ben Greenstein,Dinah Gould
Publisher: Elsevier Health Sciences
ISBN: 0702039500
Category: Medical
Page: 512
View: 1908

Continue Reading →

With the important part played by nurses in the administration of drugs and in recording their effects, an understanding of pharmacology and its application to patient care is an integral part of pre-registration nursing education. This popular textbook gives an up-to-date account of the action and use of drugs in the treatment and prevention of disease, as well as exploring the principles underlying drug usage. The eighteenth edition of this highly successful textbook builds on the foundation of its predecessors by bringing the text fully up to date with developments in the world of clinical pharmacology and current trends in clinical practice.

Concise Clinical Pharmacology


Author: Ben Greenstein,Adam Greenstein
Publisher: Pharmaceutical Press
ISBN: 9780853695769
Category: Medical
Page: 302
View: 2279

Continue Reading →

Concise Clinical Pharmacology is a thorough introduction to the subject from which students can gain a rapid understanding of individual topics within the discipline. Pharmacological principles and mechanisms are covered, with a focus on the therapeutic use of the drugs. Concise Clinical Pharmacology will be invaluable to undergraduate pharmacy students, and clinical medical students. the strong clinical focus should also appeal to practitioners.

The Science of Cancer Treatment


Author: B.A. Ponder,M.J. Waring
Publisher: Springer Science & Business Media
ISBN: 9400907095
Category: Medical
Page: 224
View: 961

Continue Reading →

Many of the most effective treatments for disease have been discovered empir ically. Nowadays, however, we think that understanding the biology of a disease will lead us to design better treatments, and to improve the application of treatments we already have. To accomplish this, vast sums are expended on cancer research. Even so, to the casual observer of clinical oncology the proliferation of studies and trials of ever-different combinations of therapies looks like empiricism, at the best. In the first part of this book, we have asked practising clinicians in different specialities to assess the contributions of biology and of empiricism to current approaches to treatment. In the second part, we have asked researchers in different areas of biology applied to cancer to assess the present and likely future impact of their type of biology on cancer treatment and control. IX 1 Surgery M.BAUM OBJECTIVES OF CANCER TREATMENT The objectives of cancer treatment can be defined according to population requirements or according to the needs of the individual. As far as the population is concerned, Government authorities are entitled to expect that cancer treatment will lead to mortality reductions and cost containment.

Phase I Cancer Clinical Trials

A Practical Guide
Author: Elizabeth A. Eisenhauer,Christopher Twelves,Marc Buyse
Publisher: Oxford University Press
ISBN: 0199359024
Category: Medical
Page: 352
View: 9680

Continue Reading →

Phase I trials are a critical first step in the study of novel cancer therapeutic approaches. Their primary goals are to identify the recommended dose, schedule and pharmacologic behavior of new agents or new combinations of agents and to describe the adverse effects of treatment. In cancer therapeutics, such studies have particular challenges. Due to the nature of the effects of treatment, most such studies are conducted in patients with advanced malignancy, rather than in healthy volunteers. Further, the endpoints of these trials are usually measures adverse effects rather than molecular target or anti-tumor effects. These factors render the design, conduct, analysis and ethical aspects of phase I cancer trials unique. As the only comprehensive book on this topic, Phase I Cancer Clinical Trials is a useful resource for oncology trainees or specialists interested in understanding cancer drug development. New to this edition are chapters on Phase 0 Trials and Immunotherapeutics, and updated information on the process, pitfalls, and logistics of Phase I Trials

CRC Desk Reference of Clinical Pharmacology


Author: Manuchair Ebadi
Publisher: CRC Press
ISBN: 9780849396830
Category: Medical
Page: 704
View: 2147

Continue Reading →

Designed specifically with physicians, pharmacologists, and other members of the health care delivery team in mind, the CRC Desk Reference of Clinical Pharmacology features more than 2,000 entries appearing in three formats: Short reviews: these present important topics of clinical pharmacology, such as pharmacokinetic basis of therapeutics, pharmacodynamic principles, and drug-drug interactions. Major areas of therapeutics including antiemetic drugs, antihistaminics, calcium-channel blocking agents, and nonsteroidal anti-inflammatory agents are reviewed. Abstract length entries: provide short descriptions of all medications in use today Short dictionary style entries: concise, one sentence descriptions of the exact therapeutic use of each medication. Each entry gives:

Handbook of Cannabis


Author: Roger Pertwee
Publisher: OUP Oxford
ISBN: 0191639702
Category: Medical
Page: 632
View: 2886

Continue Reading →

Truly global in scope and with contributions from leading researchers around the world, The Handbook of Cannabis is the definitive resource on this fascinating drug. Combining scientific perspectives and clinical applications, it covers a vast array of topics, from why over the centuries cannabis has been used as a medicine, through the regulations facing those wishing to self-administer cannabis or provide cannabis-based medicines, to the chemical structure of its many constituents and the rapidly growing group of synthetic cannabinoids that are currently being used for 'legal highs'. With each chapter written by a group of one or more internationally recognised subject experts, it provides academics and researchers with authoritative scientific material on the main pharmacological actions and their effects, as well as their pharmacokinetics, metabolism, and forensic detection. In addition it also examines the complex morphology, cultivation, harvesting, and processing of cannabis and the ways in which the plant's chemical composition can be controlled. As well as offering a raft of scientific information there is extensive coverage of cannabinoid-based medicines. Helping readers to identify and evaluate their benefits, chapters explore pharmacological actions and the effects that seem to underlie approved therapeutic uses, how they are currently used to treat certain disorders, and the ever-growing number of wide-ranging potential clinical applications. There is also coverage of both the legal and illegal sources of cannabis, including 'coffee shops' and 'cannabis dispensaries'. The complex issue of 'recreational cannabis' is also tackled. The sought-after and adverse psychological and non-psychological effects are described and discussions are included on how some adverse effects can be lessened by at least one constituent of cannabis, and that it might be possible to reduce the harm that cannabis does to some by changing current regulatory policies. The Handbook of Cannabis is a one-stop reference; essential reading for all clinicians, pharmacologists, psychologists, and psychiatrists interested in this drug, as well as those working in the field of public health.

Clinical Pain Management Second Edition: Cancer Pain


Author: Nigel Sykes,Michael Bennet,Chun-su Yuan
Publisher: CRC Press
ISBN: 1444109804
Category: Health & Fitness
Page: 464
View: 9038

Continue Reading →

Now divided into four parts, the second edition of Cancer Pain delivers broad coverage of the issues that arise in the management of malignancy-related pain, from basic science, through end of life care and associated ethical issues, to therapies, both medical and complementary. Part One reviews basis considerations in cancer pain management, including epidemiology, pharmacology, history-taking and patient evaluation and teamworking. Part Two brings together the drug therapies for cancer pain, their underlying basis, and potential side-effects. Part Three covers the non-drug therapies, including nerve blocks, stimulation-induced analgesia, radiotherapy, complementary therapies and psychological interventions. The control of symptoms other than pain, so critical to cancer patients, is also considered here. Part Four describes special situations. Cancer pain management in children and older patients, and in the community setting, and pain in the dying patient and the cancer survivor are all covered here.

Complementary and Integrative Medicine in Cancer Care and Prevention

Foundations and Evidence-Based Interventions
Author: Marc S. Micozzi, MD. PhD
Publisher: Springer Publishing Company
ISBN: 9780826103086
Category: Medical
Page: 504
View: 3640

Continue Reading →

Provide whole care to your cancer patients with: Up-to-date information on the uses of diet, nutrition, and herbs Elucidations of the use of mind-body therapies such as Guided Imagery, Expressive Therapies, and spirituality Legal and medical guidance for incorporating Naturopathy, Acupuncture, Homeopathy, and Ayurvedic Medicine in cancer care According to the U.S. National Center for Health Statistics and the U.S. Centers for Disease Control (2004), up to 80% of cancer patients undergoing treatment by oncologists and radiation therapists also supplement their treatments with complementary and integrative medicines (CIM). Dr. Marc S. Micozzi has designed this text to provide a comprehensive resource for students and practitioners on the evidence for and applications of complementary, alternative, and integrative medical therapies. This is the first integrative oncology text for health professionals, and as such, it is essential reading for the incorporation of evidence-based practice into the care of patients with cancer and toward the prevention of cancer in the general population.

Organ Directed Toxicities of Anticancer Drugs

Proceedings of the First International Symposium on the Organ Directed Toxicities of the Anticancer Drugs Burlington, Vermont, USA-June 4–6, 1987
Author: Miles P. Hacker,John S. Lazo,Thomas R. Tritton
Publisher: Springer Science & Business Media
ISBN: 1461320232
Category: Medical
Page: 254
View: 4593

Continue Reading →

The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability to dif ferentiate between normal and neoplastic cells, little selectivity exists in currently used oncolytic drugs. Consequently, significant toxicity to the patient is expected when systemic cancer chemotherapy is chosen as an appropriate therapeutic in tervention. Much of this toxicity, such as damage to the bone marrow, gastroin testinal tract, or hair follicles, is predictable based upon the fact that anticancer drugs kill actively dividing cells. These types of toxicities, while serious, are usually manageable and reversible and are, therefore, not often considered to be dose limiting. Unfortunately, several of the most important anticancer drugs also damage tissues in which the growth fraction is relatively small. Such toxicities can not be predicted based on the chemical structure of the drugs, are often not detected in preclinical studies, and are encountered frequently for the first time in clinical studies. Further, unlike most of the proliferative-dependent toxicities, the unpre dicted toxicities are usually irreversible or only partially reversible upon cessation of drug administration. Because of this, the unpredicted toxicities are referred to as dose limiting. They represent a significant barrier to the ultimate efficacy of several of our most important anticancer drugs.

Therapeutic Drugs


Author: Colin T. Dollery
Publisher: N.A
ISBN: N.A
Category: Chemotherapy
Page: 1379
View: 2858

Continue Reading →

Organized alphabetically by generic drug name. Each entry includes the chemistry, pharmacology, toxicology, clinical pharmacology, pharmacokinetics, concentration-effect relationship, metabolism, pharmaceutics, therapeutic use, adverse reactions, high risk groups, drug interactions, and clinical trials of the drug. Bibliographical references on which the information is based are also included.